ARTÍCULO

Nanomedicines for Pediatric Cancers

Autores: Rodríguez Nogales, Carlos; González Fernández, Yolanda; Aldaz Pastor, Azucena; Couvreur, P.; Blanco Prieto, María José (Autor de correspondencia)
Título de la revista: ACS NANO
ISSN: 1936-0851
Volumen: 12
Número: 8
Páginas: 7482 - 7496
Fecha de publicación: 2018
Lugar: WOS
Resumen:
Chemotherapy protocols for childhood cancers are still problematic due to the high toxicity associated with chemotherapeutic agents and incorrect dosing regimens extrapolated from adults. Nanotechnology has demonstrated significant ability to reduce toxicity of anticancer compounds. Improvement in the therapeutic index of cytostatic drugs makes this strategy an alternative to common chemotherapy in adults. However, the lack of nanomedicines specifically for pediatric cancer care raises a medical conundrum. This review highlights the current state and progress of nanomedicine in pediatric cancer and discusses the real clinical challenges and opportunities.