Detalle Publicación

Immunomodulatory potential of non-classical HLA-G in infections including COVID-19 and parasitic diseases

Autores: Rashidi, S.; Vieira, C.; Tuteja, R.; Mansouri, R.; Ali-Hassanzadeh, M.; Muro, A.; Nguewa, Paul (Autor de correspondencia); Manzano-Román, R. (Autor de correspondencia)
Título de la revista: BIOMOLECULES
ISSN: 2218-273X
Volumen: 12
Número: 2
Páginas: 257
Fecha de publicación: 2022
Human Leukocyte Antigen-G (HLA-G), a polymorphic non-classical HLA (HLA-Ib) with immune-regulatory properties in cancers and infectious diseases, presents both membrane-bound and soluble (sHLA-G) isoforms. Polymorphism has implications in host responses to pathogen infections and in pathogenesis. Differential expression patterns of HLA-G/sHLA-G or its polymorphism seem to be related to different pathological conditions, potentially acting as a disease progression biomarker. Pathogen antigens might be involved in the regulation of both membrane-bound and sHLA-G levels and impact immune responses during co-infections. The upregulation of HLA-G in viral and bacterial infections induce tolerance to infection. Recently, sHLA-G was found useful to identify the prognosis of Coronavirus disease 2019 (COVID-19) among patients and it was observed that the high levels of sHLA-G are associated with worse prognosis. The use of pathogens, such as Plasmodium falciparum, as immune modulators for other infections could be extended for the modulation of membrane-bound HLA-G in COVID-19-infected tissues. Overall, such information might open new avenues concerning the effect of some pathogens such as parasites in decreasing the expression level of HLA-G to restrict pathogenesis in some infections or to influence the immune responses after vaccination among others.