Revistas
Revista:
ALLERGY
ISSN:
0105-4538
Año:
2023
Vol.:
78
N°:
2
Págs.:
599 - 602
Revista:
INTERNATIONAL JOURNAL OF DERMATOLOGY
ISSN:
0011-9059
Año:
2022
Vol.:
61
N°:
5
Págs.:
600 - 602
Revista:
DERMATOLOGIC SURGERY
ISSN:
1076-0512
Año:
2022
Vol.:
48
N°:
8
Págs.:
867 - 869
Revista:
DERMATOLOGIC THERAPY
ISSN:
1396-0296
Año:
2022
Vol.:
35
N°:
9
Págs.:
e15709
The appearance of morphea after vaccination has been reported to date as single and deep lesions that appear exactly at the site of the skin puncture. It was therefore postulated that the origin could be the trauma related to the injection. The aim of this article is to review the various hypotheses offered in the published literature about generalized morphea following vaccination. We present two cases of generalized morphea after COVID-19 vaccination and review the published literature on immune-related cutaneous reactions. As previously reported, antigenic cross-reactivity between vaccine spike proteins and human tissues could cause certain immune-mediated diseases, including generalized morphea. Herein we report two cases of generalized morphea probably induced by the COVID-19 vaccine, given the temporal relationship with its administration. In summary, environmental factors such as vaccination against SARS-COV-2 could induce an immune system dysregulation, which would have an important role in the pathogenesis of morphea. We present two cases of generalized morphea probably induced by the COVID-19 vaccine, given the time elapsed between vaccination and the onset of the skin lesions.
Revista:
JOURNAL OF ULTRASOUND
ISSN:
1971-3495
Año:
2022
Vol.:
25
N°:
2
Págs.:
289 - 295
Purpose Diagnosis of granuloma annulare (GA) is based on the clinical and histopathological findings. However, only sporadic case reports of subcutaneous GA sonography have been published to date. The objective of this study was to evaluate the ultrasonographic patterns of the different clinical variants of GA: localized, generalized, subcutaneous, and perforating. Methods In this retrospective observational study, we analyzed and correlated the clinical, histopathological, and sonographic features of 15 patients diagnosed with GA. Results We included 8 women and 7 men with a mean age of 48.4 years (8-77 years). We found three different sonographic patterns depending on the clinical variant of GA: poorly defined hypoechoic band including the dermis (dermal pattern), irregularly shaped hypoechoic hypodermal lumps (hypodermal pattern), and ill-defined hypoechoic dermal and subcutaneous lesions (mixed pattern). Five cases showed increased blood flow signal on Doppler interrogation. Conclusion Although our findings are broadly consistent with the previous reports of subcutaneous GA, the sonographic features in localized, generalized, and perforating GA have not been previously reported.
Revista:
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY AND LEPROLOGY
ISSN:
0378-6323
Año:
2022
Vol.:
88
N°:
1
Págs.:
93 - 96
Revista:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE
ISSN:
2213-2198
Año:
2021
Vol.:
9
N°:
6
Págs.:
2284 - 2292
BJECTIVE: In the present work, we sought to verify whether chronic histaminergic angioedema (CHA) is an entity distinct from CSU or represents a CSU subtype that lacks hives.
METHODS: We performed a prospective study comparing 68 CHA patients, angioedema without hives, with 63 CSU patients, with hives and angioedema, from whom we collected demographic and clinical data, as well as blood and serum markers.
RESULTS: We found key pathogenic features that differentiate CHA from CSU: gender distribution, basophil number, and antibodies against the IgE receptor. The male/female ratio in CHA was 0.78, whereas in CSU it was 0.36 (P = .0466). Basopenia was more often seen in CSU (n = 13 [20%]) than in CHA (n = 5 [7%]). Finally, 31.15% of CSU sera induced basophil activation, whereas no CHA sera were able to activate normal basophils. By contrast, nonspecific inflammation or immune markers, for example, erythrocyte sedimentation rate, C-reactive protein, or IgG antithyroid antibodies, were very similar between both groups. IgE antieIL-24 could not be assessed because a control population did not differ from CSU.
CONCLUSIONS: Inclusion of CHA as part of the spectrum of CSU is an assumption not evidence-based, and when studied separately, important differences were observed. Until there is further evidence, CHA and CSU should not necessarily be considered the same disorder, and it is our opinion that review articles and guidelines should reflect that possibility. (C) 2021
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2021
Vol.:
19
N°:
2
Págs.:
265 - 267
Revista:
ACTAS DERMO-SIFILIOGRAFICAS
ISSN:
0001-7310
Año:
2021
Vol.:
112
N°:
10
Págs.:
924 - 925
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2021
Vol.:
19
N°:
4
Págs.:
603 - 604
Revista:
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
ISSN:
0926-9959
Año:
2021
Vol.:
35
N°:
4
Págs.:
988 - 994
Background Confusion exists regarding interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic and granulomatous dermatitis (PNGD). Objective To determine whether IGD and PNGD are two different entities, or whether they must be considered as two subtypes of the same reactive pattern, and thus whether the unification of the nomenclature is necessary. Methods Observational retrospective multicentre study of patients with IGD and PNGD evaluated between 1999 and 2019 and review of their clinical and histological features. Results We identified 52 patients (38 women and 14 men). Clinical and histological findings of IGD were observed in 88.4% of cases. The most common cutaneous lesions were plaques/macules (IGD) or annular plaques and papules/nodules (PNGD), located mostly on the limbs and trunk. The rope sign was developed in two patients with IGD that associated autoimmune disorders. Similar associated comorbidities (75%) were found in both entities, mainly autoimmune diseases (53.8%). In IGD, the infiltrate was predominantly lympho-histiocytic. Neutrophilic infiltrates, karyorrhexis and skin lesions with limited clinical course were mainly associated with PNGD biopsies. In biopsies with a limited recurrent course, a predominant lymphocytic inflammatory infiltrate was found. Collagen degeneration was present in 75.9% of cases. The floating sign was observed only in IGD type patients (63%). Overlapping histological findings were found in one fourth of cases, especia
Revista:
PEDIATRIC DERMATOLOGY
ISSN:
0736-8046
Año:
2020
Vol.:
37
Págs.:
750 - 751
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2020
Vol.:
18
N°:
10
Págs.:
1192 - 1196
Revista:
MEDICINA CLINICA
ISSN:
0025-7753
Año:
2020
Vol.:
155
N°:
1
Págs.:
26 - 29
Introduction: Parvovirus B19 (PVB19) infection has a high incidence and worldwide distribution. It has a broad clinical spectrum, with skin, joint and haematological manifestations being the most common. The objective of this study was to determine the epidemiology and clinical-analytical manifestations of acute PVB19 infection. Patients and methods: A retrospective study of patients with a positive IgM serology for PVB19 (10 years). Forty-six patients were included and their demographic, clinical and analytical characteristics were analyzed. Results: Primary infection was most prevalent in women (ratio 2.2:1) aged 41 (mean age). Joint involvement was the most common manifestation (65%). Skin abnormalities were observed in more than half of patients (24 cases): rash (28%), megalerythema (9%), "gloves and socks" involvement (6.5%), periflexural rash (4%) and oedema (4%). Anaemia was the main haematological alteration (35%). The symptoms were self-limiting and resolved in 1-2 weeks in most patients. Conclusions: Although there is a variable clinical spectrum, polyarthralgias and generalized maculopapular rash with fever and anaemia are the typical and most frequent manifestations of primary infection by PVB19 and are usually self-limiting.
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2020
Vol.:
18
N°:
9
Págs.:
1028 - 1030
Revista:
DERMATOLOGIC THERAPY
ISSN:
1529-8019
Revista:
PIEL
ISSN:
0213-9251
Año:
2019
Vol.:
34
N°:
3
Págs.:
175-179
Revista:
PIEL
ISSN:
0213-9251
Año:
2019
Vol.:
34
N°:
3
Págs.:
175 - 179
Revista:
PEDIATRIC DERMATOLOGY
ISSN:
0736-8046
Revista:
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
ISSN:
1610-0379
Año:
2018
Vol.:
16
N°:
6
Págs.:
763 - 768
Revista:
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN:
0190-9622
Año:
2018
Vol.:
7
Págs.:
633 - 635
Revista:
ANNALS OF HEMATOLOGY
ISSN:
0939-5555
Año:
2018
Vol.:
97
N°:
3
Págs.:
543 - 544
Nacionales y Regionales
Título:
Análisis de la expresión génica de los basófilos y del proteoma sérico en pacientes con urticaria crónica y/o angioedema histaminérgico.
Código de expediente:
PI20/01536
Investigador principal:
Marta Ferrer Puga
Financiador:
INSTITUTO DE SALUD CARLOS III
Convocatoria:
2020 AES Proyectos de investigación
Fecha de inicio:
01/01/2021
Fecha fin:
31/12/2023
Importe concedido:
135.520,00€
Otros fondos:
Fondos FEDER