Detalle Publicación

Patient experience before and after treatment with idecabtagene vicleucel (ide-cel, bb2121): qualitative analysis of patient interviews in the KarMMa trial

Autores: Shah, N. (Autor de correspondencia); Delforge, M.; San Miguel Izquierdo, Jesús; Moshkovich, O.; Braverman, J.; Dhanda, D. S.; Lanar, S.; Miera, M.; Williams, A.; Murphy, R.; Devlen, J.; Hege, K.; Campbell, T. B.; Munshi, N. C.
Título de la revista: LEUKEMIA RESEARCH
ISSN: 0145-2126
Volumen: 120
Páginas: 106921
Fecha de publicación: 2022
Objective: To understand the experience of patients with relapsed and refractory multiple myeloma (RRMM) receiving idecabtagene vicleucel (ide-cel), a B-cell maturation antigen-directed chimeric antigen receptor T cell therapy, in the pivotal, phase 2 KarMMa trial. Methods: Optional semi-structured interviews before leukapheresis (pre-treatment) captured expectations and after ide-cel infusion (1, 2, and 3 months post-treatment), assessed treatment experience, ide-cel advantages/ disadvantages, and health and well-being. In a mixed-method analysis, treatment experiences were categorized by clinical response status, health and well-being, and self-reported recovery after infusion.Results: Pre-treatment interviews indicated unmet treatment needs. In post-treatment interviews, most patients reported the positives of ide-cel outweighed negatives (69%, n = 27/39). Most common advantages of ide-cel were efficacy (18-64%), favorable side-effect profile (46-68%), and recovery time (13-18%); most common disadvantages were related to side effects (13-20%). When analyzed by clinical response, patients most often had stringent complete or very good partial response and improved health and well-being with mild or severe recovery from the infusion (27/58, 47%). Most patients with minimal clinical response reported mild infusion recovery (5/6, 83%).Conclusions: Patient interviews before ide-cel treatment showed unmet needs in triple-class exposed RRMM. Posttreatment experiences generally favored ide-cel versus previously received treatments.