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Impact of isolated hepatitis C virus (HCV) core-specific antibody detection and viral RNA amplification among HCV-seronegative dialysis patients at risk for infection.

Autores: Barril, Guillermina; Quiroga, Juan; Arenas, Maria Dolores; Espinosa, Mario ; García Fernández, Nuria; Cigarrán S; Herrero JA; del Peso G; Caro P; García-Agudo R; Amézquita Y; Blanco A; Martínez-Rubio P; Alcázar JM; González-Parra E; Martín-Gómez A; Castillo I; Bartolomé J; Carreño V (Autor de correspondencia)
Título de la revista: JOURNAL OF CLINICAL MICROBIOLOGY
ISSN: 0095-1137
Volumen: 52
Número: 8
Páginas: 3053-56
Fecha de publicación: 2014
Resumen:
Amplification of hepatitis C virus (HCV) RNA from blood detected occult HCV infections in 30.9% of 210 HCV-seronegative dialysis patients with abnormal liver enzyme levels that had evaded standard HCV testing practices. Isolated HCV core-specific antibody detection identified three additional anti-HCV screening-negative patients lacking HCV RNA amplification in blood who were considered potentially infectious. Together, these findings may affect management of the dialysis setting.
DOI: https://doi.org/10.1128/JCM.01339-14
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