ARTÍCULO

Perfil farmacológico del isavuconazol

Autores: Azanza Perea, José Ramón (Autor de correspondencia); Sadaba Díaz de Rada, María Belén
Título de la revista: REVISTA IBEROAMERICANA DE MICOLOGIA
ISSN: 1130-1406
Volumen: 35
Número: 4
Páginas: 186 - 191
Fecha de publicación: 2018
Lugar: WOS
Resumen:
Isavuconazole is a new azole, structurally related to fluconazole and voriconazole, that presents a very high oral absorption with no first-pass effect which is not interfered by the presence of food, gastric pH modifications, or mucositis. Its distribution volume is very high, probably also to cerebrospinal fluid, in spite of the fact that it circulates highly bound to plasma proteins. It is extensively metabolized through the CYP3A4 isoenzyme. Due to this reason, it is recommended to avoid co-administration with strong CYP3A4 inducers. In addition, isavuconazole may inhibit CYP3A4. Moreover, it may induce CYP2B6 and Pglycoprotein. Interestingly, this inhibitory activity seems to be lower compared to other azoles. Therefore, the management of any interaction with other medicines is easier, which is probably the most important advantage of this antifungal. (C) 2018 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.