The Human Brain Project is a European brain research initiative for the advancement of neuroscience and to develop technology inspired by brain information. It is possible that the superior functions of the person are explained neurobiologically, although the relevant question still stands. Am I the one who activates your brain or is it the brain that activates me? An integral understanding of the brain requires a deep vision of this structure and its organization that goes from the genetic study to the whole organ and can not be directed only to a single level. Many authors have highlighted different ideas about brain functioning. Despite this important effort, the question arises whether current neuroscience has the optimal tools to explain in detail the functioning of the human brain. To do this, a series of aspects that are integrated into the so-called mental processes are analyzed. Currently, neuroscience does not give a reason for how our brain works globally. Necessary interdisciplinary work will be essential.