ARTÍCULO

Anchoring interferon alpha to apolipoprotein A-I reduces hematological toxicity while enhancing immunostimulatory properties.

Autores: Fioravanti, Jessica; González de la Tajada, Iranzu; Medina Echeverz, José; Larrea Leoz, María Esther; Ardaiz Iriarte, Nuria María; González Aseguinolaza, Gloria; Prieto Valtueña, Jesús María; Berraondo López, Pedro
Título de la revista: Hepatology
ISSN: 0270-9139
Volumen: 53
Número: 6
Páginas: 1864 - 1873
Fecha de publicación: 2011
Resumen:
Interferon alpha (IFN alpha) is widely used for the treatment of viral hepatitis but substantial toxicity hampers its clinical use. In this work, we aimed at improving the efficacy of IFN alpha therapy by increasing the IFN alpha half-life and providing l