ARTÍCULO

Reformulating cyclosporine A (CsA): more than just a life cycle management strategy

Autores: Guada Ramírez, Melissa; Beloqui, A.; Kumar, M. N. ; Préat, V.; Dios Viéitez, María del Carmen; Blanco Prieto, María José
Título de la revista: JOURNAL OF CONTROLLED RELEASE
ISSN: 0168-3659
Volumen: 225
Páginas: 269 - 282
Fecha de publicación: 2016
Resumen:
Cyclosporine A (CsA) is a well-known immunosuppressive agent that gained considerable importance in transplant medicine in the late 1970s due to its selective and reversible inhibition of T-lymphocytes. While CsA has been widely used to prevent graft rejection in patients undergoing organ transplant it was also used to treat several systemic and local autoimmune disorders. Currently, the neuro-and cardio-protective effects of CsA (CiCloMulsion (R); NeuroSTAT (R)) are being tested in phase II and III trials respectively and NeuroSTAT (R) received orphan drug status from US FDA and Europe in 2010. The reformulation strategies focused on developing Cremophor (R) EL free formulations and address variable bioavailability and toxicity issues of CsA. This reviewis an attempt to highlight the progressmade so far and the roomavailable for further improvements to realize the maximum benefits of CsA.