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Increased obesity-associated circulating levels of the extracellular matrix proteins osteopontin, chitinase-3 like-1 and tenascin C are associated with colon cancer

Autores: Catalán Goñi, Victoria; Gómez Ambrosi, Javier; Rodríguez Murueta-Goyena, Amaia; Ramírez Sola, Beatriz; Izaguirre Ascargorta, Maitane; Hernández Lizoáin, José Luis; Baixauli Fons, Jorge; Martí Cruchaga, Pablo; Valentí Azcarate, Víctor; Moncada Durruti, Rafael; Silva Frojan, Camilo; Salvador Rodríguez, Javier; Fruhbeck Martínez, Gema
Título de la revista: PLOS ONE
ISSN: 1932-6203
Volumen: 11
Número: 9
Páginas: e0162189
Fecha de publicación: 2016
Resumen:
To our knowledge, we herein show for the first time that obese patients with CC exhibit increased circulating levels of OPN, YKL-40 and TNC providing further evidence for the influence of obesity on CC development via ECM proteins, representing promising diagnostic biomarkers or target molecules for therapeutics.
DOI: https://doi.org/10.1371/journal.pone.0162189
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