Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Autores: Vázquez Urio, Iria; Maicas Irigarai, Miren; Cervera, J.; Aguirre Ena, Xabier; Marcotegui Arza, Nerea; Vicente Vázquez, Carmen; Valencia, A.; Brunet, S.; Lumbreras, E.; Prósper Cardoso, Felipe Luis; Gómez-Casares, M. T.; Hernández-Rivas, J. M.; Calasanz Abinzano, María José; Sanz, M. A.; Sierra, J.; Odero de Dios, María Dolores
ISSN: 0390-6078
Volumen: 96
Número: 10
Páginas: 1448 - 1456
Fecha de publicación: 2011
Our results identify EVI1 over-expression as a poor prognostic marker in a large, independent cohort of acute myeloid leukemia patients less than 65 years old, and show that the total absence of EVI1 expression has a prognostic impact on the outcome of such patients. Furthermore, we demonstrated for the first time that an aberrant epigenetic pattern involving DNA methylation, H3 and H4 acetylation, and trimethylation of histone H3 lysine 4 and histone H3 lysine 27 might play a role in the transcriptional regulation of EVI1 in acute myeloid leukemia. This study opens new avenues for a better understanding of the regulation of EVI1 expression at a transcriptional level.