ARTÍCULO

Liquid biopsy: from basic research to clinical practice

Autores: Macías Conde, Mónica; Alegre Martínez, Estíbaliz; Díaz Lagares, Ángel; Patiño García, Ana; Pérez Gracia, José Luis; Fernández de Sanmamed Gutiérrez, Miguel; Lopez-Lopez, R. ; Varo Cenarruzabeitia, Miren Nerea; González Hernández, Álvaro (Autor de correspondencia)
Título de la revista: ADVANCES IN CLINICAL CHEMISTRY
ISSN: 0065-2423
Volumen: 83
Páginas: 73 - 119
Fecha de publicación: 2018
Lugar: WOS
Resumen:
Liquid biopsy refers to the molecular analysis in biological fluids of nucleic acids, subcellular structures, especially exosomes, and, in the context of cancer, circulating tumor cells. In the last 10 years, there has been an intensive research in liquid biopsy to achieve a less invasive and more precise personalized medicine. Molecular assessment of these circulating biomarkers can complement or even surrogate tissue biopsy. Because of this research, liquid biopsy has been introduced in clinical practice, especially in oncology, prenatal screening, and transplantation. Here we review the biology, methodological approaches, and clinical applications of the main biomarkers involved in liquid biopsy.