Angiogenic therapy for cardiac repair based on protein delivery systems

Autores: Rocha Formiga, Fabio; Tamayo Revuelta, Esther; Simón Yarza, María Teresa; Pelacho Samper, Beatriz; Prósper Cardoso, Felipe Luis; Blanco Prieto, María José
Título de la revista: HEART FAILURE REVIEWS
ISSN: 1382-4147
Volumen: 17
Número: 3
Páginas: 449 - 473
Fecha de publicación: 2012
Cardiovascular diseases remain the first cause of morbidity and mortality in the developed countries and are a major problem not only in the western nations but also in developing countries. Current standard approaches for treating patients with ischemic heart disease include angioplasty or bypass surgery. However, a large number of patients cannot be treated using these procedures. Novel curative approaches under investigation include gene, cell, and protein therapy. This review focuses on potential growth factors for cardiac repair. The role of these growth factors in the angiogenic process and the therapeutic implications are reviewed. Issues including aspects of growth factor delivery are presented in relation to protein stability, dosage, routes, and safety matters. Finally, different approaches for controlled growth factor delivery are discussed as novel protein delivery platforms for cardiac regeneration.