Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report

Autores: Pujol Giménez, Jonai; Pérez de Heredia, F.; Idoate Gastearena, Miguel Ángel; Airley, R.; Lostao Crespo, María del Pilar; Evans, A. R.
Título de la revista: JOURNAL OF CANCER
ISSN: 1837-9664
Volumen: 6
Número: 2
Páginas: 139 - 143
Fecha de publicación: 2015
Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment