Revistas
Revista:
JOURNAL OF POLYMERS AND THE ENVIRONMENT
ISSN:
1566-2543
Año:
2022
Vol.:
30
Págs.:
1189 - 1198
A cyclodextrin-based polymer was prepared by crosslinking beta-cyclodextrin with epichlorohydrin to be assessed as a sorbent material for cresols in packed-bed columns. Both Langmuir and Freundlich isotherms were appropriate to describe the sorption equilibrium in the conditions tested, and the thermodynamic parameters obtained for this process confirmed its exothermic nature with similar enthalpies (between - 6.8 and - 8.3 kJ/mol) for the three isomers. The removal of cresols from water was carried out in nine cycles of sorption-desorption in fixed-column experiments with the cyclodextrin hydrogel, achieving sorption capacities of 6.2, 11.6, and 15.1 mg/g for o-, m-, p-cresol, respectively. These differences in sorption capacities are due to the different chemical structures of cresols, that is, the relative position of the methyl and hydroxyl groups. However, similar sorption rates were observed for each isomer, with a mean value of 0.10 mg-cresol g-CDP-1 min(-1) in all cases. The experimental data for the breakthrough and the elution curves have been successfully modeled by two effective two-parameter equations, a dose-response model for the sorption step and a pulse-peak model for the regeneration step. The cyclodextrin polymer matrix has been proven to be an effective a good sorbent material for removing cresols from water, exhibiting remarkable reusability performance and structural stability throughout the successive elution steps carried out with methanol.
Autores:
Rosés, C.; Nieto, J. A.; Viadel, B.; et al.
Revista:
FOODS
ISSN:
2304-8158
Año:
2021
Vol.:
10
N°:
12
Págs.:
3020
The gut microbiota plays a key role in gastrointestinal immune and metabolic functions and is influenced by dietary composition. An in vitro protocol simulating the physiological conditions of the digestive system helps to study the effects of foods/biocompounds on gut microbiome and metabolome. The Dynamic-Colonic Gastrointestinal Digester consists of five interconnected compartments, double jacket vessels that simulate the physiological conditions of the stomach, the small intestine and the three colonic sections, which are the ascending colon, transverse colon and descending colon. Human faeces are required to reproduce the conditions and culture medium of the human colon, allowing the growth of the intestinal microbiota. After a stabilization period of 12 days, a food/biocompound can be introduced to study its modulatory effects during the next 14 days (treatment period). At the end of the stabilization and treatment period, samples taken from the colon compartments are analysed. The 16S rRNA gene analysis reveals the microbiota composition. The untargeted metabolomics analysis gives more than 10,000 features (metabolites/compounds). The present protocol allows in vitro testing of the modulatory effects of foods or biocompounds on gut microbiota composition and metabolic activity.
Revista:
EUROPEAN JOURNAL OF NUTRITION
ISSN:
1436-6207
Purpose Obesity has been related to intestinal dysbiosis and the modification of gut microbiota composition by dietary strategies becomes a promising strategy to help manage obesity. The aim of the current study was to evaluate the effect of two weight-loss diets on the composition and functional profile of gut microbiota. Methods 55 men and 124 women with BMI > 25 kg/m(2) were randomly assigned to moderately high-protein (MHP) or low-fat (LF) diet. Differences in fecal bacteria abundance (based on 16 s rRNA sequencing) between before and after 4 months of calorie restriction was analyzed using EdgeR tool in MicrobiomeAnalyst platform. Bacterial functional profile was predicted using Tax4Fun and metagenomeSeq analysis. Significant KEGG Orthology (KO) terms were selected for the metabolomic study using chromatography. Results After the intervention, MHP-men showed a significant decrease in Negativicutes, Selenomonadales, Dielma and Dielma fastidiosa. LF-men showed a significant increase in Bacilli, Lactobacillales, Christensenellaceae, Peptococcaceae, and Streptococcaceae, Peptococcus, Streptococcus and Christensenella, Duncaniella dubosii_CP039396_93.49%, Roseburia sp_AB744234_98.96% and Alistipes inops_KJ572413_99.57%. MHP-women increased Pasteurellales, Phascolarctobacterium succinatutens, Ruthenibacterium lactatiformans_LR215981_99.55% and decreased in Phascolarctobacterium succinatutens_NR112902_99.56%. Finally, LF-women presented a significant decrease in Bacteroides clarus and Erysipelothrix inopinata_CP060715_84.4%. Surprisingly, no matching bacterial changes were found between these four groups. A total of 42 KO, 10 metabolic pathways and 107 related metabolites related were found implicated in these bacterial changes. Seven metabolites were confirmed in plasma. Conclusion Weight-loss-related-changes in gut microbiome composition and the functional profile occur in a sex- and diet-related manner, showing that women and men could differentially benefit from the consumption of MHP and LF diets.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Año:
2020
Vol.:
11
N°:
5
Págs.:
4512 - 4524
The metabolic properties of omega-6 fatty acid consumption are being increasingly accepted. We had previously observed that supplementation with a borage seed oil (BSO), as a source of linoleic (18:2n-6; LA) and gamma-linolenic (18:3n-6; GLA) acids, reduces body weight and visceral adiposity and improves insulin sensitivity in a diet-induced obesity model of Wistar rats. Here, it was investigated whether the anti-obesogenic properties of BSO could be maintained in a pre-obese model of rats, and if these effects are enhanced by a combination with low doses of quercetin, together with its potential role in the regulation of the adipocyte biology. The combination of BSO and quercetin during 8 weeks was able to ameliorate glucose intolerance and insulin resistance, and to improve liver steatosis. Although no effects were observed on body weight, animals supplemented with this combination exhibited a lower proportion of visceral adiposity. In addition, in vitro differentiation of epididymal adipose-precursor cells of the BSO-treated animals exhibited a down-regulation of Fasn, Glut4, Pparg and Srebp1 genes, in comparison with the control group. Finally, in vitro evaluation of the components of BSO demonstrated that the anti-adipogenic activity of quercetin was significantly potentiated by the combination with both LA and GLA through the down-regulation of different adipogenesis-key genes in 3T3-L1 cells. All these data suggest that omega-6 fatty acids LA and GLA, and their natural sources such as BSO, could be combined with quercetin to potentiate their effects in the prevention of the excess of adiposity and the insulin resistance.
Revista:
PHARMACEUTICALS
ISSN:
1424-8247
Año:
2020
Vol.:
13
N°:
11
Págs.:
355
Supplementation with bioactive compounds capable of regulating energy homeostasis is a promising strategy to manage obesity. Here, we have screened the ability of different phenolic compounds (myricetin, kaempferol, naringin, hesperidin, apigenin, luteolin, resveratrol, curcumin and epicatechin), and phenolic acids (p-coumaric, ellagic, ferulic, gallic and vanillic acids) regulating C. elegans fat accumulation. Resveratrol exhibited the strongest lipid-reducing activity, which was accompanied by the improvement of lifespan, oxidative stress and ageing, without affecting worm development. Whole-genome expression microarrays demonstrated that resveratrol affected fat mobilization, fatty acid metabolism, and unfolded protein response of the endoplasmic reticulum (UPRER), mimicking the response to calorie restriction. Apigenin induced the oxidative stress response and lipid mobilization, while vanillic acid affected the unfolded-protein response in ER. In summary, our data demonstrates that phenolic compounds exert a lipid-reducing activity in C. elegans through different biological processes and signaling pathways, including those related with lipid mobilization and fatty acid metabolism, oxidative stress, ageing and UPR-ER response. These findings open the door to the possibility of combining them in order to achieve complementary activity against obesity-related disorders.
Revista:
JOURNAL OF FUNCTIONAL FOODS
ISSN:
1756-4646
Año:
2019
Vol.:
59
Págs.:
319 - 328
Brassicaceae contain bioactive compounds with potential positive effects on metabolic syndrome. Here, we evaluated the eventual anti-obesity properties of an ethanolic broccoli extract (BE), selected by a tested ability to reduce Caenorhabditis elegans fat content. Two doses (14 and 140 mg/kg animal) of BE were evaluated in a diet-induced obesity (DIO) Wistar rat model.
After 10 weeks of BE supplementation, animals exhibited reduced body weight gain and food efficiency, decreased atherogenic index of plasma and improved glucose tolerance in comparison with non-supplemented rats. BE also reduced the retroperitoneal fat mass and adipocyte size, all associated to down-regulation of Cebpa, Srebp1, Fasn and Adipoq expression in adipocytes. Finally, BE significantly decreased liver steatosis, accompanied by the up-regulation of Acot8 and Acox1, and the down-regulation of Fasn, Fatp4 and Srebf1 expression in hepatocytes. Our data provides new knowledge about the potential role of broccoli components in the prevention of metabolic syndrome.
Revista:
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
ISSN:
1226-086X
Año:
2019
Vol.:
75
Págs.:
93 - 99
This paper examines the long-term application of a cyclodextrin hydrogel sorbent in multiple sorption-desorption cycles. Aqueous phenol was the target pollutant, whilst methanol, ethanol and isopropanol were chosen as eluents. The experimental results were well described by empirical models: the breakthrough curves by a two-parameter dose-response equation, and the elution curves by a pulse peak equation with two independent parameters. The differences in polarity of solvents produced sorbent fragmentation, particularly marked for isopropanol and considerably lower for methanol, and therefore a progressive increase in mass-transfer coefficients. In addition, a dual approach was developed from the proposed breakthrough model to address the mass transport of sorbate within the packed beds. The first one defines an average mass-transfer coefficient as representative for each complete sorption cycle, whereas a time-profile of this coefficient is deduced in the second method. A sorption capacity of 29.6 mg-phenol/g-sorbent was found in the working conditions.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Año:
2019
Vol.:
10
N°:
8
Págs.:
4811 - 4822
Cocoa polyphenols exhibit high antioxidant activity and have been proposed as a potential adjuvant for the treatment of metabolic disturbances. Here, we demonstrate that supplementation with low doses (14 and 140 mg per kg per rat) of a complete cocoa extract induces metabolic benefits in a diet-induced obesity (DIO) model of Wistar rats. After 10 weeks, cocoa extract-supplemented animals exhibited significantly lower body weight gain and food efficiency, with no differences in energy intake. Cocoa significantly reduced visceral (epididymal and retroperitoneal) and subcutaneous fat accumulation accompanied by a significant reduction in the adipocyte size, which was mediated by downregulation of the adipocyte-specific genes Cebpa, Fasn and Adipoq. Additionally, cocoa extract supplementation reduced the triacylglycerol/high density lipoprotein (TAG/HDL) ratio, decreased hepatic triglyceride accumulation, improved insulin sensitivity by reducing HOMA-IR, and significantly ameliorated glucose tolerance after an intraperitoneal glucose tolerance test. Finally, no adverse effect was observed in an in vivo toxicity evaluation of our cocoa extract at doses up to 500 mg kg -1 day -1. Our data demonstrate that low doses of cocoa extract supplementation (14 and 140 mg kg -1 day -1) are safe and sufficient to counteract obesity and type-2 diabetes in rats and provide new insights into the potential application of cocoa supplements in the management of the metabolic syndrome.
Revista:
MOLECULES
ISSN:
1420-3049
Año:
2019
Vol.:
24
N°:
6
Págs.:
1 - 21
Phenolic compounds might modulate adiposity. Here, we report our observation that polyphenols and phenolic acids inhibit adipogenesis in 3T3-L1 with different intensity depending on the family and the stage of differentiation. While quercetin and resveratrol inhibited lipid accumulation along the whole process of differentiation, apigenin and myricetin were active during the early and latest stages, but not intermediate, contrary to hesperidin. The activity of phenolic acids was limited to the early stages of the differentiation process, except p-coumaric and ellagic acids. This anti-adipogenic effect was accompanied by down-regulation of Scd1 and Lpl. Molecular docking analysis revealed that the inhibitory activity of these phenolic compounds over the early stages of adipogenesis exhibits a significant correlation (r = 0.7034; p = 0.005) with their binding affinity to the ligand-binding domain of PPAR¿. Results show that polyphenols and phenolic acids would interact with specific residues of the receptor, which could determine their potential anti-adipogenic activity during the early stages of the differentiation. Residues Phe264, His266, Ile281, Cys285 and Met348 are the most frequently involved in these interactions, which might suggest a crucial role for these amino acids modulating the activity of the receptor. These data contribute to elucidate the possible mechanisms of phenolic compounds in the control of adipogenesis.
Autores:
Navarro-Herrera, D.; Aranaz, Paula; Eder-Azanza, L.; et al.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Año:
2018
Vol.:
9
N°:
8
Págs.:
4340 - 4351
Obesity is a medical condition with increasing prevalence, characterized by an accumulation of excess fat that could be improved using some bioactive compounds. However, many of these compounds with in vitro activity fail to respond in vivo, probably due to the sophistication of the physiological energy regulatory networks. In this context, C. elegans has emerged as a plausible model for the identification and characterization of the effect of such compounds on fat storage in a complete organism. However, the results obtained in such a simple model are not easily extrapolated to more complex organisms such as mammals, which hinders its application in the short term. Therefore, it is necessary to obtain new experimental data about the evolutionary conservation of the mechanisms of fat loss between worms and mammals. Previously, we found that some omega-6 fatty acids promote fat loss in C. elegans by up-regulation of peroxisomal fatty acid Ã-oxidation in an omega-3 independent manner. In this work, we prove that the omega-6 fatty acids¿ effects on worms are also seen when they are supplemented with a natural omega-6 source (borage seed oil, BSO). Additionally, we explore the anti-obesity effects of two doses of BSO in a diet-induced obesity rat model, validating the up-regulation of peroxisomal fatty acid Ã-oxidation. The supplementation with BSO significantly reduces body weight gain and energy efficiency and prevents white adipose tissue accumulation without affecting food
Autores:
Navarro Herrera, D.; Aranaz, Paula; Eder-Azanza, L.; et al.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Año:
2018
Vol.:
9
N°:
3
Págs.:
1621 - 1637
Bioactive compounds, including some fatty acids (FAs), can induce beneficial effects on body fat-content and metabolism. In this work, we have used C. elegans as a model to examine the effects of several FAs on body fat accumulation. Both omega-3 and omega-6 fatty acids induced a reduction of fat content in C. elegans, with linoleic, gamma-linolenic and dihomo-gamma-linolenic acids being the most effective ones. These three FAs are sequential metabolites especially in omega-6 PUFA synthesis pathway and the effects seem to be primarily due to dihomo-gamma-linolenic acid, and independent of its transformation into omega-3 or arachidonic acid. Gene expression analyses suggest that peroxisomal beta oxidation is the main mechanism involved in the observed effect. These results point out the importance of further analysis of the activity of these omega-6 FAs, due to their potential application in obesity and related diseases.
Revista:
LIPIDS IN HEALTH AND DISEASE
ISSN:
1476-511X
Año:
2018
Vol.:
17
Págs.:
103
Background: Eicosapentaenoic acid (EPA) and alpha-lipoic acid (alpha-LA) have been investigated for their beneficial effects on obesity and cardiovascular risk factors. In the current research, the goal was to evaluate metabolomic changes following the dietary supplementation of these two lipids, alone or combined in healthy overweight/obese sedentary women following an energy-restricted diet. For this purpose, an untargeted metabolomics approach was conducted on urine samples using liquid chromatography coupled with time of flight mass spectrometry (HPLC-TOF-MS). Methods: This is a short-term double blind placebo-controlled study with a parallel nutritional design that lasted 10 weeks. Participants were assigned to one of the 4 experimental groups [Control, EPA (1.3 g/d), alpha-LA (0.3 g/d) and EPA+alpha-LA (1.3 g/d + 0.3 g/d)]. All intervention groups followed an energy-restricted diet of 30% less than total energy expenditure. Clinically relevant biochemical measurements were analyzed. Urine samples (24 h) were collected at baseline and after 10 weeks. Untargeted metabolomic analysis on urine samples was carried out, and principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were performed for the pattern recognition and characteristic metabolites identification. Results: Urine samples were scattered in the PCA scores plots in response to the supplementation with alpha-LA. Totally, 28 putative discriminant metabolites in positive ionization, and 6 in negative ionization were identified among groups clearly differentiated according to the a-LA administration. Remarkably is the presence of an ascorbate intermediate metabolite (one of the isomers of trihydroxy-dioxohexanoate, or dihydroxy-oxohexanedionate) in the groups supplemented with aLA. This fact might be associated with antioxidant properties of both alpha-LA and ascorbic acid. Correlations between phenotypical parameters and putative metabolites of provided additional information on whether there is a direct or inverse relationship between them. Especially interesting are the negative correlation between ascorbate intermediate metabolite and asymmetric dimethylarginine (ADMA) and the positive one between superoxide dismutase (SOD) and aLA supplementation. Conclusions: This metabolomic approach supports that the beneficial effects of alpha-LA administration on body weight reduction may be partly explained by the antioxidant properties of this organosulfur carboxylic acid mediated by isomers of trihydroxy-dioxohexanoate, or dihydroxy-oxohexanedionate.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Obesity and type 2-diabetes are becoming a worldwide health problem, remarking the importance of alternative therapies to tackle their progression. Here, we hypothesized that supplementation of diet with 6 % w/w of a freeze-dried strawberry-blueberry (5:1) powder (FDSB) could exert beneficial metabolic effects in Wistar rats. FDSB-supplemented animals experienced significantly reduced body weight gain, food efficiency and visceral adiposity accumulation in two independent experiments. FDSB supplementation also contributed to lower area under the curve after an intraperitoneal GTT and reduced serum insulin levels and insulin resistance index (IR-HOMA) in HFS diet-fed animals, together with reduced plasma MCP-1 inflammation marker concentrations. Gene expression analysis in retroperitoneal adipocytes from experiment 1 and 3T3-L1 cells showed that FDSB inhibited adipogenesis and lipogenesis through down-regulation of Pparg, Cebpa, Lep, Fasn, Scd-1 and Lpl gene expression. Untargeted metabolomics identified the cis isomer ofresveratrol-3-glucoside-sulphate as a metabolite differentially increased in FDSB-treated serum samples, which corresponds to a strawberry metabolite that could be considered a serum biomarker of FDSB-intake. Our results suggest that FDSB powder might be useful for treatment/prevention of obesity-related diseases.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Año:
2016
Vol.:
7
N°:
4
Págs.:
1924 - 1931
Metabolomics is used to assess the compliance and bioavailability of food components, as well as to evaluate the metabolic changes associated with food consumption. This study aimed to analyze the effect of consuming ready-to-eat meals containing a cocoa extract, within an energy restricted diet on urinary metabolomic changes. Fifty middle-aged volunteers [30.6 (2.3) kg m(-2)] participated in a 4-week randomised, parallel and double-blind study. Half consumed meals supplemented with 1.4 g of cocoa extract (645 mg polyphenols) while the remaining subjects received meals without cocoa supplementation. Ready-to-eat meals were included within a 15% energy restricted diet. Urine samples (24 h) were collected at baseline and after 4 weeks and were analyzed by high-performance-liquid chromatography-time-of-flight-mass-spectrometry (HPLC-TOF-MS) in negative and positive ionization modes followed by multivariate analysis. The relationship between urinary metabolites was evaluated by the Spearman correlation test. Interestingly, the principal component analysis discriminated among the baseline group, control group at the endpoint and cocoa group at the endpoint (p < 0.01), although in the positive ionization mode the baseline and control groups were not well distinguished. Metabolites were related to theobromine metabolism (3-methylxanthine and 3-methyluric acid), food processing (L-beta-aspartyl-L-phenylalanine), flavonoids (2,5,7,3', 4'-pentahydroxyflavanone-5-O-glucoside and 7,4'-dimethoxy-6-C-methylflavanone), catecholamine (3-methoxy-4-hydroxyphenylglycol-sulphate) and endogenous metabolism (uridine monophosphate). These metabolites were present in higher (p < 0.001) amounts in the cocoa group. 3-Methylxanthine and L-beta-aspartyl-L-phenylalanine were confirmed with standards. Interestingly, 3-methoxy-4-hydroxyphenylglycol-sulphate was positively correlated with 3-methylxanthine (rho = 0.552; p < 0.001) and 7,4'-dimethoxy-6-C-methylflavanone (rho = 447; p = 0.002). In conclusion, the metabolomic approach supported the compliance of the volunteers with the intervention and suggested the bioavailability of cocoa compounds within the meals.
Revista:
FOOD & FUNCTION
ISSN:
2042-6496
Año:
2015
Vol.:
6
N°:
8
Págs.:
2758 - 2767
Faecal non-targeted metabolomics deciphers metabolic end-products resulting from the interactions among food, host genetics, and gut microbiota. Faeces from Wistar rats fed a high-fat sucrose (HFS) diet supplemented with trans-resveratrol and quercetin (separately or combined) were analysed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS). Metabolomics in faeces are categorised into four clusters based on the type of treatment. Tentative identification of significantly differing metabolites highlighted the presence of carbohydrate derivatives or conjugates (3-phenylpropyl glucosinolate and dTDP-D-mycaminose) in the quercetin group. The trans-resveratrol group was differentiated by compounds related to nucleotides (uridine monophosphate and 2,4-dioxotetrahydropyrimidine D-ribonucleotide). Marked associations between bacterial species (Clostridium genus) and the amount of some metabolites were identified. Moreover, trans-resveratrol and resveratrol-derived microbial metabolites (dihydroresveratrol and lunularin) were also identified. Accordingly, this study confirms the usefulness of omics-based techniques to discriminate individuals depending on the physiological effect of food constituents and represents an interesting tool to assess the impact of future personalized therapies.
Autores:
Saiz-Abajo, M. J. ; González-Ferrero, C.; Moreno-Ruíz, A.; et al.
Revista:
FOOD CHEMISTRY
ISSN:
0308-8146
Año:
2013
Vol.:
138
N°:
2-3
Págs.:
1581 - 1587
eta-Carotene is a carotenoid usually applied in the food industry as a precursor of vitamin A or as a colourant. beta-Carotene is a labile compound easily degraded by light, heat and oxygen. Casein micelles were used as nanostructures to encapsulate, stabilise and protect beta-carotene from degradation during processing in the food industry. Self-assembly method was applied to re-assemble nanomicelles containing beta-carotene. The protective effect of the nanostructures against degradation during the most common industrial treatments (sterilisation, pasteurisation, high hydrostatic pressure and baking) was proven. Casein micelles protected beta-carotene from degradation during heat stabilisation, high pressure processing and the processes most commonly used in the food industry including baking. This opens new possibilities for introducing thermolabile ingredients in bakery products.
Autores:
Romo, Ana; Yetano-Cunchillos, A. I. ; González-Ferrero, C.; et al.
Revista:
FOOD CHEMISTRY
ISSN:
0308-8146
Año:
2012
Vol.:
133
N°:
3
Págs.:
1045 - 1049
The objective of this work was to obtain and stabilize natural vitamins from red pepper by-products. The method of obtainment was supercritical carbon dioxide extraction, studying different parameters that affect the yield. The highest extraction yield was found at 60 degrees C, 24 MPa extraction, with no modifier added and 0.2-0.5 mm particle size. The recovered extract was a red-coloured oil. The extract was subsequently microencapsulated by spray-drying using gum arabic as wall material to avoid the degradation of vitamin over the storage time. The thermal stability of microcapsules was analysed by thermal gravimetric analysis (TGA), while size, shape and morphology of microcapsules were studied by scanning electron microscopy (SEM). The microcapsules containing pepper extract were particles of spherical shape with dents on the surface, the average size of these particles was 5.46 mu m. (C) 2012 Elsevier Ltd. All rights reserved.
Nacionales y Regionales
Título:
Aplicaciones del estudio multi-ómico de la microbiota al desarrollo de soluciones biotecnológicas innovadoras en el área de la salud (microBiomics)
Código de expediente:
0011-1411-2021-000106
Investigador principal:
María Teresa Herráiz Bayod
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2021 GN PROYECTOS ESTRATEGICOS DE I+D 2021-2024
Fecha de inicio:
15/04/2021
Fecha fin:
30/11/2023
Importe concedido:
366.577,17€
Otros fondos:
-
Título:
Implementación de estrategias para el cambio de hábitos alimentarios basadas en el control de la ración: desarrollo metodológico y estudio piloto
Código de expediente:
0011-1383-2022-000015 (PC139-140 PORTIONS 4)
Investigador principal:
Eva Almirón Roig
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2022 GN Proyectos Colaborativos
Fecha de inicio:
01/12/2022
Fecha fin:
30/11/2024
Importe concedido:
186.578,25€
Otros fondos:
-
Título:
Aplicación de agentes paraprobióticos y postbióticos en la prevención y tratamiento de la obesidad. Mecanismos implicados.
Código de expediente:
0011-1383-2022-000015 (PC128-129 PARABIOTICS
Investigador principal:
Paula Aranaz Oroz
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2022 GN Proyectos Colaborativos
Fecha de inicio:
01/12/2022
Fecha fin:
30/11/2024
Importe concedido:
251.608,88€
Otros fondos:
-
Título:
EHGNA: Desarrollo de Algoritmos de respuesta al tratamiento nutricional frente a la EHGna: integración de datos mediante inteligencia artificial
Código de expediente:
0011-1383-2020-000010 PC082 EHGNA
Investigador principal:
Itziar Abete Goñi
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2020 GN Proyectos Colaborativos
Fecha de inicio:
01/12/2019
Fecha fin:
30/11/2022
Importe concedido:
193.350,00€
Otros fondos:
-
Título:
USO DE LA BIOTECNOLOGÍA PARA LA OBTENCIÓN DE INGREDIENTES Y ALIMENTOS BENEFICIOSOS PARA LA SALUD (BIOFOOD)
Código de expediente:
0011-1411-2019-000031
Investigador principal:
Fermín Ignacio Milagro Yoldi
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2019 GN PROYECTOS ESTRATEGICOS DE I+D 2019-2021
Fecha de inicio:
01/07/2019
Fecha fin:
30/11/2021
Importe concedido:
238.952,30€
Otros fondos:
-
Título:
Alimentación para la infancia saludable, accesible y asequible (ALINFA)
Código de expediente:
0011-1411-2019-000033
Investigador principal:
Santiago Navas Carretero
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2019 GN PROYECTOS ESTRATEGICOS DE I+D 2019-2021
Fecha de inicio:
01/07/2019
Fecha fin:
30/11/2021
Importe concedido:
237.463,67€
Otros fondos:
-
Título:
PREDISMET Estudio de la potencial aplicación de una combinación de probióticos, prebióticos y postibióticos para la prevención y tratamiento de la disbiosis intestintal caracterísstica del síndrome metabólico.
Código de expediente:
0011-1383-2020-000010 PC173 predismet
Investigador principal:
Paula Aranaz Oroz
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2020 GN Proyectos Colaborativos
Fecha de inicio:
01/06/2020
Fecha fin:
30/11/2022
Importe concedido:
296.051,13€
Otros fondos:
-
Título:
MICROLIVER La mircobiota intestintal y los probióticos como nuevos abordajes de la esteatosis hepática, gracias al desarrollo de un dispositivio para el análisis de microbiota en las diferentes zonas del tracto digestivo.
Código de expediente:
0011-1383-2020-000010 PC131 MICROLIVER
Investigador principal:
Fermín Ignacio Milagro Yoldi
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2020 GN Proyectos Colaborativos
Fecha de inicio:
01/06/2020
Fecha fin:
30/11/2022
Importe concedido:
408.589,75€
Otros fondos:
-
Título:
MODULACIÓN PERSONALIZADA DE LA MICROBIOTA MEDIANTE EL DISEÑO INTELIGENTE DE ALIMENTOS E INGREDIENTES A PARTIR DEL DIAGNÓSTICO BASADO EN ENTEROTIPOS (NUTRIBIOTA)
Código de expediente:
0011-1411-2018-000040
Investigador principal:
Fermín Ignacio Milagro Yoldi
Financiador:
GOBIERNO DE NAVARRA
Convocatoria:
2018 GN PROYECTOS ESTRATEGICOS DE I+D 2018-2020
Fecha de inicio:
01/05/2018
Fecha fin:
30/11/2020
Importe concedido:
477.778,14€
Otros fondos:
-
Título:
Mecanismos por los que la microbiota intestinal previene el riesgo de obesidad: posbióticos y miRNAs de origen microbiano y alimentario
Código de expediente:
RTI2018-102205-B-100
Investigador principal:
José Ignacio Riezu Boj, Fermín Ignacio Milagro Yoldi
Financiador:
MINISTERIO DE CIENCIA E INNOVACIÓN
Convocatoria:
2018 AEI - MCIU - Retos Investigación
Fecha de inicio:
01/01/2019
Fecha fin:
30/09/2022
Importe concedido:
121.000,00€
Otros fondos:
Fondos FEDER
Otros (PIUNA, fundaciones, contratos…)
Título:
CIEN BIOPRO MA
Investigador principal:
Paula Aranaz Oroz
Fecha de inicio:
01/11/2017
Fecha fin:
31/10/2021
Importe:
35.000,00€
Otros fondos:
-
Título:
CIEN BIOPRO UV
Investigador principal:
Paula Aranaz Oroz
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
13.000,00€
Otros fondos:
-
Título:
CIEN BIOPRO MAT
Investigador principal:
Paula Aranaz Oroz
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
17.750,00€
Otros fondos:
-
Título:
CIEN BIOPRO KM
Investigador principal:
Paula Aranaz Oroz
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
37.500,00€
Otros fondos:
-
Título:
CIEN BIOPRO EL
Investigador principal:
Paula Aranaz Oroz
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
38.000,00€
Otros fondos:
-
Título:
CIEN BIOTAGUT POS
Investigador principal:
Santiago Navas Carretero, Carlos Javier González Navarro, Ana Romo Hualde, Fermín Ignacio Milagro Yoldi
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
37.200,00€
Otros fondos:
-
Título:
Modulación del microbioma y del postbioma mediante el diseño
Investigador principal:
Fermín Ignacio Milagro Yoldi
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
30.990,00€
Otros fondos:
-
Título:
CIEN BIOTAGUT O
Investigador principal:
Fermín Ignacio Milagro Yoldi
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
6.000,00€
Otros fondos:
-
Título:
CIEN BIOTAGUT KM
Investigador principal:
Fermín Ignacio Milagro Yoldi
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
45.620,00€
Otros fondos:
-
Título:
CIEN BIOTAGUT A
Investigador principal:
Fermín Ignacio Milagro Yoldi
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
114.540,00€
Otros fondos:
-
Título:
CIEN BIOTAGUT SK
Investigador principal:
Fermín Ignacio Milagro Yoldi
Fecha de inicio:
01/11/2017
Fecha fin:
31/12/2021
Importe:
49.287,00€
Otros fondos:
-