Revistas
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2023
Vol.:
114
N°:
3
Págs.:
187 - 193
Background and objectives: The neurofibromatosis 1 (NF1) diagnosis is challenging in young children without a family history of NF1. The aims of this study were to estimate diagnostic delays in children without a family history of NF1 and to examine the effects of using cafe au lait macules and skin fold freckling as a single diagnostic criterion. Patients and methods: Retrospective, descriptive, observational study of all patients diagnosed with NF1 before the age of 18 years who were seen at our hospital. The medical records of those included were reviewed to identify the date on which the diagnostic criteria of NF1 were objectified. The patients were categorized into 2 groups: those with a known parental history of NF1 and those without. Cafe au lait macules and skin fold freckling were assessed as a single diagnostic criterion, and genetic evidence was considered to confirm highly suspicious cases. Results: We studied 108 patients younger than the age of 18 years with a diagnosis of NF1. Mean (SD) age at diagnosis was 3.94 (+/- 3.8) years for the overall group, 1 year for patients with a parental history of NF1, and 4 years and 8 months for those without. Diagnosis was therefore delayed by 3 years and 8 months in patients without a family history. Conclusion: Skin lesions were the first clinical manifestation of NF1 in most patients. We believe that the National Institutes of Health's diagnostic criteria for NF1 should be updated to aid diagnosis in young children. (c) 2022 AEDV. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Revista:
MEDICINA CLINICA
ISSN:
0025-7753
Año:
2023
Vol.:
160
N°:
8
Págs.:
367 - 368
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2023
Vol.:
21
N°:
7
Págs.:
792 - 794
Revista:
JOURNAL OF ULTRASOUND
ISSN:
1971-3495
Año:
2022
Vol.:
25
N°:
3
Págs.:
729 - 732
Eccrine spiradenoma is a rare, benign, adnexal skin tumor of the sweat gland. It is frequently solitary and presents as a small lesion in the dermal or the subcutaneous fat layer. Eccrine spiradenomas rarely progress to malignant transformation but they can relapse. Due to its rarity, there have been few reports about the sonographic appearances of eccrine spiradenoma. Sonographic findings were reported in a relapsing case of an eccrine spiradenoma, located in the deep dermal layers and hypodermis of the preauricular region in a middle-aged man. Ultrasound was very useful to suspect the relapse. Histology was correlated with the sonography and discussed the previously reported imaging findings of eccrine spiradenoma and other sweat gland tumors.
Revista:
JOURNAL OF ULTRASOUND
ISSN:
1971-3495
Año:
2022
Vol.:
25
N°:
2
Págs.:
289 - 295
Purpose Diagnosis of granuloma annulare (GA) is based on the clinical and histopathological findings. However, only sporadic case reports of subcutaneous GA sonography have been published to date. The objective of this study was to evaluate the ultrasonographic patterns of the different clinical variants of GA: localized, generalized, subcutaneous, and perforating. Methods In this retrospective observational study, we analyzed and correlated the clinical, histopathological, and sonographic features of 15 patients diagnosed with GA. Results We included 8 women and 7 men with a mean age of 48.4 years (8-77 years). We found three different sonographic patterns depending on the clinical variant of GA: poorly defined hypoechoic band including the dermis (dermal pattern), irregularly shaped hypoechoic hypodermal lumps (hypodermal pattern), and ill-defined hypoechoic dermal and subcutaneous lesions (mixed pattern). Five cases showed increased blood flow signal on Doppler interrogation. Conclusion Although our findings are broadly consistent with the previous reports of subcutaneous GA, the sonographic features in localized, generalized, and perforating GA have not been previously reported.
Revista:
ULTRASCHALL IN DER MEDIZIN
ISSN:
0172-4614
Año:
2021
Vol.:
44
N°:
2
Págs.:
e118 - e125
Purpose: High-frequency ultrasound allows the accurate identification of neurofibromas in neurofibromatosis type 1 (NF1). This study aimed to analyze the ultrasound features of neurofibromas in children with NF1, to establish a classification based on the clinical and sonographic patterns of the different types of neurofibromas, and to evaluate the interobserver correlation coefficient (¿) of this classification.
Materials and methods: In this prospective, single referral center observational study, clinical and ultrasound findings of neurofibromas in children diagnosed with NF 1 were analyzed. To identify the ultrasound patterns, a cluster analysis allowing the inclusion of both clinical and ultrasound data was designed. The ¿ coefficient was calculated using 9 external evaluators.
Results: 265 ultrasound scans were performed on a total of 242 neurofibromas from 108 children diagnosed with NF1. Cluster analysis allowed the identification of 9 patterns (Snedecor's F, P < 0.001) classified as "classic" cutaneous neurofibroma, blue-red neurofibroma, pseudoatrophic neurofibroma, nodular subcutaneous neurofibroma, diffuse subcutaneous neurofibroma, congenital cutaneous neurofibroma, congenital plexiform neurofibroma, congenital diffuse and plexiform neurofibroma, and subfascial neurofibroma. The ¿ coefficient of the interobserver ratings was 0.82.
Conclusion: Patterns identified in the cluster analysis allow neurofibromas to be classified with a very high interobserver correlation.
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2021
Vol.:
19
N°:
1
Págs.:
73 - 80
Background and objective: Clinicopathological features of cutaneous neurofibromas presenting as large irregularly shaped congenital cafe-au-lait macules (CALM) in Neurofibromatosis type 1 (NF1) patients have not been well characterized. We aimed to analyze the histopathological findings of large "atypical" CALM in children with NF1. Patients and Methods: this retrospective observational study we analyzed histopathological and immunostaining features of 21 biopsy specimens from 18 large hyperpigmented macules with irregular borders with or without hypertrichosis present during the first months of life in NF1 diagnosed children. Results: Of the 21 biopsies, ten showed a diffuse neurofibroma pattern and four exhibited characteristics of plexiform neurofibroma (PNF). In twelve specimens we observed groups of fusiform cells arranged linearly mimicking a small caliber nerve trunk with abnormal morphology. Repeated biopsies from two of these lesions performed at different ages showed transformation to a plexiform pattern. An increased interstitial cellularity was observed in 17 samples that was more evident around eccrine glands in 16 or accompanying hair follicles and vascular structures in twelve samples. All these cells had immunoreactivity for S100-protein, CD68 and were Melan-A positive in 15 samples. Conclusion: Clinicopathological findings of congenital cutaneous neurofibromas provide early diagnostic clues of NF1 with high relevance for monitoring of these patients.
Revista:
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN:
0190-9622
Año:
2021
Vol.:
88
N°:
4
Págs.:
e163 - e164
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2021
Vol.:
19
N°:
3
Págs.:
448 - 450
Revista:
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN:
0190-9622
Año:
2021
Vol.:
84
N°:
4
Págs.:
1128 - 1130
Revista:
JOURNAL OF DERMATOLOGICAL TREATMENT
ISSN:
0954-6634
Año:
2021
Vol.:
32
N°:
3
Págs.:
286-290
Background and objectives: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the follicular unit characterized by recurrent, painful, skin lesions including inflammatory nodules, abscesses, tunnels, and mutilating scarring. Intralesional corticosteroids injection (ICI) for HS has received little attention in the scientific literature. We evaluate the clinical response of ICI in acute and chronic HS lesions and aim to identify new applications of ultrasound-assisted procedures in HS management. Patients and methods: An observational, retrospective, multicenter study of HS patients treated with ICI was conducted from January 1 to August 1, 2015. We collected 98 HS patients. A total of 135 individual lesions were infiltrated, including non-inflammatory nodules, inflammatory nodules abscesses and fistulous tracts. Results: Complete response was reached in 95 lesions (70.37%), 34 showed partial response (25.19%) and 6 (4.44%) were non-response. A total of 105 individual lesions underwent sonographic scan before ICI. Conclusion: Clinical experience supported the use of ICI for individual lesions. Our results showed that ICI is a useful treatment to control in acute and recalcitrant HS lesions. Response rates improve significantly if lesions are previously evaluated with HFUS.
Revista:
MEDICINA CLINICA
ISSN:
0025-7753
Año:
2021
Vol.:
156
N°:
3
Págs.:
140 - 141
Revista:
DERMATOLOGY
ISSN:
1018-8665
Año:
2020
Vol.:
236
N°:
1
Págs.:
46 - 51
Background: There is little evidence on the use of intralesional triamcinolone (ILT) for managing fistulous tracts in hidradenitis suppurativa (HS). Objective: To assess the clinical and ultrasound response to ILT for single fistulous lesions in HS patients. Methods: A prospective open-label study was conducted to assess response to ILT (40 mg/mL) for fistulous tracts in HS. Consecutive patients (Hurley II stage exclusively) presenting to our department were recruited from August 2016 to August 2018. They received a single injection of ILT as the sole treatment. Lesions were assessed clinically and by ultrasound at baseline and 90 days. Results: Of the 53 included HS patients with fistulous tracts, 36 (67.9%) were women, 30 (56.6%) were smokers, and 36 (67.9%) were obese or overweight (body mass index >= 25). Median Sartorius score was 9.0 (IQR 9.0-36.0), and median duration of the lesion treated was 6 months (IQR 3.0-12.0). Fistulous tracts were injected with 0.5 mL triamcinolone 40 mg/mL. Seven patients were lost to follow-up. At 90 days, 20 (43.5%) lesions showed clinical and ultrasound resolution, 13 (28.3%) showed only clinical resolution while persisting on ultrasound, and 13 (28.3%) persisted both clinically and on ultrasound. Mean clinical size decreased from 17.0 to 5.1 mm (p < 0.0001), while mean length on ultrasound decreased from 16.0 to 8.6 mm (p < 0.0001). Limitations: Small sample size and no control group. Conclusions: Our study suggests that ILT is beneficial for small fistulous tracts in HS.
Revista:
MEDICINA CLINICA
ISSN:
0025-7753
Año:
2020
Vol.:
155
N°:
7
Págs.:
319 - 320
Revista:
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
ISSN:
0926-9959
Año:
2020
Vol.:
34
N°:
3
Págs.:
619 - 623
Background Reconstruction of large auricular defects with full-thickness skin grafts (FTSG) is a commonly reported option, but less attention has focused on the advantages and indications of using split-thickness skin grafts (STSG) in the ear. Objective We sought to report our experience using STSG for repair of defects located on the auricular concave surfaces, highlighting the utility of choosing the adjacent hairy skin as donor site. Methods We performed a retrospective review of all Mohs micrographic defects on the auricular concave surfaces repaired with STSG obtained from the adjacent hairy skin, between January 2017 and July 2018 at our institution. Results A total of 16 patients with defects on the auricular concavities resulting from removal of non-melanoma skin cancer were reconstructed with STSG taken from the adjacent hairy skin. Only one patient experienced partial graft failure and no other complications were observed after 6-month follow-up. Conclusion Split-thickness skin grafts are suitable for reconstructing concave areas in the ear, providing good cosmetic results with a simple, cost-effective and easily reproducible technique. Choosing the adjacent hairy skin as a donor area shortens the operative and postoperative time, and allows the procedure to be performed in a single surgical field.
Revista:
PIEL
ISSN:
0213-9251
Año:
2019
Vol.:
34
N°:
3
Págs.:
175-179
Revista:
PIEL
ISSN:
0213-9251
Año:
2019
Vol.:
34
N°:
3
Págs.:
175 - 179
Autores:
Martorell A; Alfageme F; Vilarrasa-Rull E; et al.
Revista:
EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. JOURNAL
ISSN:
1468-3083
Año:
2019
Vol.:
33
N°:
11
Págs.:
2137-2142
Background: It has been reported that clinical evaluation consistently underestimates the severity of hidradenitis suppurativa (HS).
Objective: To determine the usefulness of ultrasound as a diagnostic tool in HS compared with clinical examination and to assess the subsequent modification of disease management.
Methods: Cross-sectional multicentre study. Severity classification and therapeutic approach according to clinical vs. ultrasound examination were compared.
Results: Of 143 HS patients were included. Clinical examination scored 38, 70 and 35 patients as Hurley stage I, II and III, respectively; with ultrasound examination, 21, 80 and 42 patients were staged with Hurley stage I, II and III disease, respectively (P < 0.01). In patients with stage I classification as determined by clinical examination, 44.7% changed to a more severe stage. Clinical examination indicated that 44.1%, 54.5% and 1.4% of patients would maintain, increase or decrease treatment, respectively. For ultrasound examination, these percentages were 31.5%, 67.1% and 1.4% (P < 0.01). Concordance between clinical and ultrasound intra-rater examination was 22.8% (P < 0.01); intra-rater and inter-rater (radiologist) ultrasound agreement was 94.9% and 81.7%, respectively (P < 0.01).
Limitations: The inability to detect lesions that measure ¿0.1 mm or with only epidermal location.
Conclusion: Ultrasound can modify the clinical staging and therapeutic management in HS by detecting subclinical disease.
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2018
Vol.:
109
N°:
6
Págs.:
547 - 548
Autores:
Poveda I; Vilarrasa, Eva; Martorell, Antonio; et al.
Revista:
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
ISSN:
1175-0561
Año:
2018
Vol.:
19
N°:
5
Págs.:
771-777
Background: Serum zinc levels in patients with hidradenitis suppurativa (HS) have not been previously studied.
Objective: The aim was to investigate the association between HS and serum zinc levels.
Methods: A multicenter, prospective clinical and analytical case-control study was designed to assess the possible association between HS and serum zinc levels. Consecutive patients with moderate or severe HS (Hurley II or III exclusively) were enrolled. A control population was recruited from primary care clinics. Fasting blood samples were extracted from each patient and serum zinc levels determined. Candidate predictors for low serum zinc levels were determined using logistic regression models.
Results: In total, 122 patients with HS and 122 control subjects were studied. Of the 122 HS patients, 79 (64.8%) were Hurley II and 43 (35.2%) were Hurley III. Low serum zinc levels (¿ 83.3 µg/dL) were more prevalent in HS (adjusted odds ratio [ORa] 6.7, P < 0.001). After logistic regression analysis, low serum zinc levels were associated with Hurley III (ORa 4.4, P < 0.001), Dermatology Life Quality Index ¿ 9 (ORa 3.1, P = 0.005), number of affected sites ¿ 3 (ORa 2.4, P = 0.042), genital location (ORa 2.9, P = 0.009), and perineal location (ORa 2.5, P = 0.025).
Conclusion: Low serum zinc levels are more prevalent in HS than in a healthy population, an indicator that may also be associated with disease severity.
Autores:
Poveda, I. (Autor de correspondencia); Vilarrasa, E.; Martorell, A.; et al.
Revista:
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
ISSN:
1175-0561
Año:
2018
Vol.:
19
N°:
5
Págs.:
771 - 777
BackgroundSerum zinc levels in patients with hidradenitis suppurativa (HS) have not been previously studied.ObjectiveThe aim was to investigate the association between HS and serum zinc levels.MethodsA multicenter, prospective clinical and analytical case-control study was designed to assess the possible association between HS and serum zinc levels. Consecutive patients with moderate or severe HS (Hurley II or III exclusively) were enrolled. A control population was recruited from primary care clinics. Fasting blood samples were extracted from each patient and serum zinc levels determined. Candidate predictors for low serum zinc levels were determined using logistic regression models.ResultsIn total, 122 patients with HS and 122 control subjects were studied. Of the 122 HS patients, 79 (64.8%) were Hurley II and 43 (35.2%) were Hurley III. Low serum zinc levels (83.3 mu g/dL) were more prevalent in HS (adjusted odds ratio [ORa] 6.7, P<0.001). After logistic regression analysis, low serum zinc levels were associated with Hurley III (ORa 4.4, P<0.001), Dermatology Life Quality Index9 (ORa 3.1, P=0.005), number of affected sites3 (ORa 2.4, P=0.042), genital location (ORa 2.9, P=0.009), and perineal location (ORa 2.5, P=0.025).ConclusionLow serum zinc levels are more prevalent in HS than in a healthy population, an indicator that may also be associated with disease severity.
Revista:
PEDIATRIC DERMATOLOGY
ISSN:
0736-8046
Año:
2017
Vol.:
34
N°:
3
Págs.:
271-276
Background/objectives: Mosaic neurofibromatosis type 1 (MNF1) is a variant of neurofibromatosis type 1 (NF1) in which clinical manifestations are limited to one or several body segments. The objective was to characterize the cutaneous features and associated systemic findings in a cohort of children with MNF1.
Methods: We performed a retrospective study of 40 children diagnosed with MNF1 at the Department of Dermatology, Hospital Infantil Niño Jesús, Madrid, Spain, from January 1, 1986, to October 31, 2015.
Results: All patients had pigmentary changes, alone (n = 39) or in combination with neurofibromas (n = 1). Twenty-four cases fulfilling the definition of MNF1 had six or more café au lait spots with or without freckling within the affected segment. They all lacked any other National Institutes of Health criteria of NF1. No patient had juvenile xanthogranuloma (JXG) or nevus anemicus (NA). Two children with MNF1 had epilepsy and two others developed malignancy (Hodgkin's lymphoma and ganglioneuroblastoma).
Conclusions: Pigmentary changes are the most frequent presentation of MNF1 in children. MNF1 must be considered with segmentary distribution of freckling and café au lait spots. Other frequent cutaneous findings in NF1, such as JXG or NA, seem to be exceptional in MNF1. Although the possibility of systemic complications and cancer risk seem to be low, patients must be followed up.
Revista:
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
ISSN:
0213-005X
Año:
2017
Vol.:
35
N°:
8
Págs.:
536-537
Revista:
DERMATOLOGY ONLINE JOURNAL
ISSN:
1087-2108
Año:
2017
Vol.:
23
N°:
11
Págs.:
18 -
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2017
Vol.:
15
N°:
6
Págs.:
674-677
Autores:
Martorell, A. (Autor de correspondencia); Wortsman, J.; Alfageme, F.; et al.
Revista:
DERMATOLOGIC SURGERY
ISSN:
1076-0512
Año:
2017
Vol.:
43
N°:
8
Págs.:
1065-1073
Autores:
Martorell, A.; Wortsman, X. ; Alfageme, F. ; et al.
Revista:
DERMATOLOGIC SURGERY
ISSN:
1076-0512
Año:
2017
Vol.:
43
N°:
8
Págs.:
1065 - 1073
BACKGROUND Staging and monitoring of patients with hidradenitis suppurativa (HS) have been traditionally based on clinical findings. However, the physical examination may show important limitations because of its poor sensitivity for differentiating between different lesion subtypes, and its low sensitivity to define the disease's activity. OBJECTIVE To develop a consensus ultrasound (US) report that could summarize the relevant anatomical characteristics and staging of patients considering the experience of radiologists and dermatologists working on imaging of HS. METHODS A questionnaire on different aspects related to US examination in HS was performed. A working group, called DERMUS, composed of doctors from 9 countries who have been working in dermatologic US applied in patients with HS on a regular basis were included to evaluate the different items provided. RESULTS A consensus US report to evaluate HS patients was established. CONCLUSION The authors present the first attempt to define a HS standardized sonographic report. This model would be the first effort to include this imaging technique as the first elective medical test for staging and monitoring patients, which can support therapeutic decisions by providing earlier, objective, deeper, anatomical, and comparative evaluations in this difficult to treat disease.
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2016
Vol.:
107
N°:
7
Págs.:
603
Revista:
BRITISH JOURNAL OF DERMATOLOGY
ISSN:
0007-0963
Año:
2016
Vol.:
175
N°:
5
Págs.:
1101-1102
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2016
Vol.:
107
N°:
Suppl 2
Págs.:
13-20
Both hidradenitis suppurativa and Crohn disease are considered chronic inflammatory diseases due to immune dysregulation. The high prevalence of Crohn disease patients diagnosed with hidradenitis suppurativa suggests the existence of common pathogenic links. The present literature review analyses the similarities and differences in the pathogenesis of the two diseases, in the search for new research and knowledge targets.
Autores:
Castellanos-González, M. (Autor de correspondencia); Larraín, H.; Díaz Ley, B.; et al.
Revista:
PIEL
ISSN:
0213-9251
Año:
2016
Vol.:
31
N°:
7
Págs.:
458 - 462
Objective To analyse the cosmetic features of 12 gels used in clinical practice for acne treatment. Material and methods Observational and descriptive study in 50 patients evaluated in the Hospital del Sureste between February and April of 2015. The different gels were provided in a transparent container and the patients evaluated odour, colour, easy to extend, and whether the gel remained over the skin after its application, and the sticky sensation. The patients also gave an overall score to each gel. Results Statistically significant differences in the evaluation of the different gels. The odour and the sticky sensation over the skin are the two variables most taken into account when the cosmetic features are evaluated by the patients. Conclusion The general perception of the cosmetics features of different gels currently used for the treatment of acne varies significantly depending on the gel used.
Revista:
SEMERGEN
ISSN:
1138-3593
Año:
2016
Vol.:
43
N°:
1
Págs.:
34-42
Revista:
PEDIATRIC DERMATOLOGY
ISSN:
0736-8046
Año:
2015
Vol.:
32
N°:
3
Págs.:
342 - 347
Nevus anemicus (NA) is a cutaneous anomaly characterized by pale, well-defined patches with limited vascularization after rubbing. They are largely known to be associated with neurofibromatosis 1 (NF1) and have received little attention in the literature until recently. We sought to characterize the prevalence and clinical features of patients with NA and NF1. We conducted an observational prospective study of 99 children with NF1 at the Hospital Nino Jesus, Madrid, Spain, from January 1, 2012, through July 31, 2013, and reviewed three other series of patients with NF1 and NA recently reported. The prevalence of NA in children with NF1 ranged from 8.8% to 51%, being much more prevalent at younger ages. Prospective studies yielded a higher prevalence than retrospective studies. NA was located most commonly on the trunk, particularly on the anterior chest wall, and was often multiple. Patients with segmental NF1 or isolated cafe au lait spots rarely had NA, and NA was absent in other genodermatoses. The collection of data was not homogeneous in all studies. NA has a high prevalence in individuals with NF1 patients but seems to be absent in connection with other genodermatoses, therefore its presence can assist in the diagnosis of suspected cases of NF1. The subtle clinical appearance of NA makes its detection difficult, and physicians involved in the care of children with NF1 must be aware of its possible presence and significance.
Revista:
PEDIATRÍA EN ATENCIÓN PRIMARIA
ISSN:
1139-7632
Año:
2015
Vol.:
17
N°:
67
Págs.:
e205 - e207
La pigmentación de las papilas fungiformes (PPF) es considerada una condición fisiológica, cuya etiopatogenia es desconocida. La PPF es relativamente frecuente en pacientes de raza negra o asiática, pese a lo cual, no suele aparecer reflejada en los principales tratados de dermatología o pediatría. Su diagnóstico es sencillo y exclusivamente clínico, si se conoce la entidad.
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2015
Vol.:
106
N°:
Supl. 1
Págs.:
76 - 86
Cutaneous ultrasound is particularly useful in pediatric dermatology to diagnose numerous diseases without the need to use invasive tests. The present articles reviews some frequent dermatological entities in children whose study can be simplified through cutaneous ultrasound. This article also provides practical recommendations reported in the literature that may facilitate ultrasound examination, with special mention of benign tumourat disease, both congenital and acquired, and vascular anomalies.
Revista:
MEDICINA CUTANEA IBERO-LATINO-AMERICANA
ISSN:
0210-5187
Año:
2015
Vol.:
43
N°:
Supl. 1
Págs.:
38 - 40
Lichen planus distribution along the Blaschko lines is rare and in most cases the unknown triggering factor. We present the case of a 50-year white woman clinically and histopathologically diagnosed of blaschkoid lichen planus. This dermatosis was affecting only the left side of the body and seems to be related to the vaccine against influenza virus administered two weeks before the onset of symptoms.
Autores:
Espasandín-Arias, M. (Autor de correspondencia); Vázquez-Osorio, I.; García-Martínez, F.J.; et al.
Revista:
CONTACT DERMATITIS
ISSN:
0105-1873
Año:
2014
Vol.:
71
N°:
1
Págs.:
57 - 58
Autores:
López Martín, I. (Autor de correspondencia); Benito Ortíz, L.; Rodríguez Borlado, B.; et al.
Revista:
SEMERGEN
ISSN:
1138-3593
Año:
2014
Vol.:
41
N°:
2
Págs.:
70 - 75
Introduction: Limited joint mobility syndrome (LJMS) appears exclusively in both type 1 and type 2 diabetic patients. It is characterized by a limited range of digital motion, with involvement of small joints of the hands. It initially affects the proximal interphalangeal joints, followed by wrists, elbows, shoulders, knees, and axial skeleton. The diagnosis can be made by the simple «prayer sign» test. The objective was to study the prevalence of diabetic patients with LJMS, and to evaluate the association between LJMS and metabolic control, and the risk of accidental falls. Patients and methods: A cross-sectional study was conducted in the San Fernando II Health Centre, Madrid (suburbs). The sample consisted of 184 patients with a diagnosis of diabetes of over 5 years from November to March, 2013. The prayer sign was used to define which patients had LJMS. Fall risk was determined using the Timed Up & Go test. Results: A total of 99 patients (53.8%) (95% CI 46.6 to 61) had a positive prayer sign. No statistically significant relationship was found with HbA1c, but there was an association with the Timed Up & Go test (P<.001) (95% CI 1.173 to 1.611). The patients with LJMS had a moderate risk of falls compared with those without LJMS, which was of low risk. Conclusions: The prevalence of LJMS is high. This is the first study that shows a relationship between LJMS and the risk of falls in diabetic patients. © 2013 Sociedad Española de Médicos de Atención Primaria (SEMERGEN).
Revista:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
ISSN:
0307-6938
Año:
2014
Vol.:
39
N°:
7
Págs.:
813 - 815
Golimumab is a fully human anti-tumour necrosis factor (TNF)- monoclonal antibody approved for use in the treatment of active rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Psoriasis induced by treatment with anti-TNF drugs is well documented, but to our knowledge, the development of clinical features of psoriasiform exfoliative erythroderma during treatment with golimumab has not been previously described.
Autores:
Vázquez-Osorio, I. (Autor de correspondencia); Salgado-Boquete, L.; Espasandín-Arias, M.; et al.
Revista:
INTERNATIONAL JOURNAL OF DERMATOLOGY
ISSN:
0011-9059
Año:
2014
Vol.:
53
N°:
9
Págs.:
e389 - e390
Revista:
DERMATOLOGY
ISSN:
1018-8665
Año:
2013
Vol.:
227
N°:
3
Págs.:
238 - 242
X-linked dominant protoporphyria (XLDPP) is a genetic disorder that affects the synthesis of the heme group due to an increase in delta-aminolaevulinate synthase 2 (ALAS2) enzyme activity. Moreover, annular elastolytic giant-cell granuloma (AEGCG) is a rare reactive granulomatous dermatosis, usually associated with actinic damage. An 86-year-old man presented with edematous-erythematous lesions in photoexposed areas of the face and on the dorsum of both hands. Protoporphyrin levels in serum and feces were significantly elevated and a heterozygous frameshift mutation in the exon 11 of the ALAS2 gene: c.1706-1709del (p.Glu-569GlyfsX24) was identified. Concomitantly, we observed an annular plaque with raised borders on the back of his right hand, clinically and histologically compatible with a diagnosis of AEGCG. Skin lesions disappeared only upon use of a physical sunscreen. We report two rare photodermatoses in an elderly patient and discuss the significance of dermal elastic fiber damage induced by the XLDPP as a main triggering factor of AEGCG.
Revista:
MEDICINA CLINICA
ISSN:
0025-7753
Año:
2013
Vol.:
141
N°:
6
Págs.:
276 - 277
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2012
Vol.:
103
N°:
5
Págs.:
437 - 452
Revista:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
ISSN:
0307-6938
Año:
2012
Vol.:
37
N°:
7
Págs.:
755 - 758
Scleroderma-like cutaneous changes have been reported in association with several drugs, but not with hydroxyurea (HU), to our knowledge. We report the case of a 67-year-old man who was treated with HU (hydroxycarbamide) for 12 years for a myeloproliferative disorder, and presented a progressive pruritic woody induration, symmetrically affecting both legs. He also had Gottron-like papules on the back of the metacarpophalangeal joints, and a retroauricular undifferentiated squamous cell carcinoma. On histological examination of a skin biopsy taken from the leg, massive dermal fibrosis was seen, with thickening of collagen bundles throughout the entire dermis. Six months after HU withdrawal, the skin induration resolved without scarring. Scleroderma-like syndrome has not been previously considered one of the secondary effects of HU. The evolution of our patients condition supports a causal relationship between the HU treatment and the sclerodermiform changes of the skin.
Revista:
HERIDAS Y CICATRIZACIÓN
ISSN:
2171-8644
Año:
2012
Vol.:
9
N°:
3
Págs.:
40 - 43
Revista:
PHOTODERMATOLOGY PHOTOIMMUNOLOGY AND PHOTOMEDICINE
ISSN:
0905-4383
Año:
2011
Vol.:
27
N°:
5
Págs.:
245 - 247
Systemic photosensitivity due to the intake of plants or herbal compounds is a rare phenomenon. Goji berries are widely used as a well-being and anti-aging remedy. In spite of this, only a few adverse reactions and no cases of photosensitivity have been reported to date. A 53-year-old male consulted due to a pruriginous eruption located on sun-exposed areas of 2 weeks of duration. He had been taking Goji berries and infusions of cat's claw herb for 5 and 3 months, respectively. Minimal erythema dose for UVB (MED-UVB) was diminished when the patient was taking these products, and became normal when they were withdrawn. Photoprovocation tests with Goji berries and cat's claw were performed. MED-UVB decreased after the intake of Goji berries, and was normal with cat's claw. We report the first case of systemic photosensitivity due to Goji berries.