Detalle Publicación

Trehalose-based siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

Autores: Carbajo-Gordillo, A. I.; Rodriguez-Lavado, J.; Jiménez-Blanco, J. L.; Benito, J. M.; Di Giorgio, C.; Vélaz Rivas, Itziar; Tros de Ilarduya Apaolaza, María de la Concepción; Mellet, C. O.; Garcia-Fernandez, J. M. (Autor de correspondencia)
Título de la revista: CHEMICAL COMMUNICATIONS
ISSN: 1359-7345
Volumen: 55
Páginas: 8227 - 8230
Fecha de publicación: 2019
Resumen:
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared fromthe disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.
Enlace DADUN: http://hdl.handle.net/10171/58669
DOI: https://doi.org/10.1039/c9cc04489b
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