Nuestros investigadores

Elisa Félix Soriano

Publicaciones científicas más recientes (desde 2010)

Autores: Gil Iturbe, Eva; Félix Soriano, Elisa; Sáinz Amillo, Neira; et al.
ISSN 1715-5312  Vol. 45  Nº 9  2020  págs. 957 - 967
Obesity is characterized by excessive fat accumulation and inflammation. Aging has also been characterized as an inflammatory condition, frequently accompanied by accumulation of visceral fat. Beneficial effects of exercise and 11-3 long-chain polyunsaturated fatty acids in metabolic disorders have been described. Glucose transporter 12 (GLUT12) is one of the less investigated members of the GLUT family. Glucose, insulin, and tumor necrosis factor alpha (TNF-alpha) induce GLUT12 translocation to the membrane in muscle, adipose tissue, and intestine. We aimed to investigate GLUT12 expression in obesity and aging, and under diet supplementation with docosahexaenoic acid (DHA) alone or in combination with physical exercise in mice. Aging increased GLUT12 expression in intestine, kidney, and adipose tissue, whereas obesity reduced it. No changes on the transporter occurred in skeletal muscle. In obese 18-month-old mice, DHA further decreased GLUT12 in the 4 organs. Aerobic exercise alone did not modify GLUT12, but the changes triggered by exercise were able to prevent the DHA-diminishing effect, and almost restored GLUT12 basal levels. In conclusion, the downregulation of metabolism in aging would be a stimulus to upregulate GLUT12 expression. Contrary, obesity, an excessive energy condition, would induce GLUT12 downregulation. The combination of exercise and DHA would contribute to restore basal function of GLUT12.
Autores: Escoté Miró, Xavier; Félix Soriano, Elisa; Gayoso Morandeira, Lucía; et al.
ISSN 2042-6496  Vol. 9  Nº 5  2018  págs. 3028 - 3036
FGF21 has emerged as a key metabolism and energy homeostasis regulator. Dietary supplementation with eicosapentaenoic acid (EPA) and/or -lipoic acid (LIP) has shown beneficial effects on obesity. In this study, we evaluated EPA and/or LIP effects on plasma FGF21 and the fatty acid (FA) profile in overweight/obese women following hypocaloric diets. At the baseline, FGF21 levels were negatively related to the AST/ALT ratio and HMW adiponectin. The weight loss did not cause any significant changes in FGF21 levels, but after the intervention FGF21 increased in EPA-supplemented groups compared to non-EPA-supplemented groups. EPA supplementation decreased the plasma n-6-PUFA content and increased n-3-PUFAs, mainly EPA and DPA, but not DHA. In the LIP-alone supplemented group a decrease in the total SFA and n-6-PUFA content was observed after the supplementation. Furthermore, EPA affected the desaturase activity, lowering 4D and raising 5/6D. These effects were not observed in the LIP-supplemented groups. Besides, the changes in FGF21 levels were associated with the changes in EPA, n-3-PUFAs, 5/6D, and n-6/n-3 PUFA ratio. Altogether, our study suggests that n-3-PUFAs influence FGF21 levels in obesity, although the specific mechanisms implicated remain to be elucidated.
Autores: Escoté Miró, Xavier; Huerta Hernández, Ana Elsa; Fernández Galilea, Marta; et al.
ISSN 0014-2972  Vol. 48  Nº Supl. 1  2018  págs. 206 - 206
Autores: Martínez Fernández, Leyre; Fernández Galilea, Marta; Félix Soriano, Elisa; et al.
Libro:  Obesity: Oxidative Stress and Dietary Antioxidants
2018  págs. 63 - 92
Autores: Félix Soriano, Elisa; Moreno Aliaga, María Jesús; Ramírez Gil, María Javier; et al.
Libro:  Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases
Nº 14  2018  págs. 223-238