Detalle Publicación

4-1BB (CD137) in anticancer chimeras

Autores: Melero Bermejo, Ignacio (Autor de correspondencia); Berraondo López, Pedro
Título de la revista: JOURNAL OF EXPERIMENTAL MEDICINE
ISSN: 0022-1007
Volumen: 217
Número: 12
Fecha de publicación: 2020
Resumen:
4-1BB (CD137, TNFRSF9) mediates costimulatory signals important for activation and persistence of cytotoxic T lymphocytes. In this issue of JEM, Oda et al. (https://doi.org/10.1084/jem.20191166) report on a chimeric construction encompassing extracellular Fas and intracellular 4-1BB to dramatically improve adoptive T cell therapy.
DOI: https://doi.org/10.1084/jem.20201562
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