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Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: preliminary experience from a series of 10 Spanish patients

Autores: Recalde Zamacona, Borja; García Tobar, Laura; Argueta Morales, Allan; Alvarez Gigli, Laura; De Andrea, Carlos Eduardo; Fernández Alonso, Mirian; Ezponda Casajús, Ana; Carmona de la Torre, Francisco de Asís; Jordán Iborra, Carlota; Quiroga Vila, Jorge; del Pozo León, José Luis; Zulueta Frances, Javier Joseph; Echarri González, Gemma; Landecho Acha, Manuel Fortún; Lozano Escario, María Dolores
Título de la revista: THORAX
ISSN: 0040-6376
Volumen: 75
Número: 12
Páginas: 1116 - 1118
Fecha de publicación: 2020
Resumen:
In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings in patients infected with the new SARS-CoV2. Lung histopathology shows features of acute and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has been found in line with the cytokine storm theory. Medium-size vessel thrombi were frequent, but capillary thrombi were not present. Despite the elevation of biochemical markers of cardiac injury, little histopathological damage could be confirmed. Viral RNA from paraffin sections was detected at least in one organ in 90% patients.
DOI: https://doi.org/10.1136/thoraxjnl-2020-215577
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