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Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro anti Trypanosoma cruzi activity

Autores: Pérez Silanes, Silvia; Torres Eguia, Eduardo; Arbillaga Lacunza, Leire; Varela, J.; Cerecetto, H.; González, M.; Azqueta Oscoz, Amaya; Moreno de Viguri, Elsa
Título de la revista: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
ISSN: 0960-894X
Volumen: 26
Número: 3
Páginas: 903 - 906
Fecha de publicación: 2016
Resumen:
We report the synthesis and in vitro activity against Trypanosoma cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 values lower than 1.5 ¿M. Moreover, unspecific cytotoxicity and genotoxicity studies are also reported. Compound 14 showed a SI higher than 24, whereas compound 10 was the only one that was negative in the genotoxicity screening.
DOI: https://doi.org/10.1016/j.bmcl.2015.12.070
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