Nuestros investigadores

José Ramón Azanza Perea

Publicaciones científicas más recientes (desde 2010)

Autores: Azanza, José Ramón; Sadaba, María Belén;
ISSN 0214-3429  Vol. 32  Nº Suppl. 3  2019  págs. 11 - 16
Ceftobiprole shows many similar pharmacokinetic properties to other cephalosporins, except for not being orally bioactive, and that it is administered by IV infusion as the prodrug ceftobiprole medocaril, which is subsequently hydrolyzed in the blood into the active molecule. Distribution focus in extracellular fluid and active antibiotic concentration has been proven in different corporal tissues using dosing regimen of 500 mg intravenous infusion over 2 h every 8 h. Ceftobiprole is eliminated exclusively into the urine, thus the reason why dose adjustment is required for patients with moderate or severe renal impairment, or increased creatinine clearance. However, there is no need for dose adjustments related with other comorbidities and patients' conditions such as age, body weight. Although considering distribution features, molecular weight and dose fraction, increase dosing regimen might be necessary in patients using renal replacement therapy. The half-life of ceftobiprole is more than 3 h, allowing to easily reach optimal PK/PD parameters with the infusion time of 2 h, using the usual dosing
Autores: Azanza, José Ramón;
ISSN 0214-3429  Vol. 32  Nº Supl. 2  2019  págs. 35 - 37
In the past, the dose of an antibiotic was chosen, always from among those that were well tolerated, by considering those with the ability to exceed the MIC of bacteria in plasma. This approach, which has still not widely changed, is contrasted with the pharmacokinetic and pharmacodynamic (PK/PD) relationships, which indicate that the efficacy of antibiotics is directly related to parameters that relate the sequence of concentrations over time with a parameter of the MIC effect in vitro. Until now, three types of PK/PD relationships have been established for antibiotics: the inhibitory coefficient (Cmax/MIC), the efficacy time (T>CMI) and the relationship between the exposure of the drug and the MIC (AUC/MIC)
Autores: Pérez Civantos DV, (Autor de correspondencia); Robles Marcos M; Azanza, José Ramón; et al.
ISSN 1201-9712  Vol. 86  2019  págs. 142 - 146
OBJECTIVE: To describe the pharmacokinetic (PK) profile of anidulafungin and to evaluate its concentration in the peritoneal fluid (PF) of patients suspected of suffering from peritoneal infection undergoing abdominal surgery, in order to ensure that therapeutic levels are achieved within the peritoneal cavity. METHODS: A descriptive, open, prospective, observational, multicentre and non-interventional study was performed. Anidulafungin was used at conventional doses. Blood and PF samples were obtained on day 2 of treatment or on any of the following days. RESULTS: A total of 31 patients in a serious clinical condition, as demonstrated by high mean clinical severity scale scores (APACHE II and SOFA scores), were included in the study. The mean area under the curve (AUC) in PF was 30% (31±19%) of that determined in the plasma and the maximum concentration (Cmax) reached in PF (mg/l) was close to 1 (0.9±0.5). No adverse effects were observed in any of the 31 patients. CONCLUSIONS: Anidulafungin at conventional doses reaches PF concentrations that exceed the minimum inhibitory concentration of the usual Candida spp, which explains the proven efficacy of this echinocandin in the treatment of Candida peritonitis in critically ill patients.
Autores: Azanza, José Ramón; Ibeas, J.; et al.
ISSN 0211-6995  Vol. 39  Nº 1  2018  págs. 1 - 2
En el artículo «Guía Clínica Española del Acceso Vascular para Hemodiálisis» (Nefrologia. 2017;37[Supl 1]:1-192) se ha detectado un error en la filiación de la Dra. Isabel Crehuet, siendo la correcta: Hospital Universitario Río Hortega, Valladolid
Autores: Azanza, José Ramón, (Autor de correspondencia); Sadaba, María Belén;
ISSN 1130-1406  Vol. 35  Nº 4  2018  págs. 186 - 191
Isavuconazole is a new azole, structurally related to fluconazole and voriconazole, that presents a very high oral absorption with no first-pass effect which is not interfered by the presence of food, gastric pH modifications, or mucositis. Its distribution volume is very high, probably also to cerebrospinal fluid, in spite of the fact that it circulates highly bound to plasma proteins. It is extensively metabolized through the CYP3A4 isoenzyme. Due to this reason, it is recommended to avoid co-administration with strong CYP3A4 inducers. In addition, isavuconazole may inhibit CYP3A4. Moreover, it may induce CYP2B6 and Pglycoprotein. Interestingly, this inhibitory activity seems to be lower compared to other azoles. Therefore, the management of any interaction with other medicines is easier, which is probably the most important advantage of this antifungal. (C) 2018 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.
Autores: Azanza, José Ramón, (Autor de correspondencia); Sadaba, María Belén; Diez N;
ISSN 2456-3501  Vol. 3  2018 
Autores: Mensa, J., (Autor de correspondencia); Barberan, J.; Soriano, A.; et al.
ISSN 0214-3429  Vol. 31  Nº 1  2018  págs. 78 - 100
Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics, mainly mediated by the expression of inducible chromosomic beta-lactamases and the production of constitutive or inducible efflux pumps. Apart from this intrinsic resistance, P. aeruginosa possess an extraordinary ability to develop resistance to nearly all available antimicrobials through selection of mutations. The progressive increase in resistance rates in P. aeruginosa has led to the emergence of strains which, based on their degree of resistance to common antibiotics, have been defined as multidrug resistant, extended-resistant and panresistant strains. These strains are increasingly disseminated worldwide, progressively complicating the treatment of P. aeruginosa infections. In this scenario, the objective of the present guidelines was to review and update published evidence for the treatment of patients with acute, invasive and severe infections caused by P. aeruginosa. To this end, mechanisms of intrinsic resistance, factors favoring development of resistance during antibiotic exposure, prevalence of resistance in Spain, classical and recently appeared new antibiotics active against P. aeruginosa, pharmacodynamic principles predicting efficacy, clinical experience with monotherapy and combination therapy, and principles for antibiotic treatment were reviewed to elaborate recommendations by the panel of experts for empirical and directed treatment of P. aeruginosa invasive infections.
Autores: Sadaba, María Belén, (Autor de correspondencia); Gómez-Guiu, María de la Almudena; Roset Arissó PN; et al.
ISSN 1134-8046  Vol. 25  Nº 4  2018  págs. 222-227
Autores: Azanza, José Ramón; Sadaba, María Belén; Reis de Carvalho, Joana Sofía;
ISSN 0213-005X  Vol. 35  Nº Suppl 1  2017  págs. 22 - 27
Dalbavancin is a new lipoglycopeptide antibiotic whose structure influences its pharmacokinetic profile. It is not absorbed after oral administration and is therefore administered intravenously. It is distributed through intracellular fluid, reaching adequate concentrations in the skin, bone, blister fluid and synovial fluid. Plasma protein binding is very high. Concentrations in brain tissue and cerebrospinal fluid (CSF) are inadequate. Excretion is through non-microsomal metabolism with inactive metabolites and through the kidneys by glomerular filtration. Dalbavancin is eliminated slowly, as shown by its clearance value and its terminal elimination half-life, which exceeds 300 hours. This means that adequate concentrations of the drug remain in plasma and tissues for a prolonged period and explains the dosing regimen: a first dose of 1g followed 7 days later by a 500mg dose. The pharmacokinetics are linear and show little intra- and interindividual variability. There are no pharmacokinetic interactions. Dose adjustment is not required for patients with mild or moderate renal insufficiency (creatinine clearance &#8805; 30 to 79ml/min). Dosage adjustment is not required in patients regularly receiving elective haemodialysis (3 times/week) and the drug can be administered without consideration of haemodialysis times. In patients with chronic renal insufficiency, whose creatinine clearance is < 30ml/min and who are not regularly receiving elective haemodialysis,
Autores: Grau, S.; Azanza, José Ramón; Ruiz, I.; et al.
ISSN 1178-6981  Vol. 9  2017  págs. 39 - 47
OBJECTIVE: According to a recent randomized, double-blind clinical trial comparing the combination of voriconazole and anidulafungin (VOR+ANI) with VOR monotherapy for invasive aspergillosis (IA) in patients with hematologic disease or with hematopoietic stem cell transplant, mortality was lower after 6 weeks with VOR+ANI than with VOR monotherapy in a post hoc analysis of patients with galactomannan-based IA. The objective of this study was to compare the cost-effectiveness of VOR+ANI with VOR, from the perspective of hospitals in the Spanish National Health System. METHODS: An economic model with deterministic and probabilistic analyses was used to determine costs per life-year gained (LYG) for VOR+ANI versus VOR in patients with galactomannan-based IA. Mortality, adverse event rates, and life expectancy were obtained from clinical trial data. The costs (in 2015 euros [€]) of the drugs and the adverse event-related costs were obtained from Spanish sources. A Tornado plot and a Monte Carlo simulation (1,000 iterations) were used to assess uncertainty of all model variables. RESULTS: According to the deterministic analysis, for each patient treated with VOR+ANI compared with VOR monotherapy, there would be a total of 0.348 LYG (2.529 vs 2.181 years, respectively) at an incremental cost of €5,493 (€17,902 vs €12,409, respectively). Consequently, the additional cost per LYG with VOR+ANI compared with VOR would be €15,785. Deterministic sensitivity analyses confirmed the robustness of these findings. In the probabilistic analysis, the cost per LYG with VOR+ANI was €15,774 (95% confidence interval: €15,763-16,692). The probability of VOR+ANI being cost-effective compared with VOR was estimated at 82.5% and 91.9%, based on local cost-effectiveness thresholds of €30,000 and €45,000, respectively. CONCLUSION: According to the present economic study, combination therapy with VOR+ANI is cost-effective as primary therapy of IA in galactomannan-positive patients in Spain who have hematologic disease or hematopoietic stem cell transplant, compared with VOR monotherapy.
Autores: Gutiérrez-Rojas, L.; Pulido, S.; Azanza, José Ramón; et al.
ISSN 1139-9287  Vol. 44  Nº 1  2016  págs. 20 - 29
BACKGROUND: Metabolic syndrome (MS) and cardiovascular risk factors (CRF) have been associated with patients with schizophrenia. The main objective is to assess the evolution of CRF and prevalence of MS for 12 months in a cohort of overweight patients diagnosed with schizophrenia schizophreniform disorder or schizoaffective disorder in which the recommendations for the assessment and control of metabolic and cardiovascular risk were applied. METHODS: The Control of Metabolic and Cardiovascular Risk in Patients with Schizophrenia and Overweight (CRESSOB) study is a 12-month, observational, prospective, open-label, multicentre, naturalistic study including 109 community mental health clinics of Spain. The study included a total of 403 patients, of whom we could collect all variables related to CRF and MS in 366 patients. Of these 366 patients, 286 completed the follow-up, (baseline, months 3, 6 and 12) where they underwent a complete physical examination and a blood test (glucose, cholesterol and triglycerides), they were asked about their health-related habits (smoking, diet and exercise) and they were given a series of recommendations to prevent cardiovascular risk and MS. RESULTS: A total of 403 patients were included, 63% men, mean age (mean; (SD)) 40.5 (10.5) years. After 12 months, the study showed statistically significant decrease in weight (p<0.0001), waist circumference (p<0.0001), BMI (p<0.0001), blood glucose (p=0.0034), total cholesterol (p<0.0001), HDL cholesterol (p=0.02), LDL cholesterol (p=0.0023) and triglycerides (p=0.0005). There was a significant reduction in the percentage of smokers (p=0.0057) and in the risk of heart disease at 10 years (p=0.0353). CONCLUSION: Overweight patients with schizophrenia who receive appropriate medical care, including CRF monitoring and control of health-related habits experience improvements with regard to most CRFs.
Autores: Azanza, José Ramón; López-Jiménez, J.; Parody-Porras, R.; et al.
ISSN 0214-3429  Vol. 29  Nº 1  2016  págs. 15 - 24
Introducción. Las complicaciones infecciosas son una causa importante de morbi-mortalidad en los pacientes hematológicos con neutropenia febril. El objetivo del presente trabajo fue desarrollar un documento de recomendaciones consensuado para optimizar el manejo del paciente hematológico con neutropenia febril o infecciones por catéteres vasculares en áreas en las que no se dispone de una sólida evidencia científica. Material y métodos. Tras la revisión de las evidencias científico-médicas, un comité científico formado por especialistas expertos en hematología y enfermedades infecciosas elaboró una encuesta con 55 aseveraciones. Para el consenso se utilizó un método Delphi modificado con dos rondas de evaluación. Resultados. La encuesta fue respondida online por 52 especialistas en hematología y en enfermedades infecciosas. Tras las dos rondas de evaluación fue posible el consenso en 43 de los 55 ítems planteados (un 78,2%): 40 en el acuerdo y 3 en el desacuerdo. Con ello, se proporcionan una serie de recomendaciones relativas al tratamiento antibiótico empírico del paciente con neutropenia febril, a cuestiones relacionadas con mecanismos de acción, toxicidad y sinergia de los antibióticos en este contexto, a las modificaciones del tratamiento antibiótico en el curso de la neutropenia febril y al manejo de las infecciones de catéter vascular central en el ámbito hematológico. Conclusiones. Existe un alto grado de acuerdo entre los expertos consultados sobre algunos aspectos controvertidos relativos al manejo de la neutropenia febril y la infección por catéter en pacientes hematológicos. Este acuerdo se ha traducido en unas recomendaciones que pueden ser de utilidad en la práctica clínica.
Autores: Azanza, José Ramón; Sadaba, María Belén; Gómez-Guiu, María de la Almudena;
ISSN 1078-1552  Vol. 21  Nº 5  2015  págs. 370 - 376
Complete monoclonal IgG antibodies which are in use in clinical practice share some pharmacological properties resulting in high concentrations in plasma. This fact is reflected in their low volumes of distribution, which can also be correlated with a high molecular weight and water solubility. This feature allows a novel approach to be applied to the dosing schedule for this group of drugs with fixed doses being used instead of the initially developed weight- or body surface-adjusted dosing schedules. In addition, the development of a new formulation containing hyaluronidase allows a subcutaneous route of administration to be used, because hyaluronidase creates a space in the subcutaneous tissue that helps antibody absorption. This method requires higher doses, but has allowed testing the feasibility of administering a fixed dose, with no individual dose adjustments based on weight or body surface. Moreover, loading doses are not needed, because the first dose results, within 3 weeks, in minimum concentrations that are higher than effective concentrations.
Autores: Azanza, José Ramón; Sadaba, María Belén; Reis de Carvalho, Joana Sofía;
ISSN 0214-3429  Vol. 28  Nº 6  2015  págs. 275 - 281
This article presents an overview of the characteristics of liposomes as drug carriers, particularly in relation to liposomal formulations of amphotericin B. General features regarding structure, liposome-cell interactions, stability, encapsulation of active substances and elimination of liposomes are described. Up to the present time extensive efforts to produce similar or bioequivalent products of amphotericin B formulations, in particular in the case of liposomal amphotericin B, have been unsuccessful in spite of having a very similar composition and even an apparently identical manufacturing process. Guidelines for the development of generic liposomal formulations developed by the FDA and EMA are also summarized. Based on the available evidence of the composition of liposomes, any differences in the manufacturing process even if the same lipid composition is used may result in different final products. Therefore, it seems unreasonable to infer that all amphotericin B liposomal formulations are equal in efficacy and safety.
Autores: del Pozo, José Luis; Azanza, José Ramón; et al.
ISSN 0269-4727  Vol. 40  Nº 5  2015  págs. 601 - 603
What is known and objectiveInvasive fungal infections are a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). This provides a clear rationale for antifungal prophylaxis in this population. A concern is the potential for drug interactions, given that most of antifungals are metabolized through the P450 cytochrome system. Case summaryWe present a case of a 33-year-old woman, with a past history of high-risk epilepsy, who underwent allogeneic HSCT for a myelodysplastic syndrome. Anidulafungin was successfully used as antifungal prophylaxis to minimize drug interactions with her antiepileptic treatment. What is new and conclusionThis is the first reported case of antifungal prophylaxis with this echinocandin in HSCT. Anidulafungin may be an option in transplant recipients with multiple risk factors for drug interactions.
Autores: Azanza, José Ramón; Sadaba, María Belén;
ISSN 0365-6691  Vol. 90  Nº Supl. 1  2015  págs. 6 - 10
Aflibercept es una proteina de fusion que combina en su estructura quimica, la fraccion constante de cualquier IgG con una fraccion variable construida con partes fundamentales de los receptores del factor de crecimiento del endotelio vascular, por ello es capaz de fijar a diversas isoformas del factor de crecimiento del endotelio vascular y tambien al factor de crecimiento placentario, lo que se ha puesto en relacion con un posible efecto sinergico en la eficacia. La afinidad es mayor que la que presentan ranibizumab y bevacizumab. Ademas produce un efecto antiinflamatorio intraocular. La administracion por via intravitrea cursa con la presencia de trazos del farmaco en el plasma del paciente; de hecho, las concentraciones son tan reducidas que la presencia de efectos adversos sistemicos, incluida la hipertension arterial, es practicamente nula. Una semivida de eliminacion intraocular prolongada unida a la afinidad elevada supone que sea posible la utilizacion en pautas posologicas comodas, ya que tras una inyeccion mensual para las 3 primeras dosis se aumenta el intervalo a una inyeccion cada 2 meses, que tras los primeros 12 meses puede vincularse a los resultados visuales y anatomicos.
Autores: Azanza, José Ramón; Sadaba, María Belén; Gómez-Guiu, María de la Almudena;
ISSN 1130-1406  Vol. 31  Nº 4  2014  págs. 255 - 261
El tratamiento de la aspergilosis invasora exige la utilización de algunos fármacos que de forma característica presentan propiedades farmacocinéticas complejas, cuyo conocimiento es imprescindible para alcanzar la máxima eficacia con el mínimo riesgo para el paciente. Las formulaciones lipídicas de anfotericina B son muy distintas en su comportamiento farmacocinético, con concentraciones plasmáticas de la forma liposómica muy elevadas en probable relación con la presencia de colesterol en su estructura. Los azoles presentan un perfil de absorción variable, especialmente en el caso del itraconazol y del posaconazol, este último muy dependiente de múltiples factores. En el caso del voriconazol puede existir variabilidad a este respecto, lo que obliga a considerar la posibilidad de realizar una monitorización de las concentraciones plasmáticas. El objetivo de este artículo es revisar algunos de los aspectos más relevantes de la farmacología de los antifúngicos utilizados en la profilaxis y el tratamiento de la infección aspergilar. Por ello se incluirán los aspectos más relevantes de algunos de los azoles que suelen prescribirse en esta infección (itraconazol, posaconazol y voriconazol) y de las formulaciones de anfotericina B.
Autores: Sadaba, María Belén; Campanero, MA; et al.
Revista: PLOS ONE
ISSN 1932-6203  Vol. 9  Nº 2  2014  págs. e89747
Palonosetron is a potent second generation 5- hydroxytryptamine-3 selective antagonist which can be administered by either intravenous (IV) or oral routes, but subcutaneous (SC) administration of palonosetron has never been studied, even though it could have useful clinical applications. In this study, we evaluate the bioavailability of SC palonosetron. PATIENTS AND METHODS: Patients treated with platinum-based chemotherapy were randomized to receive SC or IV palonosetron, followed by the alternative route in a crossover manner, during the first two cycles of chemotherapy. Blood samples were collected at baseline and 10, 15, 30, 45, 60, 90 minutes and 2, 3, 4, 6, 8, 12 and 24 h after palonosetron administration. Urine was collected during 12 hours following palonosetron. We compared pharmacokinetic parameters including AUC0-24h, t1/2, and Cmax observed with each route of administration by analysis of variance (ANOVA). RESULTS: From October 2009 to July 2010, 25 evaluable patients were included. AUC0-24h for IV and SC palonosetron were respectively 14.1 and 12.7 ng × h/ml (p¿=¿0.160). Bioavalability of SC palonosetron was 118% (95% IC: 69-168). Cmax was lower with SC than with IV route and was reached 15 minutes following SC administration. CONCLUSIONS: Palonosetron bioavailability was similar when administered by either SC or IV route. This new route of administration might be specially useful for outpatient management of emesis and for administration of oral chemotherapy.
Autores: Gutiérrez-Rojas L; Azanza, José Ramón; Bernardo M.; et al.
ISSN 1139-9287  Vol. 42  Nº 1  2014  págs. 9-17
MS is highly prevalent in Spanish patients with schizophrenia who are overweight. Given that metabolic syndrome is an important risk factor for cardiovascular disease, these patients should receive appropriate clinical monitoring for this syndrome.
Autores: Len, O.; Montejo, M.; Cervera, C.; et al.
ISSN 1398-2273  Vol. 16  Nº 4  2014  págs. 532 - 538
Introduction Infections caused by resistant gram-positive cocci (GPC), especially to glycopeptides, are difficult to treat in solid organ transplant (SOT) recipients as a result of lower effectiveness and high rates of renal impairment. The aim of this study was to evaluate the use of daptomycin in this population. Methods Over a 2-year period (March 2008-2010) in 9 Spanish centers, we enrolled all consecutive recipients who received daptomycin to treat GPC infection. The study included 43 patients, mainly liver and kidney transplant recipients. Results The most frequent infections were catheter-related bacteremia caused by coagulase-negative staphylococci (23.2%), skin infection caused by Staphylococcus aureus (11.5%), and intra-abdominal abscess caused by Enterococcus faecium (20.9%). The daily daptomycin dose was 6mg/kg in 32 patients (74.4%). On day 7 of daptomycin treatment, median estimated area under the curve was 1251g/mL/h. At the end of follow-up, analytical parameters were similar to the values at the start of therapy. No changes were observed in tacrolimus levels. No patient required discontinuation of daptomycin because of adverse effects. Clinical success at treatment completion was achieved in 37 (86%) patients. Three patients died while on treatment with daptomycin. Conclusion In summary, daptomycin was a safe and useful treatment for GPC infection in SOT recipients.
Autores: Aguilar G; Azanza, José Ramón; Carbonell JA; et al.
ISSN 0305-7453  Vol. 69  Nº 6  2014  págs. 1620-23
The influence of CRRT on anidulafungin elimination appeared to be negligible. Therefore, we recommend no adjustments to the anidulafungin dose for patients receiving CRRT.
Autores: Giménez, E.; Solano, C.; Azanza, José Ramón; et al.
ISSN 0066-4804  Vol. 58  Nº 9  2014  págs. 5602 - 5605
It is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients. In this observational study, including 13 episodes of CMV DNAemia treated with intravenous (i.v.) GCV or oral valganciclovir, we showed that monitoring trough plasma GCV levels does not reliably predict response to therapy. Rather, immunological monitoring (pp65 and immediate-early [IE]-1-specific gamma interferon [IFN-gamma]-producing CD8(+) T cells) appeared to perform better for this purpose.
Autores: Aguilar, G.; Azanza, José Ramón; Sadaba, María Belén; et al.
ISSN 1574-4280  Vol. 18  Nº 2  2014  págs. 422
Autores: Mensa J.; Soriano A.; Llinares P.; et al.
ISSN 0214-3429  Vol. 26  Nº Supl. 1  2013  págs. 1-84
Autores: Sadaba, María Belén; Gómez-Guiu, María de la Almudena; Azanza, José Ramón; et al.
ISSN 1173-2563  Vol. 33  Nº 5  2013  págs. 375-381
The absorption of bilastine after oral administration to healthy subjects was rapid. The absolute oral bioavailability was moderate
Autores: Parra, María Asunción; Campanero, MA; Sadaba, María Belén; et al.
ISSN 0896-8608  Vol. 33  Nº 4  2013  págs. 458-461
Autores: Sadaba, María Belén; Azanza, José Ramón; Gómez-Guiu, María de la Almudena; et al.
ISSN 1176-6336  Vol. 9  2013  págs. 197-205
Bilastine is a second generation antihistamine indicated for the treatment of seasonal or perennial allergic rhinoconjunctivitis and chronic urticaria with a daily dose of 20 mg, in adults and children over 12 years of age. The efficacy of bilastine has been shown to be similar to that of the comparator drugs for the control of the nasal and nonnasal symptoms of allergic rhinoconjunctivitis, while also showing a subjective improvement in the quality of life and in overall clinical impression. For chronic urticaria the symptoms (itching and the development of papules) lessens from the second day of treatment onwards, in a similar way to other antihistamines used as comparators. Bilastine should not be administered at meal times to avoid interference with the absorption process. It is not distributed to the central nervous system, is scarcely metabolized, and elimination is through the kidneys and feces, with a 14-hour elimination half-life. It has no effect on cytochrome P450. During clinical development, bilastine was shown to be a drug that is adequately tolerated, with a similar effect to placebo with regard to drowsiness and changes in heart rate. In relation to its use, headaches were the most frequent adverse effect to be reported. No cardiotoxic effects have been observed, and the therapeutic dose does not alter the state of alertness
Autores: Heras M.; Parra, María Asunción; Macías MC; et al.
ISSN 0211-6995  Vol. 33  Nº 2  2013  págs. 273-75
Autores: Azanza, José Ramón; J. Barberán;
ISSN 0214-3429  Vol. 25  Nº 1  2012  págs. 17 - 24
Amphotericin B in its lipid formulation continues to be the reference drug in the treatment of systemic fungal infections despite the time elapse since the development of this compound. The absence of fungal resistance, pharmacokinetics, and the better tolerability profile as compared with the remaining formulations of amphotericin B are sufficient reasons to justify its prominent therapeutic role. The liposome containing liposomal amphotericin B is very stable in relation to the presence of cholesterol and phospholipids are not thermolabile, so that free amphotericin B is almost inexistent (<1%), which explains the reduced incidence of effects related to the drug administration, and a reduction in the incidence of nephrotoxicity (half than that with amphotericin B lipid complex) and that even in some studies at doses of 1 mg/kg has been shown to be negligible. This profile explains the very high plasma drug concentrations and the reduced distribution volume and clearance, with a very prolonged elimination half-life. There are evidences showing that the liposome through amphotericin B is capable of binding to ergosterol present in the fungal membrane and only at this moment would be the antifungal released to exert its pharmacological effects.
Autores: Azanza, José Ramón; García, Alfredo;
ISSN 0365-6691  Vol. 87  Nº Suppl. 1  2012  págs. 3 - 9
Autores: Sadaba, María Belén; Azanza, José Ramón; Gómez-Guiu, María de la Almudena;
ISSN 1699-3993  Vol. 47  Nº 4  2011  págs. 251-262
Bilastine is a potent inhibitor of the histamine H1 receptor. It was recently approved in 28 countries of the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria in adults and children older than 12 years. Data from preclinical studies confirmed its selectivity for the histamine H1 receptor over other receptors, and demonstrated antihistaminic and antiallergic properties in vivo. Studies in healthy volunteers and patients have shown that bilastine does not affect driving ability, cardiac conduction or alertness. Bilastine has demonstrated a good safety profile, without serious adverse effects or antimuscarinic effects in clinical trials. There were no significant changes in laboratory tests, electrocardiograms or vital signs. In clinical studies, oral treatment with bilastine 20 mg once daily improved allergic rhinitis with greater efficacy than placebo and comparable to cetirizine and desloratadine. Bilastine 20 mg was more effective than placebo and equivalent to levocetirizine in chronic urticaria, relieving symptoms, improving quality of life and controlling sleep disorders.
Autores: Carreras E.; Vázquez L.; Rodríguez Tudela JL; et al.
ISSN 0213-005X  Vol. 29  Nº Supl. 4  2011  págs. 42 - 47
Autores: Candel, F.J.; Martínez-Sagasti, F.; Borges M., M.; et al.
Revista: Revista Espanola de Quimioterapia
ISSN 0214-3429  Vol. 23  Nº 3  2010  págs. 115 - 121
Autores: García, Emilio; Urdaneta Abate, M.M.; Sadaba, María Belén; et al.
Revista: Revista de Osteoporosis y Metabolismo Mineral
ISSN 1889-836X  Vol. 2  Nº 2  2010  págs. 35 - 46
Autores: Azanza, José Ramón; García, Emilio;
ISSN 0025-7753  Vol. 135  Nº Supl. 3  2010  págs. 55-59
Daptomycin is a lipopeptide bactericidal antimicrobial indicated in the treatment of skin and soft tissue infections (SSTI), Staphylococcus aureus-related right-sided infective endocarditis (RIE) and bacteremia secondary to these infections. The recommended dosage in patients with previous renal impairment is 4 mg/kg/48 hours in SSTI. There are no data published for SSTI and RIE followed by bacteremia. Based on pharmacokinetic models, the recommended dosage in patients under hemodialysis is 4 mg/kg after dialysis. The present article aims to review of the latest published data on daptomycin use in patients with renal impairment and to relate these findings to preliminary data from the EUCORE registry in Spain.
Autores: Campanero, MA; et al.
Revista: Journal of Pharmaceutical and Biomedical Analysis
ISSN 0731-7085  Vol. 51  Nº 4  2010  págs. 875 - 881
Autores: Azanza, José Ramón; et al.
ISSN 0214-3429  Vol. 23  Nº Supl.1  2010  págs. 18-24
Autores: del Pozo, José Luis; Van de Beek, D.; Mandrekar, J. N.; et al.
ISSN 1058-4838  Vol. 50  Nº 1  2010  págs. 121 - 122
Autores: Alós Cortés, J. I.; Anglada Martínez, H.; Alonso Pérez, D.; et al.
Libro:  Guía de terapéutica antimicrobiana 2016
2016  págs. 2 - 231
Autores: Mediavilla, A.; Flórez, J.; Azanza, José Ramón; et al.
Libro:  Farmacología humana
2014  págs. 1027-1043
Autores: Alos JI; Anglada H; Alonso D; et al.
Libro:  Guía de Terapéutica Antimicrobiana 2013
2013  págs. 1-217
Autores: Azanza, José Ramón; García, Emilio; et al.
Libro:  Farmacología en Enfermería
2012  págs. 599-614
Autores: Azanza, José Ramón; Sadaba, María Belén; Gómez-Guiu, María de la Almudena; et al.
Libro:  Dolor neuropático en el enfermo oncológico. Manual práctico con casos clínicos
2012  págs. 18-42
Autores: Alos JI; Alonso D; Azanza, José Ramón; et al.
Libro:  Guía de Terapéutica Antimicrobiana 2012
2012  págs. 1-212
Autores: Azanza, José Ramón; García, Emilio;
Libro:  Farmacología en Enfermería
2012  págs. 585 - 598
Autores: Azanza, José Ramón; García, Emilio; Gómez-Guiu, María de la Almudena; et al.
Libro:  Infección fúngica en el trasplante de órganos sólidos
2011  págs. 149-166
La infección fúngica invasora (IFI) en el trasplante de órgano sólido (TOS) se asocia a una importante mortalidad (30-100%) debido a la dificultad que existe para hacer un diagnóstico precoz en estos pacientes y a los relativamente escasos recursos terapéuticos con los que todavía contamos. En los últimos años se han producido múltiples avances en diferentes aspectos de la IFI en la TOS que han sido recogidos detalladamente en esta monografía de la colección "Trasplantes en el siglo XXI" por un importante grupo de prestigiosos autores nacionales en este campo.
Autores: Azanza, José Ramón; Gómez-Guiu, María de la Almudena; et al.
Libro:  Prescripción y seguimiento terapéutico en Diabetes tipo 2
2011  págs. 7-50
Autores: Azanza, José Ramón;
Libro:  Resumen Científico ICAAC 2010
2011  págs. 151 - 156
Autores: García, Emilio; Azanza, José Ramón;
Libro:  Tratado de Medicina Farmacéutica
2010  págs. 629 - 648
Autores: Azanza, José Ramón; García, Emilio;
Título: Antivíricos
Libro:  Farmacología en Enfermería
2010  págs. 463 - 474
Autores: Azanza, José Ramón; García, Emilio;
Título: Antifúngicos
Libro:  Farmacología en Enfermería
2010  págs. 453 - 462
Autores: García, Emilio; Azanza, José Ramón;
Libro:  Resumen científico ICAAC 2009
2010  págs. 161 - 165
Autores: Azanza, José Ramón; Carcelero E; Codina C; et al.
Libro:  Guía de terapéutica antimicrobiana 2010
2010  págs. 199-201
Autores: Azanza, José Ramón;
Autores: Azanza, José Ramón; Pla-Vidal, Jorge; Sadaba, María Belén; et al.
Autores: Azanza, José Ramón; Pla-Vidal, Jorge; Sadaba, María Belén; et al.
Autores: Azanza, José Ramón; Pla-Vidal, Jorge; Sadaba, María Belén; et al.
Autores: Aldaz Ariz, M.I.; Azanza, José Ramón; et al.
Autores: Azanza, José Ramón; Pla-Vidal, Jorge; Sadaba, María Belén; et al.
Autores: García, Emilio; Azanza, José Ramón; et al.