Revistas
Revista:
FRONTIERS IN SURGERY
ISSN:
2296-875X
Año:
2021
Vol.:
8
Págs.:
673847
Background: Endolymphatic hydrops (EH) is the histopathological hallmark of Ménière's disease (MD) and has been found by in vivo magnetic resonance imaging (MRI) in patients with several inner ear syndromes without definite MD criteria. The incidence and relevance of this finding is under debate. Purpose: The purpose of the study is to evaluate the prevalence and characteristics of EH and audiovestibular test results in groups of patients with fluctuating audiovestibular symptoms not fulfilling the actual criteria for definite MD and compare them with a similar group of patients with definite MD and a group of patients with recent idiopathic sudden neurosensory hearing loss (ISSNHL). Material and Methods: 170 patients were included, 83 with definite MD, 38 with fluctuating sensorineural hearing loss, 34 with recurrent vertigo, and 15 with ISSNHL. The clinical variables, audiovestibular tests, and EH were evaluated and compared. Logistic proportional hazard models were used to obtain the odds ratio for hydrops development, including a multivariable adjusted model for potential confounders. Results: No statistical differences between groups were found regarding disease duration, episodes, Tumarkin spells, migraine, vascular risk factors, or vestibular tests; only hearing loss showed differences. Regarding EH, we found significant differences between groups, with odds ratio (OR) for EH presence in definite MD group vs. all other patients of 11.43 (4.5-29.02; p < 0.001). If the ISSNHL group was used as reference, OR was 55.2 (11.9-253.9; p < 0.001) for the definite MD group, 9.9 (2.1-38.9; p = 0.003) for the recurrent vertigo group, and 5.1 (1.2-21.7; p = 0.03) for the group with fluctuating sensorineural hearing loss. Conclusion: The percentage of patients with EH varies between groups. It is minimal in the ISSNHL group and increases in groups with increasing fluctuating audiovestibular symptoms, with a rate of severe EH similar to the known rate of progression to definite MD in those groups, suggesting that presence of EH by MRI could be related to the risk of progression to definite MD. Thus, EH imaging in these patients is recommended.
Revista:
ACTA OTO-LARYNGOLOGICA
ISSN:
0001-6489
Año:
2020
Vol.:
140
N°:
11
Págs.:
883-888
Background The main sequences used to assess degree of endolymphatic hydrops (EH) are the 3D- inversion-recovery (IR) with real reconstruction and the 3D- fluid-attenuated inversion recovery (FLAIR). Objectives The purpose of this study is to describe and compare both sequences. Material and methods Forty-two consecutive patients diagnosed with probable or definite Menier ' s disease were referred for hydrops MR examination. Vestibular and cochlear EH in both sequences were read by two independent radiologists, unaware of the patient's clinical status. The primary study endpoint was the concordance in the hydrops detection and severity with both imaging sequences. This was assessed using the Cohen's kappa Kappa statistic for disease grading and Pearson X(2)test to test the difference in detection rates of hydrops. Statistical significance was defined as two-sidedp < .05. Results We obtained an excellent overall concordance, with a kappa of 0.821, (p < .001) when comparing hydrops detection. The degree of concordance is higher in vestibular hydrops than in cochlear hydrops. The 3D-IR sequence detected more hydrops than the 3D FLAIR, (62 vs. 39.5%,p < .03). Conclusion The 3D-IR sequence seems to be superior to the 3D-FLAIR for the assessment of EH. Significance:The 3D-IR sequence should be considered as a standalone parameter for a shorter and optimized EH magnetic resonance imaging protocol.
Autores:
Guillan, M. (Autor de correspondencia); Villacieros-Alvarez, J.; Bellido, S. ; et al.
Revista:
THROMBOSIS RESEARCH
ISSN:
0049-3848
Año:
2020
Vol.:
193
Págs.:
107 - 109
Revista:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
ISSN:
1048-891X
Año:
2019
Vol.:
29
N°:
4
Págs.:
835 - 839
Revista:
RADIOLOGIA
ISSN:
0033-8338
Año:
2019
Vol.:
61
N°:
3
Págs.:
191 - 203
Magnetic resonance imaging has become a fundamental tool for the evaluation of head and neck tumors. The anatomic details that magnetic resonance images provide are fundamental for diagnosing, characterizing, and staging both primary tumors and lymph node metastases. In addition to technical improvements in anatomic sequences, such as Dixon techniques to improve fat suppression, other sequences being developed, such as diffusion and perfusion, provide molecular, biological, and physiological information about the tumor and are yielding imaging biomarkers that can help in determining the tumor's biology at the time of diagnosis and in the follow-up of the disease. Magnetic resonance imaging also provides very useful information about the response to treatment. (C) 2019 SERAM. Published by Elsevier Espana, S.L.U. All rights reserved.
Revista:
RADIOLOGIA
ISSN:
0033-8338
Año:
2018
Vol.:
60
N°:
5
Págs.:
387 - 393
Objective: Advances in clinical applications of computed tomography have been accompanied by improvements in advanced post-processing tools. In addition to multiplanar reconstructions, curved planar reconstructions, maximum intensity projections, and volumetric reconstructions, very recently kinematic reconstruction has been developed. This new technique, based on mathematical models that simulate the propagation of light beams through a volume of data, makes it possible to obtain very realistic three dimensional images. This article illustrates examples of kinematic reconstructions and compares them with classical volumetric reconstructions in patients with cardiovascular disease in a way that makes it easy to establish the differences between the two types of reconstruction. Conclusion: Kinematic reconstruction is a new method for representing three dimensional images that facilitates the explanation and comprehension of the findings. (C) 2018 SERAM. Published by Elsevier Espana, S.L.U. All rights reserved.
Nacionales y Regionales
Título:
Registro prospectivo de hipofraccionamiento con fotonterapia y protonterapia con sobreimpresion en zona GaPSMA positiva en el rescate tras prostatectomia
Código de expediente:
pi20/01598
Investigador principal:
Felix Mauricio Cambeiro Vázquez
Financiador:
INSTITUTO DE SALUD CARLOS III
Convocatoria:
2020 AES Proyectos de investigación
Fecha de inicio:
01/01/2021
Fecha fin:
31/12/2023
Importe concedido:
68.970,00€
Otros fondos:
Fondos FEDER
Título:
Descifrando la disociación de resultados en pruebas vestibulares de pacientes con enfermedad de Méniere unilateral
Código de expediente:
PI19/00414
Investigador principal:
Nicolás Pérez Fernández
Financiador:
INSTITUTO DE SALUD CARLOS III
Convocatoria:
2019 AES Proyectos de investigación
Fecha de inicio:
01/01/2020
Fecha fin:
31/12/2022
Importe concedido:
68.970,00€
Otros fondos:
Fondos FEDER
Otros (PIUNA, fundaciones, contratos…)
Título:
Nuevas técnicas para valoración de respuesta a la neoadyuvancia en el cáncer de mama. ¿Se podrá evitar la cirugía en pacientes con respuesta completa?
Financiador:
UNIVERSIDAD DE NAVARRA
Convocatoria:
2020 Convocatoria PIUNA
Fecha de inicio:
01/09/2020
Fecha fin:
31/08/2022
Importe concedido:
12.000,00€