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Trehalose-based Janus cyclooligosaccharides: the "Click" synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles

Autores: Jiménez-Blanco, J. L.; Ortega-Caballero, F.; Blanco Fernández, Laura; Carmona, T.; Marcelo, G.; Martínez-Negro, M.; Aicart, E.; Junquera, E.; Mendicuti, F.; Tros de Ilarduya Apaolaza, María de la Concepción; Ortiz Mellet, C.; García Fernández, J. M.
Título de la revista: CHEMICAL COMMUNICATIONS
ISSN: 1359-7345
Volumen: 52
Número: 66
Páginas: 10117 - 10120
Fecha de publicación: 2016
Resumen:
The convergent preparation of Janus molecular nanoparticles by thiourea-"clicking" of ¿,¿'-trehalose halves has been implemented; the strategy allows access to macrocyclic derivatives with seggregated cationic and lipophilic domains that in the presence of DNA undergo pH-dependent self-assembly into lamellar superstructures, as established by electrochemical, structural (SAXS), microscopical (TEM) and computational techniques, that mediate transfection in vitro and in vivo.
DOI: https://doi.org/10.1039/c6cc04791b
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