ARTÍCULO

Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

Autores: Cantero González, Irene; Abete Goñi, Itziar; Babio, N.; Aros, F. ; Corella, D.; Estruch, R.; Fito, M. ; Hebert, J. R.; Martínez González, Miguel Ángel; Pinto, X. ; Portillo, M. P.; Ruiz-Canela, Miguel; Shivappa, N.; Warnberg, J.; Gomez-Gracia, E.; Tur, J. A.; Salas-Salvado, J. ; Zulet Alzórriz, María de los Ángeles (Autor de correspondencia); Martínez Hernández, Alfredo
Título de la revista: CLINICAL NUTRITION
ISSN: 0261-5614
Volumen: 37
Número: 5
Páginas: 1736 - 1743
Fecha de publicación: 2018
Lugar: WOS
Resumen:
Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean +/- SD age: 67.0 +/- 5.0 y, 55% females) from the PREDIMED (PREvencion con Dleta MEDiterranea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.