Detalle Publicación

Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

Autores: Paslakis, G.; Aguera, Z. ; Granero, R.; Sanchez, I. ; Riesco, N.; Jimenez-Murcia, S. ; Fernandez-Garcia, J. C.; Garrido-Sanchez, L.; Tinahones, F. J.; Casanueva, F. F.; Banos, R. M.; Botella, C.; Crujeiras, A. B.; de la Torre, R.; Fernandez-Real, J. M.; Fruhbeck Martínez, Gema; Ortega, F. J.; Rodríguez Murueta-Goyena, Amaia; Serra-Majem, L.; Fito, M. ; Menchon, J. M. ; Fernandez-Aranda, F. (Autor de correspondencia)
ISSN: 0303-7207
Volumen: 497
Fecha de publicación: 2019
Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.