Detalle Publicación

Interleukin-12 Message in a Bottle

Autores: Cirella, A.; Berraondo López, Pedro; Di Trani, C. A .; Melero Bermejo, Ignacio (Autor de correspondencia)
Título de la revista: CLINICAL CANCER RESEARCH
ISSN: 1078-0432
Volumen: 26
Número: 23
Páginas: 6080 - 6082
Fecha de publicación: 2020
Resumen:
IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-3250
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