Nuestros investigadores

José Manuel Giménez Amaya

Publicaciones científicas más recientes (desde 2010)

Autores: Giménez, José Manuel;
ISSN 2300-7648  Vol. 4  Nº 2  2016  págs. 41 - 55
This contribution is aimed to emphasise the author's personal contact with Professor Mariano Artigas and, especially, with the Research Group in Science, Reason and Faith (CRYF, in Spanish) which he founded in 2003 at the University of Navarre. In addition, some reflections about the importance of this Research Group in the context of the development of the university studies are pointed out.
Autores: Bernácer, J; Giménez, José Manuel;
Revista: PLOS ONE
ISSN 1932-6203  Vol. 7  Nº 1  2012 
ICSBackground: The afferent projections of the striatum (caudate nucleus and putamen) are segregated in three territories: associative, sensorimotor and limbic. Striatal interneurons are in part responsible for the integration of these different types of information. Among them, GABAergic interneurons are the most abundant, and can be sorted in three populations according to their content in the calcium binding proteins calretinin (CR), parvalbumin (PV) and calbindin (CB). Conversely, striatal dopaminergic cells (whose role as interneurons is still unclear) are scarce. This study aims to analyze the interneuron distribution in the striatal functional territories, as well as their organization regarding to the striosomal compartment. Methodology/Principal Findings: We used immunohistochemical methods to visualize CR, PV, CB and tyrosine hydroxylase (TH) positive striatal neurons. The interneuronal distribution was assessed by stereological methods applied to every striatal functional territory. Considering the four cell groups altogether, their density was higher in the associative (2120 +/- 91 cells/mm(3)) than in the sensorimotor (959 +/- 47 cells/mm(3)) or limbic (633 +/- 119 cells/mm(3)) territories. CB- and TH-immunoreactive (-ir) cells were distributed rather homogeneously in the three striatal territories. However, the density of CR and PV interneurons were more abundant in the associative and sensorimotor striatum, respectively. Regarding to their compartmental organiz
Autores: de Castro, María Pilar; Mechelli, A; Soutullo, César Alejandro; et al.
ISSN 0925-4927  Vol. 191  Nº 3  2011  págs. 166-173
Both schizophrenia and bipolar disorder have been associated with progressive changes in grey matter (GM) volume. However, the temporal trajectories of these changes are poorly understood. The aim of this study was to assess longitudinal changes in grey matter volume subsequent to the first episode of schizophrenia and of affective psychoses. Adolescent patients with a first episode psychosis (n=26) were scanned twice using magnetic resonance imaging, at first presentation and after a 3-year follow-up period. An age-matched group of healthy volunteers (n=17) was scanned at the same time points. Within-group and between-group changes in regional grey matter volume were examined using voxel-based morphometry. There were significant group by time interactions (p(FDRcorr)<0.05) in the frontal, temporal, parietal, cerebellar cortex, and in the thalamus, mainly reflecting longitudinal reductions in the controls but not in the patients. Subdivision of the patient group revealed that there were similar longitudinal reductions in patients with affective psychoses as in the controls but no volumetric changes in patients with schizophrenia. Psychosis with onset in adolescence or early adulthood may be associated with a delay or a loss of longitudinal reductions in regional grey matter volume that normally occur at this stage of development. These changes may be specific to schizophrenia.
Autores: de Castro, María Pilar; Mechelli, A; Soutullo, César Alejandro; et al.
ISSN 1398-5647  Vol. 13  Nº 5-6  2011  págs. 545-555
Volumetric brain abnormalities are evident in young adults presenting with a first episode of both affective psychoses and schizophrenia, but there are also significant differences between these two patient groups. Clinical outcome after the first episode may be related to the severity of volumetric abnormalities at presentation.
Autores: Bernácer, J; Giménez, José Manuel;
Libro:  Is science compatible with free will?
2012  págs. 177 - 193
The notion of habit learning in Neuroscience implies the automation of 5 an action, which thus discharges consciousness from the supervision of its perfor- 6 mance and eventually restricts flexibility. It has also been assumed that habit 7 learning is against free will, as it has been suggested for pathological conditions 8 such as obsessive-compulsive disorder. This point of view, which might be contro- 9 versial with other notions of habituation, could be an interesting context to analyze 10 at what extent human actions emerge from free will and are consciously carried out. 11 The well-known experiments performed by Benjamin Libet and replicated by 12 others have led some scientists to deny the concept of free will in the human 13 being. However, we think that these experiments posit further questions that should 14 be tackled from a broader point of view. For example: does the readiness potential 15 univocally point to the initiation of any kind of action? Can it be also found in non- 16 deterministic novel actions? Is it causally related to the action, or is it just a ¿mental 17 rehearsal¿ of the action to come? In this contribution, we will try to make a note on 18 these topics in order to explain the neuroscientific concept of habit learning and to 19 relate it to free will in a broader and more philosophical interdisciplinary framework.