Detalle Publicación

Alarmin High-Mobility Group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in ß-cells

Autores: Guzman-Ruiz, Rocío; Ortega, Francisco; Rodríguez Murueta-Goyena, Amaia; Vázquez-Martínez, Rafael; Díaz-Ruiz, Alberto; García-Navarro, Socorro; Giralt, Marta; García-Ríos, Antonio; Cobo-Padilla, Diego; Tinahones, Francisco José; López-Miranda, José; Villarroya, Francesc; Fruhbeck Martínez, Gema; Fernández-Real, José Manuel; Malagón, María del Mar
Título de la revista: INTERNATIONAL JOURNAL OF OBESITY
ISSN: 0307-0565
Volumen: 38
Número: 12
Páginas: 1545-54
Fecha de publicación: 2014
Resumen:
These findings show, for the first time, that HMGB1 expression and release by human adipocytes is altered by inflammatory conditions as those imposed by obesity and insulin resistance. Our data reveal a novel role for HMGB1 as a stimulatory factor of insulin secretion of ß-pancreatic cells.
DOI: https://doi.org/10.1038/IJO.2014.36
Impacto:
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