ARTÍCULO

Precision obesity treatments including pharmacogenetic and nutrigenetic approaches

Autores: Solas Zubiaurre, Maite; Milagro Yoldi, Fermín Ignacio; Martínez Urbistondo, Diego; Ramírez Gil, María Javier; Martínez Hernández, Alfredo
Título de la revista: TRENDS IN PHARMACOLOGICAL SCIENCES
ISSN: 0165-6147
Volumen: 37
Número: 7
Páginas: 575-593
Fecha de publicación: 2016
Resumen:
Five pharmaceutical strategies are currently approved by the US FDA for the treatment of obesity: orlistat, lorcaserin, liraglutide, phentermine/topiramate, and bupropion/naltrexone. The most effective treatment seems to be the combined administration of phentermine/topiramate followed by lorcaserin and bupropion/naltrexone. In relation to the management of excessive weight, other aspects also need to be considered, including comorbidities accompanying obesity, drug interactions, and the risk of negative collateral effects, as well as individualized treatments based on the genetic make-up. This review aims to provide an overview of the approved anti-obesity drugs and newer molecules that could affect different targets in the central nervous system or peripheral tissues, the molecular mechanisms, emerging dietary treatments and phytogenic compounds, and pharmacogenetic/nutrigenetic approaches for personalized obesity management.