Nuestros investigadores

Valentín Alzina de Aguilar

Departamento
Pediatría
Clínica Universidad de Navarra. Clínica Universidad de Navarra
Pediatría
Facultad de Medicina. Universidad de Navarra

Publicaciones científicas más recientes (desde 2010)

Autores: Moreno Galarraga, Laura (Autor de correspondencia); Urretavizcaya-Martinez, M. ; Echauri, J. A. ; et al.
Revista: WORLD JOURNAL OF PEDIATRICS
ISSN 1708-8569  Vol. 16  Nº 6  2020  págs. 614 - 622
Background Coronavirus disease 2019 in children, or pediatric COVID-19, initially was described as an acute respiratory syndrome similar to the adult presentation but with less severe manifestations. Methods We describe the clinical characteristics, disease presentation, treatments and outcomes of all pediatric cases with COVID-19 admitted to the reference hospitals in Navarra, Spain during the first wave of the COVID-19 outbreak (February-May 2020). Results We found a low number of hospitalized cases in infants and children compared to adults with a hospitalization ratio of 1:180. Most of these hospitalized cases did not suffer from severe disease. Over 80% of infections reported household contacts, and the mother was the known-contact in 83% of these cases. 72% of hospitalized cases were previously healthy children. We describe how symptoms in pediatric cases are nonspecific and how COVID-19 can be presented with a wide range and variety of symptoms. Respiratory symptoms are not always present, and severe neurological and cardiac features can occur in previously healthy children. Conclusion Epidemiological description and case reports will be key to a better recognition and to adequate treatment of pediatric patients with COVID-19.
Autores: Azcona San Julián, María Cristina; Ochotorena Elicegui, Amaia; Prados Ruiz de Almiron, Mónica; et al.
Revista: HORMONE RESEARCH IN PAEDIATRICS
ISSN 1663-2818  Vol. 90  Nº Supl.1  2018  págs. 586
Autores: Ochotorena Elicegui, Amaia; Prados Ruiz de Almiron, Mónica; Oliver Olid, Asier; et al.
Revista: ENDOCRINOLOGÍA PEDIÁTRICA
ISSN 2013-7788  Vol. 9  Nº Supl. 1  2018  págs. 208
Autores: Suárez Rodríguez, Marta; Azcona San Julián, María Cristina; Alzina de Aguilar, Valentín
Revista: ENDOCRINOLOGIA Y NUTRICION
ISSN 1575-0922  Vol. 60  Nº 7  2013  págs. 352 - 357
Introduction: Recent studies in Spain have shown an inadequate iodine intake in a significant proportion of pregnant women. Pregnancy increases thyroid hormone requirements, and adequate iodine intake is therefore needed. Material and Methods: One hundred and forty-seven women in their third trimester (week 37) of pregnancy provided a blood sample and a 24-hour urine sample to test serum and urine iodine levels and completed a food frequency questionnaire to assess iodine intake during pregnancy. Serum TSH levels were measured in the babies born to the 140 mothers in the postpartum group. Results: Only 10.9% of pregnant women consumed more than 250 ¿g iodine daily, and 24.4% of them consumed less than 100 ¿g daily. Mean free T4 levels were 9.37 pmol/L, and 74 women (54.41%) had levels below the hypothyroxinemia threshold. TSH levels were normal in 135 newborns (96.4%), while 5 (3.6%) had levels higher than 5 ¿U/mL.
Autores: Suárez Rodríguez, Marta; Azcona San Julián, María Cristina; Alzina de Aguilar, Valentín
Revista: ENDOCRINOLOGIA Y NUTRICION
ISSN 1575-0922  Vol. 60  Nº 7  2013  págs. 352 - 357
Introduction: Recent studies in Spain have shown an inadequate iodine intake in a significant proportion of pregnant women. Pregnancy increases thyroid hormone requirements, and adequate iodine intake is therefore needed. Material and methods: One hundred and forty-seven women in their third trimester (week 37) of pregnancy provided a blood sample and a 24-hour urine sample to test serum and urine iodine levels and completed a food frequency questionnaire to assess iodine intake during pregnancy. Serum TSH levels were measured in the babies born to the 140 mothers in the postpartum group. Results: Only 10.9% of pregnant women consumed more than 250 ¿g iodine daily, and 24.4% of them consumed less than 100 ¿g daily. Mean free T4 levels were 9.37 pmol/L, and 74 women (54.41%) had levels below the hypothyroxinemia threshold. TSH levels were normal in 135 newborns (96.4%), while 5 (3.6%) had levels higher than 5 ¿U/mL.
Autores: Suárez Rodríguez, Marta; Azcona San Julián, María Cristina; Alzina de Aguilar, Valentín
Revista: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN 0736-5748  Vol. 30  Nº 6  2012  págs. 435 - 438
Context Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. Objective The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring. Materials and methods The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities. Results 54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.
Autores: Herranz Barbero, Ana; Gómez Martínez de Lecea, Cristina; Tamura Ezcurra, Maria Akiko; et al.
Revista: ANALES DEL SISTEMA SANITARIO DE NAVARRA
ISSN 1137-6627  Vol. 35  Nº 2  2012  págs. 209 - 212
Autores: Trinidad-Ramos, G.; Alzina de Aguilar, Valentín; Jaudenes-Casaubón, C.; et al.
Revista: ACTA OTORRINOLARINGOLOGICA ESPAÑOLA
ISSN 0001-6519  Vol. 61  Nº 1  2010  págs. 69 - 77
Actualmente, el cribado auditivo neonatal se lleva a cabo de forma rutinaria en muchos de los sistemas de salud autonómicos en España. A pesar de la importante expansión del cribado de la hipoacusia desde 2000, su viabilidad y los beneficios de la identificación e intervención tempranas, aún existen importantes retos. En este artículo, la CODEPEH actualiza las recomendaciones que se consideran importantes para el futuro desarrollo de los sistemas de detección e intervención precoz en los siguientes puntos: 1. Protocolos de cribado: se recomienda seguir distintos protocolos para los niños ingresados en cuidados intensivos neonatales y los procedentes de maternidad. 2. Evaluación audiológica: se precisa contar con profesionales con experiencia en evaluación de recién nacidos y niños pequeños para completar tanto el diagnóstico como para la selección y adaptación de audioprótesis. 3. Evaluación médica: los factores de riesgo para la hipoacusia neonatal y adquirida se recogen en una única lista en lugar de estar agrupados por el momento de su aparición. Un protocolo de diagnóstico paso a paso es más eficiente y de coste efectivo que efectuar todas las pruebas simultáneamente. 4. Intervención temprana y seguimiento: todos los profesionales que atienden a niños con hipoacusia deberían contar con un entrenamiento especializado y experiencia en la audición, el habla y el lenguaje. Debe realizarse un control periódico del desarrollo de las habilidades auditivas, si existen sospechas paternas y del estado del oído medio. 5. Control de calidad: la gestión de la información como parte integral del sistema es importante para monitorizar y mejorar la calidad del servicio.
Autores: Alzina de Aguilar, Valentín; Doménech Martínez, E.; Álvarez Zallo, Noelia
Libro:  Sordera Infantil. Del diagnóstico precoz a la inclusión educativa. Guía práctica para el abordaje interdisciplinar
2012  págs. 27 - 50
Autores: Narbona García, Juan; Alzina de Aguilar, Valentín
Libro:  Neurología para Pediatras: Enfoque y manejo práctico
2011  págs. 175-188

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