Detalle Publicación

LocoMMotion: a prospective, non-interventional, multinational study of real-life current standards of care in patients with relapsed and/or refractory multiple myeloma

Autores: Mateos, M. V. (Autor de correspondencia); Weisel, K.; De Stefano, V.; Goldschmidt, H.; Delforge, M.; Mohty, M.; Cavo, M.; Vij, R.; Lindsey-Hill, J.; Dytfeld, D.; Angelucci, E.; Perrot, A.; Benjamin, R.; van de Donk, N. W. C. J.; Ocio, E. M.; Scheid, C.; Gay, F.; Roeloffzen, W.; Rodríguez Otero, Paula; Broijl, A.; Potamianou, A.; Sakabedoyan, C.; Semerjian, M.; Keim, S.; Strulev, V.; Schecter, J. M.; Vogel, M.; Wapenaar, R.; Nesheiwat, T.; San Miguel Izquierdo, Jesús; Sonneveld, P.; Einsele, H.; Moreau, P.
Título de la revista: LEUKEMIA
ISSN: 0887-6924
Volumen: 36
Número: 5
Páginas: 1371 - 1376
Fecha de publicación: 2022
Despite treatment advances, patients with multiple myeloma (MM) often progress through standard drug classes including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and anti-CD38 monoclonal antibodies (mAbs). LocoMMotion ( identifier: NCT04035226) is the first prospective study of real-life standard of care (SOC) in triple-class exposed (received at least a PI, IMiD, and anti-CD38 mAb) patients with relapsed/refractory MM (RRMM). Patients (N = 248; ECOG performance status of 0-1, >= 3 prior lines of therapy or double refractory to a PI and IMiD) were treated with median 4.0 (range, 1-20) cycles of SOC therapy. Overall response rate was 29.8% (95% CI: 24.2-36.0). Median progression-free survival (PFS) and median overall survival (OS) were 4.6 (95% CI: 3.9-5.6) and 12.4 months (95% CI: 10.3-NE). Treatment-emergent adverse events (TEAEs) were reported in 83.5% of patients (52.8% grade 3/4). Altogether, 107 deaths occurred, due to progressive disease (n = 74), TEAEs (n = 19), and other reasons (n = 14). The 92 varied regimens utilized demonstrate a lack of clear SOC for heavily pretreated, triple-class exposed patients with RRMM in real-world practice and result in poor outcomes. This supports a need for new treatments with novel mechanisms of action.