Detalle Publicación

EDITORIAL

A "Counter-Enhancer'' in Tumor Suppression

Autores: Marchese, Francesco Paolo; Huarte Martínez, Maite (Autor de correspondencia)
Título de la revista: CELL
ISSN: 0092-8674
Volumen: 173
Número: 6
Páginas: 1318 - 1319
Fecha de publicación: 2018
Resumen:
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.'
DOI: https://doi.org/10.1016/j.cell.2018.05.023
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