ARTÍCULO

Culture of human bone marrow-derived mesenchymal stem cells on of poly(L: -lactic acid) scaffolds: potential application for the tissue engineering of cartilage

Autores: Izal, Iñigo ; Aranda, Pablo ; Sanz Ramos, Patricia ; Ripalda Cemborain, Purificación; Mora Gasque, Gonzalo; Granero Molto, Froilan; Deplaine, Harmony ; Gómez Ribelles, José Luis; Gallego Ferrer, Gloria; Acosta, Victor; Ochoa, Ignacio ; García Aznar, Jose Manuel; Andreu Oltra, Enrique José; Monleón Pradas, Manuel; Doblare, Manuel ; Prosper Cardoso, Felipe
Título de la revista: KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
ISSN: 0942-2056
Fecha de publicación: 2012
Resumen:
Biocompatible PLLA scaffolds have been developed that can be efficiently loaded with MSCs. The scaffold supports chondrogenic differentiation and ECM deposition that improves the mechanics of the scaffold. Although this improvement does not met the expectations of a hyaline-like cartilage ECM, in part due to the lack of a mechanical stimulation, their potential use in the treatment of cartilage pathologies encourages to improve the mechanical component.