ARTÍCULO

Some basic aspects of HLA-G biology

Autores: Alegre Martínez, Estíbaliz; Rizzo, R.; Bortolotti, D.; Fernández Landázuri, Sara; Fainardi, E.; González Hernández, Álvaro
Título de la revista: JOURNAL OF IMMUNOLOGY RESEARCH
ISSN: 2314-8861
Volumen: 2014
Páginas: 657625
Fecha de publicación: 2014
Resumen:
Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.