ARTÍCULO

In Vitro release from reverse poloxamine/a-cyclodextrin matrices: modelling and comparison of dissolution profiles

Autores: Larrañeta Landa, Eneko; Martínez Oharriz, María Cristina; Vélaz Rivas, María Icíar; Zornoza Cebeiro, Amaya; Machín Ledesma, Rubén; Isasi Allica, José Ramón
Título de la revista: JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN: 0022-3549
Volumen: 103
Número: 1
Páginas: 197 - 206
Fecha de publicación: 2014
Resumen:
Gels obtained by complexation of octablock star polyethylene oxide/polypropylene oxide copolymers ( Tetronic 90 R4) with alpha-cyclodextrin (alpha- CD) were evaluated as matrices for drug release. Both molecules are biocompatible so they can be potentially applied to drug delivery systems. Two different types of matrices of Tetronic 90 R4 and alpha-CD were evaluated: gels and tablets. These gels are capable to gelifying in situ and show sustained erosion kinetics in aqueous media. Tablets were prepared by freeze-drying and comprising the gels. Using these two different matrices, the release of two model molecules, L-tryptophan ( Trp), and a protein, bovine serum albumin ( BSA), was evaluated. The release profiles of these molecules from gels and tablets prove that they are suitable for sustained delivery. Mathematical models were applied to the release curves from tablets to elucidate the drug delivery mechanism. Good correlations were found for the fittings of the release curves to different equations. The results point that the release of Trp from different tablets is always governed by Fickian diffusion, whereas the release of BSA is governed by a combination of diffusion and tablet erosion.