Detalle Publicación

ARTÍCULO

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

Autores: Gallego-Escuredo J; Gómez Ambrosi, Javier; Catalán Goñi, Victoria; Domingo P; Giralt M; Fruhbeck Martínez, Gema; Villarroya, F
Título de la revista: INTERNATIONAL JOURNAL OF OBESITY
ISSN: 0307-0565
Volumen: 39
Número: 1
Páginas: 121-9
Fecha de publicación: 2015
Resumen:
Obesity is characterized by reciprocal alterations in FGF19 (decrease) and FGF21 (increase) levels. Although worsened in diabetic obese patients, obesity itself appears as the predominant determinant of the abnormalities in FGF21 and FGF19 levels. Opposite changes in ß-Klotho expression in fat and liver indicate potential tissue-specific alterations in the responsiveness to endocrine FGFs in obesity
DOI: https://doi.org/ 10.1038/ijo.2014.76
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