Nuestros investigadores

Santiago Amillo Garayoa

Publicaciones científicas más recientes (desde 2010)

Autores: San-Julian M; Cambeiro, Felix Mauricio; et al.
Revista: RADIOTHERAPY AND ONCOLOGY
ISSN 0167-8140  Vol. 135  2019  págs. 91 - 99
Background: To analyze toxicity, patterns of failure, and survival in 106 adult patients with soft tissue sarcomas of the extremity and the superficial trunk treated in a prospective controlled trial of combined Perioperative High Dose Rate Brachytherapy (PHDRB) and external beam radiotherapy (EBRT). Methods: Patients were treated with surgical resection and 16 Gy or 24 Gy of PHDRB for negative or close/positive margins, respectively. EBRT (45 Gy) was added postoperatively. Adjuvant chemotherapy was given to selected patients with high-grade tumors. Results: The median follow-up was 7.1 years (range, 0.6-16.0). Grade >= 3 adverse events were observed in 22 patients (20.8%), and grade >= 4 events in 14 patients (13.2%). No grade 5 events were noted. Multivariate analysis (p = 0.003) found that Grade >= 3 toxic events increased with increasing implant volume (TV100). Local control, locoregional control, and distant control rates at 5 and 10 years were 89% and 87%, 82% and 80% and 75% and 69%, respectively. Multivariate analysis (p = 0.024) found that positive margins correlated with decreased local control. Disease-free survival and overall survival rates at 5 and 10 years were 64% and 59% and 73% and 62%, respectively. In multivariate analysis, disease-free survival rates decreased with increasing tumor size (p = 0.0001) and inadequate margins (p = 0.024), and overall survival decreased with increasing tumor size (p = 0.001) and male gender (p = 0.039). Conclusions: The combination of conservative surgery, high-dose PHDRB, and EBRT produces adequate function and local control in the majority of patients with soft tissue sarcomas of the extremities and the superficial trunk, including a substantial percentage of cases with positive margins. Patients with larger tumors are at a higher risk of complications, treatment failure, and cancer-related death and require an individualized treatment approach. (C) 2019 Elsevier B.V. All rights reserved.
Autores: Villa, J.; Amillo, Santiago;
Revista: JOURNAL OF HAND AND MICROSURGERY
ISSN 0974-3227  Vol. 9  Nº 1  2017  págs. 47 - 48
Autores: Pons-Villanueva, Juan; Amillo, Santiago;
Revista: MUSCULOSKELETAL SURGERY
ISSN 2035-5106  Vol. 95  Nº 1  2011  págs. 53-7
We report a case of a 15-year-old girl who presented with pain and swelling in the right shoulder. Imaging studies showed an inflammatory process well limited at the rotator interval. Open biopsy showed an osteogenic process that was evident in the postoperative X-rays. Two-year follow-up showed a mature ossification at the rotator interval.
Autores: Amillo, Santiago;
Revista: Revista española de cirugía ortopédica y traumatología (Ed. impresa)
ISSN 1888-4415  Vol. 55  Nº Supl  2011  págs. 121-501
Autores: Amillo, Santiago; Pons-Villanueva, Juan;
Revista: MUSCULOSKELETAL SURGERY
ISSN 2035-5106  Vol. 94  Nº 3  2010  págs. 137-139
cute compartment syndrome of the forearm requires immediate treatment to avoid damage of the soft tissues and a poor functional outcome for the forearm. Muscular and bone lesions are the main causes of acute compartment syndromes. We report a case of acute compartment syndrome of the forearm caused by a calcific tendinitis of the distal biceps.