Detalle Publicación

Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity

Autores: Ruberte Sánchez, Ana Carolina; Aydillo Miguel, Carlos; Sharma, A. K.; Sanmartín Grijalba, Carmen (Autor de correspondencia); Plano Amatriain, Daniel
Título de la revista: RSC ADVANCES
ISSN: 2046-2069
Volumen: 10
Número: 63
Páginas: 38404 - 38408
Fecha de publicación: 2020
Resumen:
An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.
DOI: https://doi.org/10.1039/d0ra07332f
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