Nuestros investigadores

Pedro Redondo Bellón

Publicaciones científicas más recientes (desde 2010)

Autores: Camarero-Mulas, C; Delgado Jiménez, Y; Sanmartín-Jiménez, O; et al.
Revista: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
ISSN 0926-9959  Vol. 32  Nº 1  2018  págs. 108 - 112
Background: The elderly population is increasing and more patients in this group undergo Mohs micrographic surgery (MMS). The few publications investigating MMS in elderly people conclude that it is a safe procedure; however, these are single-centre studies without a comparison group. Objective: To compare the characteristics of patients, tumours, MMS and 1-year follow-up in patients younger than 80 years, with patients older than 80 years at the time of surgery. Methods: Data was analysed from REGESMOHS, a prospective cohort study of patients treated with MMS. The participating centres were 19 Spanish hospitals where at least one MMS is performed per week. Data on characteristics of the patient, tumour and surgery were recorded. Follow-up data were collected from two visits; the first within 1 month postsurgery and the second within the first year. Results: From July 2013 to October 2016, 2575 patients that underwent MMS were included in the registry. Of them, 1942 (75.4%) were aged <80 years and 633 (24.6%) were ¿80 years old. In the elderly, the tumour size was significantly higher with a higher proportion of squamous cell carcinoma. Regarding surgery, elderly more commonly had tumours with deeper invasion and required a higher number of Mohs surgery stages, leaving larger defects and requiring more time in the operating room. Despite this, the incidence of postoperative complications was the same in both groups (7%) and there were no significant differences in proportion of relapses in the first-year follow-up. Conclusion: The risk of short-term complications and relapses were similar in elderly and younger groups. MMS is a safe procedure in the elderly.
Autores: Ivars, Marta; López-Gutiérrez JC; Redondo, P. ;
Revista: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN 0190-9622  Vol. 76  Nº 5  2017  págs. e155-e156
Autores: Redondo, P. ; Bernad, Isabel; Moreno-Artero, Ester; et al.
Revista: DERMATOLOGIC SURGERY
ISSN 1076-0512  Vol. 43  Nº 8  2017  págs. 1036 - 1041
BACKGROUND: The typical reconstructive option for closing large-sized defects of the distal half of the nose is the paramedian forehead flap. Other alternatives are a melolabial interpolation flap and bilobed or trilobed flaps. The dorsal nasal (Rieger) flap is suitable for closing small-sized defects at this location, especially when they are medially located. OBJECTIVE: The authors describe a modified dorsal nasal flap reconstruction for large nasal defects. The novelty of this study lies in lengthening the leading edge of flap rotation, which may provide tissue either from the adjacent nasal skin, the nasofacial groove, or the cheek. MATERIALS AND METHODS: The authors performed a retrospective chart review of all patients with large defects (>20 mm) of the nose who underwent modified dorsal nasal flap repair between January 2004 and March 2015 at a single academic center. RESULTS: Twenty-seven patients (16 male, 11 female; ages 44-88, mean age 62 years) had defects (the smallest 15 × 21 mm, and the largest 32 × 37 mm) on the lower portion of the nasal pyramid. Follow-up ranged from 12 months to 11 years with good or excellent results in all cases. CONCLUSION: Elongated dorsal nasal flap is a reproducible one-stage flap for large defects of the nose, with minimal risk of aesthetic or functional complications.
Autores: López-Gutiérrez, J. C.; Redondo, P. ; Ivars, Marta;
Revista: PEDIATRICS
ISSN 0031-4005  Vol. 140  Nº 1  2017  págs. e20162967
Although capillary malformations (CMs) are not usually serious health problems in themselves, they can occasionally be warning signs for syndromes with more serious or aggressive vascular malformations not readily apparent at birth or on initial examination. We describe a series of 9 patients with a common phenotype: (1) CM on the fingertips; (2) associated combined vascular (lymphatic-venous) malformations on the trunk and/or extremities; and (3) in some cases, partial overgrowth and asymmetry of the extremities. Data were collected retrospectively for patients with CM on the fingertips who were treated at 2 Vascular Anomalies Centers from January 2006 to January 2016. All the patients presented CM and other associated vascular abnormalities from birth. CMs were centripetal in their distribution. The greater the centripetal progression of the CM, the greater the associated vascular malformation observed. Some patients also presented varying degrees of overgrowth and asymmetry. At present, we have not found a patient with CM of the fingertip without associated anomalies. In conclusion, we present a series of patients with a particular morphology of CM located on the fingertips. All cases were associated with lymphatic-venous malformations at other sites. These data lead us to recommend these patients be referred from birth to a multidisciplinary unit of vascular anomalies.
Autores: Querol-Cisneros, E; Redondo, P. ;
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 108  Nº 7  2017  págs. 657 - 664
Introducción El principio básico de un colgajo lobulado o digitiforme de trasposición es que una vez que el tejido desplazado cubra el defecto, la zona dadora cierre directamente. Cuando los defectos son grandes puede ser necesaria la realización de un segundo lóbulo, debido a que el área que deja el primer lóbulo con su movimiento no cumple el criterio anterior. Con frecuencia se puede forzar el colgajo y adaptarlo al nuevo lecho, aunque a veces esta maniobra, sumada al cierre directo del tejido adyacente, puede traccionar en exceso y comprometer la vascularización. Material y métodos Se presenta una serie de 4 pacientes con tumores epiteliales en el lateral nasal. Tras la extirpación quirúrgica, los defectos resultantes se cubrieron mediante colgajos digitiformes de trasposición. En el diseño del cierre de los defectos se utilizaron unos puntos de sutura subcutáneos denominados en «cuerda de guitarra» para disminuir el tamaño del área cruenta y facilitar el ensamblaje del colgajo sin tensión. Conclusiones Proponemos la realización de la sutura subcutánea en «cuerda de guitarra» para aquellos casos en los que el defecto cutáneo es mayor que la cobertura que aporta el colgajo local, con el objetivo de facilitar su ensamblaje y disminuir el riesgo de necrosis del tejido desplazado por una excesiva tensión.
Autores: Tomás, Alejandra, (Autor de correspondencia); Redondo, P. ;
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 108  Nº 4  2017  págs. 282 - 292
Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization. The conclusion is that the difference in efficacy is clinically negligible (global estimate of the mean response rate difference, ¿3.69%; 95% CI, ¿6.54% to ¿0.84%). The adverse effects of daylight PDT are mild and localized (79% of patients report no discomfort), and patients report less pain (P < .001). Daylight PDT gives good to excellent cosmetic results in more than 90% of patients, and patient satisfaction is greater (P < .001).
Autores: Ivars, Marta; Redondo, P. ;
Revista: JAMA DERMATOLOGY
ISSN 2168-6068  Vol. 153  Nº 1  2017  págs. 103 - 105
Autores: Ballestin Rodriguez, C.; Redondo, P. ;
Revista: BRITISH JOURNAL OF SURGERY
ISSN 0007-1323  Vol. 104  Nº Supl. 1  2017  págs. 11
Autores: Bernad, Isabel; Redondo, P. ;
Revista: PIEL
ISSN 0213-9251  Vol. 31  Nº Supl 1  2016  págs. 8 - 9
Autores: Redondo, P. ; Cabrera, J.; et al.
Revista: VASOMED
ISSN 0942-1181  Vol. 28  Nº 4  2016  págs. 196 - 197
Autores: Baselga Torres, E.; Bernabeu Wittel, J.; van Esso Arbolave, D. L.; et al.
Revista: ANALES DE PEDIATRIA
ISSN 1695-4033  Vol. 85  Nº 5  2016  págs. 256 - 265
Introducción Los hemangiomas infantiles son tumores benignos producidos por la proliferación de células endoteliales de vasos sanguíneos, con una alta incidencia en niños menores de un año (4-10%) y se estima que un 12% de ellos requiere tratamiento. Dicho tratamiento debe realizarse según las guías de práctica clínica y la experiencia de los especialistas, las características de los pacientes y las preferencias de sus progenitores. Métodos El proceso de consenso se realizó utilizando evidencias científicas sobre el diagnóstico y tratamiento de los hemangiomas infantiles, extraídas mediante una revisión sistemática de la literatura, junto con el juicio experto de los especialistas. Las recomendaciones formuladas fueron validadas por los especialistas, aportando su grado de acuerdo. Resultados El presente documento recoge recomendaciones sobre la clasificación, las asociaciones, las complicaciones, el diagnóstico, el tratamiento y el seguimiento de los pacientes con hemangioma infantil. Además, se incluyen algoritmos de actuación y se aborda el manejo multidisciplinario y criterios de derivación entre los distintos especialistas que participan en el manejo clínico de este tipo de pacientes. Conclusiones Las recomendaciones y los algoritmos diagnóstico y terapéutico de los hemangiomas infantiles recogidos en este documento son una herramienta útil en el manejo adecuado de estos pacientes.
Autores: Gilaberte, Y., (Autor de correspondencia); Aguilar, M.; Almagro, M.; et al.
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106   Nº 8  2015  págs. 623 - 631
Introduction: Daylight-mediated photodynamic therapy (PDT) is a new type of PDT that is as effective as conventional PDT in grade 1 and 2 actinic keratosis but with fewer adverse effects, resulting in greater efficiency. The climatic conditions in the Iberian Peninsula require an appropriately adapted consensus protocol. Objective: We describe a protocol for the treatment of grade 1 and 2 actinic keratosis with daylight-mediated PDT and methyl aminolevulinate (MAL) adapted to the epidemiological and clinical characteristics of Spanish and Portuguese patients and the climatic conditions of both countries. Methods: Twelve dermatologists from different parts of Spain and Portugal with experience in the treatment of actinic keratosis with PDT convened to draft a consensus statement for daylight-mediated PDT with MAL in these countries. Based on a literature review and their own clinical experience, the group developed a recommended protocol. Results: According to the recommendations adopted, patients with multiple grade 1 and 2 lesions, particularly those at risk of developing cancer, are candidates for this type of therapy. Daylight-mediated PDT can be administered throughout the year, although it is not indicated at temperatures below 10°C or at excessively high temperatures. Likewise, therapy should not be administered when it is raining, snowing, or foggy. The procedure is simple, requiring application of a sunscreen with a protection factor of at least 30 based exclusively on organic filters, appropriate preparation of the lesions, application of MAL without occlusion, and activation in daylight for 2hours. Conclusion: This consensus statement represents a practical and detailed guideline to achieve maximum effectiveness of daylight-mediated PDT with MAL in Spain and Portugal with minimal adverse effects.
Autores: Redondo, P. ;
Revista: NEW ENGLAND JOURNAL OF MEDICINE
ISSN 0028-4793  Vol. 372  Nº 23  2015  págs. e31
An 82-year-old man presented with a 1-year history of swelling of his left ear, with associated difficulty hearing. He had applied topical glucocorticoids for 4 months without response. On examination, the ear was enlarged, indurated, and erythematous (Panel A), with no associated lymphadenopathy. Biopsy revealed chronic inflammatory infiltration in the dermis, with confluent epithelioid granulomas and a lymphocytic background. High magnification showed abundant intracytoplasmic amastigotes in dermal macrophages (Panel B). Leishmania infantum was identified by means of culture and polymerase-chain-reaction assay. No visceral enlargement was noted on ultrasonography of the abdomen. The patient was treated with amphotericin B, with complete resolution of the lesion after 2 months (Panel C) and recovery of hearing loss.
Autores: Moreno-Artero, Ester; Redondo, P. ;
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106  Nº 8  2015  págs. 658-65
The logarithmic spiral flap is useful for the closure of circular or oval defects situated on the lateral surface of the nose and nasal ala. The flap initiates at one of the borders of the wound as a pedicle with a radius that increases progressively to create a spiral. We propose the logarithmic spiral flap as an excellent option for the closure of circular or oval defects of the nose
Autores: Ruiz-Salas, V.; Garcés, J. R.; Miñano Medrano, R.; et al.
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106  Nº 7  2015  págs. 562 - 568
Introduction The Spanish registry of Mohs micrographic surgery started collecting data in July 2013. The aim of the registry is to report on the use of this technique in Spain and the outcomes achieved. In the present article, we describe the characteristics of patients and the tumors treated. Material and methods This is a prospective cohort study of patients treated with Mohs micrographic surgery. The participating centers are hospitals where at least one intervention of this type is performed each week. All patients considered for Mohs micrographic surgery in participating centers are included in the registry except those who have been declared legally incompetent. Results Between July 2013 and October 2014, data from 655 patients were included in the registry. The most common tumor involved was basal cell carcinoma, and the most common histological subtype was infiltrative basal cell carcinoma. Most of the tumors treated were located on the face or scalp, and the most common site was the nose. Almost 40% of the tumors treated were recurrent or persistent, and preoperative tumor size was similar to that reported in other European studies and in Australia. In total, 45.5% of patients had received previous surgical treatment. Conclusion The findings are similar to those reported in other studies, and the data collected are useful for assessing whether the results of studies carried out elsewhere are applicable in Spain.
Autores: Moreno-Artero, Ester; Redondo, P. ;
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106  Nº 8  2015  págs. 658-65
The logarithmic spiral flap is useful for the closure of circular or oval defects situated on the lateral surface of the nose and nasal ala. The flap initiates at one of the borders of the wound as a pedicle with a radius that increases progressively to create a spiral. We propose the logarithmic spiral flap as an excellent option for the closure of circular or oval defects of the nose.
Autores: Lacour, J. P. ; Ulrich, C. ; Gilaberte, Y. ; et al.
Revista: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
ISSN 0926-9959  Vol. 29  Nº 12  2015  págs. 2342 - 2348
Background Unmet needs exist in actinic keratosis (AK) treatment. Daylight photodynamic therapy (DL-PDT) has shown good efficacy and safety results compared to conventional PDT (c-PDT) in a recent Phase III multi-centre randomised controlled trial in Australia among 100 subjects with AKs. Objectives Demonstrate non-inferior efficacy and superior safety of DL-PDT compared to c-PDT in treating multiple mild and/or moderate facial/scalp AKs. Methods Phase III, 12 week, multi-centre, randomised, investigator-blinded, controlled, intra-individual study conducted at different latitudes in Europe. AKs of adult subjects were treated once with methyl aminolevulinate (MAL) DL-PDT on one side of the face and MAL c-PDT contralaterally. Endpoints for DL-PDT concerned efficacy (non-inferiority regarding complete lesion response at week 12) and safety (superiority regarding subject's assessment of pain after treatment, on an 11-point numeric rating scale). Safety evaluation also included incidence of adverse events. Subject satisfaction was described using a questionnaire at baseline and last visit. Results At week 12, the total lesion complete response rate with DL-PDT was similar (non-inferior) to c-PDT (70% vs. 74%, respectively; 95% CI [¿9.5; 2.4] in PP analysis, confirmed in ITT analysis). In addition, efficacy of DL-PDT was demonstrated regardless of weather conditions (sunny or cloudy). DL-PDT was nearly painless compared to c-PDT (0.7 vs. 4.4, respectively; P < 0.001), better tolerated and resulted in higher subject satisfaction. Conclusion DL-PDT in comparison with c-PDT was as effective, better tolerated and nearly painless with high patient satisfaction, and may be considered a treatment of choice to meet needs of patients with mild or moderate facial/scalp AKs.
Autores: Ivars, Marta; Redondo, P. ;
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106  Nº 10  2015  págs. 846-48
Autores: Núñez, Jorge María; Aguado-Gil, L; et al.
Revista: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN 0190-9622  Vol. 72  Nº 1  2015  págs. 151 - 158.e1
Background Sturge-Weber syndrome (SWS) is characterized by port-wine stains (PWS) affecting the face, eyes, and central nervous system. Pulsed dye laser (PDL) is the standard treatment for PWS. Unfortunately, recurrence is frequent because of reformation and reperfusion of blood vessels. Objective We sought to assess the clinical efficacy of topical rapamycin combined with PDL in PWS of patients with SWS. Methods We conducted a phase II, randomized, double-blind, intraindividual placebo-controlled, clinical trial. We recruited 23 patients with SWS and facial PWS (12 women; median age 33 years, age range 17-65 years) from the University Clinic of Navarra, Spain. Four interventions were evaluated: placebo, PDL + placebo, rapamycin, and PDL + rapamycin. Clinical and histologic responses were evaluated using a chromatographic computerized system, spectrometry, and histologic analyses at 6, 12, and 18 weeks after the intervention. Results PDL + rapamycin yielded the lowest digital photographic image score and the lowest percentage of vessels in histologic analysis, and showed a statistically significant improvement compared with the other interventions. The treatment was generally well tolerated. Limitations PDL was only applied to the lateral parts of the PWS area. Conclusion Topical rapamycin associated with PDL seems to be an effective treatment for PWS in patients with SWS.
Autores: Redondo, P. ; Cabrera, J; et al.
Revista: WOUND REPAIR AND REGENERATION
ISSN 1067-1927  Vol. 23  2015  págs. 369-378
Venous leg ulcers (VLU) generally have slow healing rates (HR) and frequent recurrence rates (RR). The underlying etiology is venous hypertension. The present observational cohort study was to determine healing and RR in VLU treated with ultrasound-guided foam sclerotherapy (UGFS). One hundred and eighty VLU were treated with polidocanol microfoam monthly under ultrasound control. Median follow-up was 30 months (range: 17-40). One hundred seventy-two (95.6%) ulcers healed during the study. The overall twenty-four week HR was 79.4% and was significantly higher (95.1%) in patients with isolated great saphenous vein incompetence than in those with great saphenous vein plus perforator (91.7%) or exclusive perforator incompetence (78.9%) (p¿<¿0.01). Patients without deep vein incompetence had a significantly higher 6-month HR (89.8%) than those with (67.4%) (p¿<¿0.01). Multivariate analysis identified the following independent risk factors: chronicity¿>¿12 months (OR 7.69), area¿>¿6¿cm(2) (OR 4.24), lipodermatoesclerosis (OR 12.22), history of¿>¿3 previous ulcers (OR 5.57) and history of deep vein thrombosis (OR 6.18). One, two and three year ulcer RR were 8.1%, 14.9%, and 20.8%, respectively. Isolated perforator incompetence and previous history of venous surgery were significantly (p¿=¿0.03) associated with a higher RR. VLU treated with microfoam sclerotherapy are associated with high HR and low mid-term RR.
Autores: De Felipe, I. ; Redondo, P. ;
Revista: JOURNAL OF CUTANEOUS AND AESTHETIC SURGERY
ISSN 0974-2077  Vol. 8  Nº 3  2015  págs. 134 - 138
Context: Hyaluronic acid (HA) is the most common filler used to rejuvenate. Today, a three-dimensional approach prevails over previous techniques in which this material was used in specific areas of the face such as the nasolabial fold, the marionette line, and the eye trough giving a strange appearance that does not look natural. Even with a volumizing purpose, the injection of HA can sometimes produce clinically detectable nodules or lumps where the filler is deposited. Aims: To develop a new technique of injecting HA that can provide more natural results and avoid the lumpiness and nodular appearance that sometimes occurs with the injection of HA. To detect whether mixing HA with diluted anesthetic agent modifies its behavior. Settings and Design: Prospective, case control, single-center study on a private clinic setting. Materials and Methods: Eighty six patients were enrolled in this study. All of them had a previous treatment with nondiluted HA using a needle at least a year before. Patients were injected with 8 mL of reticulated HA (RHA) mixed with 6 mL of saline and 2 mL of anesthetic agent. The mixture was administered through a cannula inserted in the face, one at mid-cheek and another at frontal-temporal point of entry. Owing to the lifting effect of this mixture we called this procedure liquid lift (LL). Patients were evaluated 1 month, 6 months, and a year later and asked to compare the LL with previous experiences in terms of natural look, pain, and appearance of nodules. Statistical Analysis Used: Student's t-test. Results: One month after the treatment, 83 out of 86 patients (96.5%) thought LL produced a more natural look than the previous treatment with the needle. Sixty two (72%) considered LL less painful than the previous treatment and only eight (9.3%) could detect lumps or nodules 1 month after LL was performed compared with 46 (53.5%) that described this problem with previous needle injections. The incidence of bruising was also clearly lower (7% with LL vs 17.4% with traditional needle). Conclusions: Injection of diluted HA with saline and anesthetic agents through a cannula all over the face or LL can provide more natural results and less lumps or nodules, and is less painful than traditional treatments involving needle injection of nondiluted HA.
Autores: Alonso-Alonso, T.; Redondo, P. ; Sanmartín-Jiménez, O.; et al.
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106   Nº 9  2015  págs. 764 - 766
Autores: Núñez, Jorge María; Aguado-Gil, L; et al.
Revista: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN 0190-9622  Vol. 73  Nº 2  2015  págs. e73 - e74
Autores: Hernández-Martín, A.; Dávila-Seijo, P.; De Lucas, R.; et al.
Revista: BRITISH JOURNAL OF DERMATOLOGY
ISSN 0007-0963  Vol. 173  Nº 5  2015  págs. 1280 - 1283
Autores: Redondo, P. ; Núñez, Jorge María; et al.
Revista: JAMA DERMATOLOGY
ISSN 2168-6068  Vol. 151  Nº 8  2015  págs. 897 - 899
Autores: Gilaberte, Y.; Aguilar, M. ; Almagro, M. ; et al.
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 106  Nº 8  2015  págs. 623 - 631
Introducción La terapia fotodinámica con luz de día (TFDLD) es una nueva modalidad de terapia fotodinámica (TFD) que, manteniendo la misma eficacia en queratosis actínicas (QA) grado i y ii que la técnica convencional, disminuye sus efectos adversos y la hace más eficiente. Los condicionantes meteorológicos propios de la España y Portugal hacen necesario el establecimiento de un protocolo adecuado y consensuado por expertos adaptado a los mismos. Objetivo Establecer un protocolo para la TFDLD con metil-aminolevulinato (MAL) para el tratamiento de las QA grado i y ii adecuado y consensuado a las características epidemiológicas, meteorológicas y clínicas que se dan en España y Portugal. Método Doce dermatólogos de diferentes áreas geográficas de ambos países, con experiencia en el tratamiento de las QA con TFD, se reunieron para elaborar un documento de consenso para la realización de TFDLD con MAL. De la revisión de la bibliografía y de su experiencia se elaboró el procedimiento recomendado para su realización. Resultados Las recomendaciones adoptadas establecen que los pacientes con QA grado i y ii múltiples, especialmente en el contexto de campo de cancerización, son los candidatos a realizar este tratamiento. La TFDLD se puede realizar durante todo el año, siendo limitaciones las temperaturas menores de 10 °C o las excesivamente elevadas, así como los días de lluvia, nieve o niebla. El procedimiento es sencillo y requiere la aplicación de un fotoprotector FPS > 30 que solo contenga filtros orgánicos, la preparación adecuada de las lesiones, la aplicación del MAL sin oclusión y su activación con la luz del día durante 2 h. Conclusión Este documento de consenso supone una guía práctica y detallada para la realización de la TFDLD con MAL en España y Portugal destinada a la consecución de la máxima efectividad con mínimos efectos adversos.
Autores: Ferrándiz, C.; Fonseca-Capdevilla, E.; García-Díez, A.; et al.
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 105  Nº 4  2014  págs. 378 - 393
Las características de nuestro entorno sugieren que enfermedades como la queratosis actínica (QA) aumentarán su prevalencia y, en consecuencia, la demanda asistencial en los próximos años. Deben tenerse en cuenta una extensa lista de características clínicas en el abordaje terapéutico de la QA, hasta hace poco compuesto únicamente por técnicas ablativas y exclusivamente dirigidas a las lesiones, sin considerar el campo de cancerización. El incremento del arsenal terapéutico de los últimos años hace necesaria la homogenización de criterios que faciliten la elección de la mejor opción para cada paciente. La formulación de recomendaciones de consenso entre expertos a partir de la revisión de las evidencias científicas en cuanto a diagnóstico y tratamiento disponibles, permite aportar conocimiento dirigido a la mayor calidad en la atención de los pacientes, facilita una mayor homogeneidad en la toma de decisiones y promueve la sensibilización necesaria de todos los agentes sanitarios involucrados.
Autores: Redondo, P. ;
Revista: DERMATOLOGIC SURGERY
ISSN 1076-0512  Vol. 40  Nº 5  2014  págs. 576 - 579
Autores: Redondo, P. ;
Revista: PIEL
ISSN 0213-9251  Vol. 29  Nº Supl. 1  2014  págs. 11 - 13
Autores: Redondo, P. ;
Revista: DERMATOLOGIC SURGERY
ISSN 1076-0512  Vol. 40  Nº 8  2014  págs. 912 - 915
Autores: Redondo, P. ;
Revista: DERMATOLOGIC SURGERY
ISSN 1076-0512  Vol. 40  Nº 1  2014  págs. 69 - 72
Autores: Samaniego, E.; Redondo, P. ;
Título: Lentigo maligno
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 104  Nº 9  2013  págs. 757 - 775
El lentigo maligno (LM) es una variante de melanoma in situ que se desarrolla principalmente en áreas de exposición solar crónica en pacientes de edad media-avanzada. Puede evolucionar a su forma invasiva lentigo maligno melanoma (LMM) en el 5-50% de los casos. Su manejo en ocasiones en controvertido, destacando la ausencia de estudios prospectivos aleatorizados y de guías específicas o protocolos. Es necesario realizar un diagnóstico y tratamiento precoces para obtener la curación, si es posible, y evitar la evolución a melanoma invasivo con el consiguiente riesgo metastásico. El tratamiento de elección del LM es la cirugía. Cuando esta no es posible pueden utilizarse otras alternativas con resultados y tasas de recidiva variables. El objetivo del presente trabajo es realizar una revisión de los métodos y criterios diagnósticos de LM, así como de las diferentes modalidades de tratamiento quirúrgico y las alternativas al mismo, que favorezca el mejor enfoque en cada caso.
Autores: Ríos, L.; Nagore, E; López, J. L.; et al.
Revista: ACTAS DERMO-SIFILIOGRAFICAS
ISSN 0001-7310  Vol. 104  Nº 9  2013  págs. 789 - 799
Background and objectives The Spanish National Cutaneous Melanoma Registry (Registro Nacional de Melanoma Cutáneo [RNMC]) was created in 1997 to record the characteristics of melanoma at diagnosis. In this article, we describe the characteristics of these tumors at diagnosis. Patients and methods This was a cross-sectional observational study of prevalent and incident cases of melanoma for which initial biopsy results were available in the population-based RNMC. Results The RNMC contains information on 14,039 patients. We analyzed the characteristics of 13,628 melanomas diagnosed between 1997 and 2011. In total, 56.5% of the patients studied were women and 43.5% were men. The mean age of the group was 57 years (95% CI, 56.4-57 years) while median age was 58 years. The most common tumor site was the trunk (37.1%), followed by the lower limbs (27.3%). The most frequent clinical-pathologic subtype was superficial spreading melanoma (n=7481, 62.6%), followed by nodular melanoma (n=2014, 16.8%). Localized disease was observed in 86.2% of cases (n=10,382), regional metastasis in 9.9% (n=1188), and distant metastasis in 3.9% (n=479). Independently of age at diagnosis, men had thicker tumors, more ulceration, higher lactate dehydrogenase levels, and a higher rate of metastasis than women (P<.001). Conclusions Based on our findings, melanoma prevention campaigns should primarily target men over 50 years old because they tend to develop thicker tumors and therefore have a worse prognosis.
Autores: Redondo, P. ;
Revista: DERMATOLOGIC SURGERY
ISSN 1076-0512  Vol. 39  Nº 5  2013  págs. 820 - 821
Autores: Redondo, P. ;
Revista: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN 0190-9622  Vol. 67  Nº 5  2012  págs. 991 - 996
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a low-grade malignant skin tumor that may also infiltrate dermis and subcutaneous tissue. Although the mainstay of treatment has been wide local excision, during the last decade three-dimensional (3D) histology surgery has proven very effective for the treatment of this tumor. OBJECTIVE: We sought to evaluate the effectiveness of 3D histology surgery for the treatment of DFSP. METHODS: We retrospectively reviewed charts of patients with DFSP treated in our unit with 3D histology surgery between April 2000 and May 2011. Age at onset, gender, duration of tumor, previous treatment, lesion site, number of surgical stages, postsurgical defect size, closure technique, and follow-up were registered. RESULTS: A total of 29 patients were included. Mean patient age was 40.7 years. Fifteen lesions were located on the trunk, 11 on the extremities, and 3 in the head and neck region. Twelve patients had primary tumors and 17 were referred to us after incomplete excision. The average number of 3D histology surgical stages required for tumor clearance was 1.4. Mean postsurgical defect size was 26 cm(2). All lateral and deep borders excised were tumor-free. Mean follow-up period was 68 months (range 12-142 months) with a 0% recurrence rate. LIMITATIONS: This was a retrospective review. CONCLUSION: Three-dimensional histology surgery with paraffin sections is effective for the treatment of DFSP and feasible in an outpatient setting. The low recurrence rates obtained confirm the oncologic efficacy of the procedure. Furthermore, designing closure on the basis of focally affected margins improves functional and aesthetic outcomes without compromising oncological effectiveness.
Autores: Redondo, P. ;
Revista: ANALES DEL SISTEMA SANITARIO DE NAVARRA
ISSN 1137-6627  Vol. 35  Nº 3  2012  págs. 540 - 543
Autores: Redondo, P. ; Giménez de Azcárate Trívez, A.; Marqués Martín, L.; et al.
Revista: Dermatology Research and Practice
ISSN 1687-6105  Vol. Article ID 532139, 6 pages  2011  págs. 532139-
Patients were followed for up to 6 months using clinical assessment of achromic lesions. Treated areas ranged between 4¿cm(2) and 210.6¿cm(2). Response to treatment was excellent in all patients with 90-95% repigmentation success rate.
Autores: Redondo, P. ; Aguado-Gil, L;
Revista: Journal of the American Academy of Dermatology
ISSN 0190-9622  Vol. 65  Nº 5  2011  págs. 893 - 906
There is significant confusion in the literature when describing vascular anomalies, and vascular malformations are often misnamed or incorrectly classified. Part I of this two-part series on the diagnosis and management of extensive vascular malformation
Autores: Redondo, P. ; Aguado-Gil, L;
Revista: Journal of the American Academy of Dermatology
ISSN 0190-9622  Vol. 65  Nº 5  2011  págs. 909 - 923
At least nine types of vascular malformations with specific clinical and radiologic characteristics must be distinguished in the lower limbs: Klippel¿Trénaunay syndrome, port-wine stain with or without hypertrophy, cutis marmorata telangiectatica congenit
Autores: Aguado-Gil, L; Redondo, P. ;
Revista: PIEL
ISSN 0213-9251  Vol. 26  Nº 6  2011  págs. 285-90
Autores: Redondo, P. ; Aguado-Gil, L;
Revista: ANALES DEL SISTEMA SANITARIO DE NAVARRA
ISSN 1137-6627  Vol. 33  Nº 3  2010  págs. 297 - 308
Las malformaciones venosas representan 2/3 de todas las malformaciones vasculares y con frecuencia son mucho más complejas de lo que realmente parecen. Los pacientes con grandes malformaciones venosas requieren un estudio analítico y radiológico profundo, así como tratamiento específico para controlar una posible coagulación intravascular localizada. Si las lesiones son extensas, especialmente en el miembro inferior, se debe estudiar la presencia de una osteoporosis subyacente con la idea de prevenir fracturas patológicas. Igualmente debe controlarse la artropatía, y valorar la realización de una sinovectomía profiláctica precoz cuando la extensión radiológica lo aconseje, con la idea de evitar daños articulares irreversibles con el paso de los años. Actualmente la escleroterapia con microespuma se preconiza como el tratamiento de elección para las malformaciones vasculares de bajo flujo. En un futuro no muy lejano la utilización de fármacos antiangiogénicos selectivos, además de las heparinas de bajo peso molecular, servirán para controlar y tratar las malformaciones venosas.
Autores: Redondo, P. ;
Revista: Dermatologic Surgery
ISSN 1076-0512  Vol. 36  Nº 1  2010  págs. 123 - 127
Autores: Redondo, P. ; Aguado-Gil, L; et al.
Revista: British Journal of Dermatology (Print)
ISSN 0007-0963  Vol. 162  Nº 2  2010  págs. 350 - 356
Autores: Aguado-Gil, L; Redondo, P. ;
Revista: ARCHIVES OF DERMATOLOGY
ISSN 0003-987X  Vol. 146  Nº 12  2010  págs. 1347 - 1352
: The presence of pulmonary arterial hypertension in patients with extensive slow-flow vascular malformations is not an isolated feature but is relatively frequent. Levels of D-dimer correlate with PASP in these patients.
Autores: Bastarrika, Gorka; Redondo, P. ;
Revista: AMERICAN JOURNAL OF ROENTGENOLOGY
ISSN 0361-803X  Vol. 194  2010  págs. W244-W245
Autores: Redondo, P. ; Aguado-Gil, L; Páramo, José Antonio;
Revista: BRITISH JOURNAL OF DERMATOLOGY
ISSN 0007-0963  Vol. 162  2010  págs. 1156
Autores: Redondo, P. ; Abreu Aguilar, G.;
Libro:  Atlas de otodermias
2012  págs. 177 - 190
Autores: Baselga Torres, E.; López-Gutiérrez, J. C.; Martín-Santiago, A.; et al.
2016 
Autores: Redondo, P. , (Editor); Vázquez, Francisco Javier, (Editor)
2016 
Autores: Redondo, P. , (Editor)
2014 
Autores: Redondo, P. ;
2011 

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