Nuestros investigadores

María Soledad García Unciti

Departamento
Ciencias de la Alimentación y Fisiología
Facultad de Farmacia y Nutrición. Universidad de Navarra
. Clínica Universidad de Navarra
Líneas de investigación
Alimentación, ejercicio físico y salud, Inflamación y obesidad, Nutrición y dietética hospitalaria, Dietética y nutrición en restauración colectiva

Publicaciones científicas más recientes (desde 2010)

Autores: Landecho Acha, Manuel Fortún (Autor de correspondencia); Alegría-Murillo, L.; López-Fidalgo, J.; et al.
Revista: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
ISSN 0014-2972  Vol. 50  Nº 11  2020  págs. e13307
Background: Obesity is a major public health problem, which continues to be diagnosed and classified by BMI, excluding the most elemental concepts of the precision medicine approach. Obesity does not equally affect males and females, even with the same BMI. Microalbuminuria is a risk marker of cardiovascular disease closely related to obesity. The aim of this study was to evaluate the gender-dependent differences in the development of early obesity-related disease, focusing on pathologic microalbuminuria (PMA). Material and methods: We developed a single-centre cross-sectional study including 1068 consecutive adults from May 2016 to January 2018, divided into two groups: one including the first 787 patients attended, evaluated as a description population; the second group included 281 subjects analysed as an external validation population. Collected data included medical history, anthropometric measures, abdominal bioimpedance and routine laboratory tests. Results: First, we confirmed the lack of accuracy of classic obesity measures in predicting microalbuminuria. Second, we tested the utility of a tailored evaluation to predict PMA, with an area under the ROC curve of 0.78 for females and 0.82 for males. We also confirmed the different physiology of visceral adiposity for males when compared to females, in which small variations of fat mass entail major changes in the clinical repercussion. Third, we performed an external validation of our results, achieving a 77% accuracy rate. Conclusions: Our findings support that there is an individual threshold of fat amount necessary to develop obesity-dependent PMA and that gender plays a major role in the interplay between PMA and adiposity.
Autores: Landecho Acha, Manuel Fortún; Sunsundegui Seviné, Patricia; Beloqui Ruiz, Óscar María; et al.
Revista: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
ISSN 0014-2972  Vol. 48  Nº Supl. 1  2018  págs. 210 - 211
Autores: Ibáñez Santos, Javier; Madariaga, I.; Grijalba, A.; et al.
Revista: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
ISSN 0195-9131  Vol. 44  Nº Suppl. 2  2012  págs. 583
Autores: García Unciti, María Soledad; Izquierdo, M.; Idoate, F.; et al.
Revista: ANNALS OF NUTRITION AND METABOLISM
ISSN 0250-6807  Vol. 61  Nº 4  2012  págs. 296 - 304
Background/Aims: A weight-loss diet alone or combined with a progressive resistance training program induced different adaptations on cardiometabolic risk, i.e. regional changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volume distribution patterns. We hypothesized that a heterogeneous adipose tissue metabolism may exist between visceral fat at different discal levels. Methods: Thirty-four obese women, aged 40-60 years, were randomized to three groups: a control group (n = 9), a diet group (WL; n = 12) with a caloric restriction of 500 kcal/day during 16 weeks, or a diet-plus-resistance-training group (WL+RT; n = 13) with the same caloric restriction and a 16-week resistance training of 2 sessions per week. Results: The association pattern between abdominal fat depots and glucose metabolism variables showed a change from the L4-L5 region (preintervention) to VAT L2-L3 and SAT L2-L3 in the WL and WL+RT groups, respectively. It is noteworthy that accumulation of fat in the midthigh was not characterized by a more favorable lipid profile or glucose metabolism. Conclusion: Our results reinforce the importance of considering L2-L3 images to predict insulin resistance after a weight-loss diet, alone or combined with resistance training.
Autores: García Unciti, María Soledad; Martínez Hernández, Alfredo; Izquierdo, M; et al.
Revista: NUTRICION HOSPITALARIA
ISSN 0212-1611  Vol. 27  2012  págs. 1511-1520
Lifestyle changes such as following a hypocaloric diet and regular physical exercise are recognized as effective non-pharmacological interventions to reduce body fat mass and prevent cardiovascular disease risk factors.PURPOSE:To evaluate the interactions of a higher protein (HP) vs. a lower protein (LP) diet with or without a concomitant progressive resistance training program (RT) on body composition and lipoprotein profile in hypercholesterolemic obese women.METHODS:Retrospective study derived from a 16-week randomized controlled-intervention clinical trial. Twenty five sedentary, obese (BMI: 30-40 kg/m²) women, aged 40-60 with hypercholesterolemia were assigned to a 4-arm trial using a 2 x 2 factorial design (Diet x Exercise). Prescribed diets had the same calorie restriction (-500 kcal/day), and were categorized according to protein content as: lower protein (< 22% daily energy intake, LP) vs. higher protein (> 22% daily energy intake, HP). Exercise comparisons involved habitual activity (control) vs. a 16-week supervised whole-body resistance training program (RT), two sessions/wk. RESULTS: A significant decrease in weight and waist circumference was observed in all groups. A significant decrease in LDL-C and Total-Cholesterol levels was observed only when a LP diet was combined with a RT program, the RT being the most determining factor. Interestingly, an interaction between diet and exercise was found concerning LDL-C values. CONCLUSION:In this study, resistance
Autores: Pérez Cidriain, Sarai; Sánchez-Campayo, E.; Sáenz Grandes, Cristina; et al.
Revista: REVISTA ESPAÑOLA DE NUTRICION HUMANA Y DIETETICA
ISSN 2173-1292  Vol. 15  Nº 3  2011  págs. 136
Autores: Idoate, F.; Ibáñez, J.; Gorostiaga, E.; et al.
Revista: INTERNATIONAL JOURNAL OF OBESITY
ISSN 0307-0565  Vol. 35  Nº 5  2011  págs. 700 - 713
Background: Quantification of abdominal fat and its regional distribution has become increasingly important in assessing the cardiovascular risk. Objective: To examine the effects of 16 weeks of a hypocaloric diet with a caloric restriction of 500 Kcal per day (WL) or the same dietary intervention plus resistance training (WL+RT) on regional variation of abdominal visceral (visceral adipose tissue (VAT)) and subcutaneous (subcutaneous adipose tissue (SAT)) fat loss. Second, to identify the single-image that best represents total magnetic resonance imaging measurements of total VAT and SAT volume before and after WL or WL+RT intervention. Design: A total of 34 obese (body mass index: 30-40 kg m(-2)) women, aged 40-60 years, were randomized to three groups: a control group (C; n = 9), a diet group (WL; n = 12) and a diet plus resistance training group (WL+RT; n = 13) with the same caloric restriction as group WL and a 16-week supervised whole-body RT of two sessions per week. Results: WL+RT programs lead to significant changes in the location of highest mean VAT area from L3-L4 to L2-L3 discal level from pre- to post- intervention, whereas after WL the greatest relative VAT losses were located at L5-S1. Similar decreases in the SAT areas at all discal levels were observed after WL and WL+RT. Conclusion: Different weight loss regimes may lead to different distribution of VAT. Sites located significantly above (cranial to) L4-L5 (that is, ~ 5-6 cm above L4-L5 or at L2-L3 discal level) provided superior prediction of total abdominal VAT volume, whereas more caudal slices provide better prediction of subcutaneous fat, not only before but also after either WL or WL+RT.
Autores: Goñi Mateos, Leticia; Macías Mendizábal, Elena; Cabezón Malo, Soraya; et al.
Revista: NUTRICION HOSPITALARIA
ISSN 0212-1611  Vol. 25  Nº Supl. 1  2010  págs. 148 - 149
Autores: García Unciti, María Soledad; Zazpe García, Itzíar; Ezquer Sanz, Leyre; et al.
Revista: NUTRICION HOSPITALARIA
ISSN 0212-1611  Vol. 25  Nº Supl. 1  2010  págs. 220
Autores: Ibañez, J; Izquierdo, M; Martínez-Labari, C; et al.
Revista: Obesity
ISSN 1469-3259  Vol. 18  Nº 3  2010  págs. 535 - 541
Increased circulating adiponectin and insulin sensitivity are usually observed after body fat loss induced by a weight-loss diet. Progressive resistance training (PRT) without a concomitant weight-loss diet significantly decreases visceral fat, thus improving insulin sensitivity. Therefore, the purpose of this study was to ascertain the effects of combined 16-week PRT and weight-loss diet on circulating adiponectin and insulin sensitivity index. Thirty-four obese (BMI: 30-40 kg/m(2)) women, aged 40-60 year, were randomized to three groups: a control group (C; n = 9); a diet group (WL; n = 12) with a caloric restriction of 500 kcal/d; and a diet plus resistance training group (WL+RT; n = 13) with the same caloric restriction as group WL and a 16-week supervised whole body PRT of two sessions/week. Both WL and WL+RT groups showed similar decreases in body mass (-6.3% and -7.7%) and visceral fat (-19.9% and -20.5%). WL resulted in an expected increase in circulating levels of adiponectin (P = 0.07) and insulin sensitivity. However, circulating total adiponectin decreased (P < 0.05) in WL+RT group, whereas an improvement in different cardiovascular risk factors (insulin sensitivity, low-density lipoprotein cholesterol (LDL-C), etc.) was observed. In conclusion, in obese women a 16-week combined PRT and weight-loss diet is accompanied by significant improvements in different cardiovascular risk factors in spite of a significant decrease of circulating adiponectin.
Autores: Cuervo Zapatel, Marta; García Unciti, María Soledad; Vidurrizaga de Amezaga, Carlos Antonio; et al.
Libro:  Alimentación, ejercicio físico y salud
2010  págs. 91 - 138
Autores: García Unciti, María Soledad
Libro:  Alimentación y deporte
2010  págs. 153 - 172
Autores: García Unciti, María Soledad; Cuervo Zapatel, Marta; Lacasa Arregui, Carlos; et al.
2011 
Material docente elaborado para la asignatura de Dietoterapia, en la Diplomatura de Nutrición Humana y Dietética, Doble titulación de Farmaciá y Nutrición, Grado en Nutrición y Dobbel Grado en Farmacia y Nutrición. Presenta contenidos teóricos y prácticos que sirven de apoyo para desarrollar los seminarios de la asignatura.
Autores: García Unciti, María Soledad; Gascón, E.; Pérez Cidriain, Sarai
2010 
Material docente elaborado para la asignatura de Dietoterapia, en la Diplomatura de Nutrición Humana y Dietética y Doble titulación de Farmaciá y Nutrición. Presenta contenidos teóricos, prácticos y problemas para resolver.
Autores: García Unciti, María Soledad (Editor); Zazpe García, Itzíar (Editor); Cabezón Malo, Soraya; et al.
2010 
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