ARTÍCULO

Screening of polyphenolic plant extracts for anti-obesity properties in Wistar rats

Autores: Boqué Terré, Noemi; Campión Zabalza, Francisco Javier; de la Iglesia González, Rocío; de la Garza Hernández, Ana Laura Isabel; Milagro Yoldi, Fermín Ignacio; San-Román, B.; Bañuelos, O.; Martínez Hernández, Alfredo
Título de la revista: JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
ISSN: 0022-5142
Volumen: 93
Número: 5
Páginas: 1226 - 1232
Fecha de publicación: 2013
Resumen:
Background Polyphenols have been reported to prevent chronic diseases such as cardiovascular diseases, cancers, diabetes and neurodegenerative diseases. The objective of the study was to conduct a screening for potential anti-obesity polyphenolic plant extracts using a diet-induced animal model. Rats were fed a high-fat-sucrose (HFS) diet with or without supplementation of different polyphenolic plant extracts (almond, apple, cinnamon, orange blossom, hamamelis, lime blossom, grape vine, and birch) for 5664 days. Results Body weight gain was lower in rats supplemented with apple, cinnamon, hamamelis and birch extracts as compared to HFS non-supplemented group. Moreover, apple and cinnamon extracts prevented the increase in fat mass promoted by the HFS diet. Insulin resistance, estimated by the homostatic model assessmentinsulin resistance (HOMA-IR) index, was reduced in rats fed apple, cinnamon, hamamelis and birch extracts. Apple extract also prevented the HFS-induced hyperglycaemia and hyperleptinaemia. Conclusion Only apple and cinnamon extracts were finally considered as potentially important anti-obesogenic extracts, due to their body fat-lowering effects, while the improvement of obesity-related metabolic complications by apple polyphenols highlights this extract as a promising functional food ingredient for the management of obesity and its metabolic complications.