Nuestros investigadores

Gorka Bastarrika Alemáñ


Publicaciones científicas más recientes (desde 2010)

Autores: Alcaide Ocaña, Ana Belén; Sánchez Salcedo, Pablo Antonio; Bastarrika Alemáñ, Gorka; et al.
Revista: CHEST
ISSN 0012-3692  Vol. 151  Nº 2  2017  págs. 358 - 365
BACKGROUND: The clinical characteristics of patients with emphysema but without airway limitations remain unknown. The goal of this study was to compare the clinical features of current and former smokers without airflow limitation who have radiologic emphysema on chest CT scans vs a control group of current and ex-smokers without emphysema. METHODS: Subjects enrolled had anthropometric characteristics recorded, provided a medical history, and underwent low-dose chest CT scanning. The following parameters were also evaluated: pulmonary function tests including diffusion capacity for carbon monoxide (D-LCO), the modified Medical Research Council dyspnea score, COPD assessment test (CAT), and 6-min walk test (6MWT). Acomparison was conducted between those with and withoutCT-confirmedemphysema. RESULTS: Of the 203 subjects, 154 had emphysema, and 49 did not. Adjusted group comparisons revealed that a higher proportion of patients with emphysema according to low-dose chest CT scanning had an abnormal DLCO value (< 80%) (46% vs 19%; P = .02), a decrease in percentage of oxygen saturation > 4% during the 6MWT (8.5% vs 0; P = .04), and an altered quality of life (CAT score >= 10) (32% vs 14%; P = .01). A detailed analysis of the CAT questionnaire items revealed that more patients with emphysema had a score >= 1 in the "chest tightness" (P = .05) and "limitation when doing activities at home" (P < .01) items compared with those with no emphysema. They also experienced significantly more exacerbations in the previous year (0.19 vs 0.04; P = .02). CONCLUSIONS: A significant proportion of smokers with emphysema according to low-dose chest CT scanning but without airway limitation had alterations in their quality of life, number of exacerbations, DLCO values, and oxygen saturation during the 6MWT test.
Autores: Caballeros Lam, Fanny Meylin; Bartolomé Leal, Pablo; Gonzalez, O. F., ; et al.
ISSN 0284-1851  Vol. 58  Nº 7  2017  págs. 809 - 815
Background: Diffuse myocardial fibrosis can be quantified by calculating extra-cellular volume (ECV) from native and post-contrast T1 values using dedicated single bolus contrast medium injection protocols. Purpose: To evaluate differences in T1 maps and myocardial ECV measurements in routine stress/rest perfusion cardiovascular magnetic resonance (CMR) examinations after injection of single and double dose of contrast medium. Material and Methods: Thirty-seven consecutive patients (30 men; mean age, 62 +/- 13 years) underwent clinically indicated adenosine stress/rest perfusion CMR examination to rule out myocardial ischemia following a conventional split-dose contrast medium injection strategy. Native and post-contrast T1 mapping was performed 15 min after the first (0.1 mmol/kg) and second (0.1 mmol/kg) dose of contrast medium using a breath-held Modified Look-Locker Inversion recovery (MOLLI) sequence. Student's t-test for paired samples, Bland-Altman plots, and concordance-correlation coefficients (CCC) for agreement between T1 and ECV calculations after single and double dose of contrast medium were calculated. Intra- and inter-observer agreement for measurements was also analyzed. Results: Myocardial T1 values after single and double dose of contrast medium significantly differed (mean difference of 114.1 +/- 19.9 ms, P< 0.01). A single dose of contrast agent provided slightly higher ECV values (mean difference of 2.3 +/- 1.1%). CCC for ECV calculations was 0.66. Intra- and inter-observer agreement for all measurements was excellent (CCC >= 0.83). Conclusion: Quantification of myocardial ECV on conventional stress/rest perfusion CMR examination is feasible. T1 maps obtained 15 min after 0.1 mmol/kg of contrast medium provide slightly higher myocardial T1 measurements and ECV values compared with T1 maps obtained after a total dose of 0.2 mmol/kg.
Autores: González Gutiérrez, Jéssica; Henschke, C. , ; Yankelevitz, D. , ; et al.
ISSN 1073-449X  Vol. 195  2017  págs. A7682
Autores: Eiros Bachiller, María del Rocío; González Miqueo, Aránzazu; Pueyo Villoslada, Jesús Ciro; et al.
ISSN 1388-9842  Vol. 19  Nº Supl. 1  2017  págs. 123
Autores: De Torres Tajes, Juan Pablo; Sánchez Salcedo, Pablo Antonio; Bastarrika Alemáñ, Gorka; et al.
ISSN 0903-1936  Vol. 49  Nº 1  2017  págs. 1601521
Autores: García Velloso, María José; Bastarrika Alemáñ, Gorka; De Torres Tajes, Juan Pablo; et al.
ISSN 0169-5002  Vol. 97  2016  págs. 81-86
A major drawback of lung cancer screening programs is the high frequency of false-positive findings on computed tomography (CT). We investigated the accuracy of selective 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) scan in assessing radiologically indeterminate lung nodules detected in lung cancer screening. Methods: FDG PET/CT was performed to characterize 64 baseline lung nodules >10 mm and 36 incidence nodules detected on low-dose CT screening in asymptomatic current or former smokers (83 men, age range 40¿83 years) at high risk for lung cancer. CT images were acquired without intravenous contrast. Nodules were analyzed by size, density, and metabolic activity and visual scored on a 5-point scale for FDG uptake. Nodules were classified as negative for malignancy when no FDG uptake was observed, or positive when focal uptake was observed in the visual analysis, and the maximum standardized uptake value (SUVmax) was measured. Final diagnosis was based on histopathological evaluation or at least 24 months of follow-up. Results: A total of 100 nodules were included. The prevalence of lung cancer was 1%. The sensitivity, specificity, NPV and PPV of visual analysis to detect malignancy were 84%, 95%, 91%, and 91%, respectively, with an accuracy of 91% (AUC 0.893). FDG PET/CT accurately detected 31 malignant tumors (diameters 9¿42 mm, SUVmax range 0.6¿14.2) and was falsely negative in 6 patients. With SUVmax threshold
Autores: Madrid Pérez, José Miguel; García Barquín, Paula María; García Bolao, José Ignacio; et al.
ISSN 0033-8338  Vol. 58  Nº 6  2016  págs. 444 - 453
Objective: Radiofrequency ablation is an efficacious alternative in patients with symptomatic atrial fibrillation who do not respond to or are intolerant to at least one class I or class III antiarrhythmic drug. Although radiofrequency ablation is a safe procedure, complications can occur. Depending on the location, these complications can be classified into those that affect the pulmonary veins themselves, cardiac complications, extracardiac intrathoracic complications, remote complications, and those that result from vascular access. The most common complications are hematomas, arteriovenous fistulas, and pseudoaneurysms at the puncture site. Some complications are benign and transient, such as gastroparesis or diaphragmatic elevation, whereas others are potentially fatal, such as cardiac tamponade. Conclusion: Radiologists must be familiar with the complications that can occur secondary to pulmonary vein ablation to ensure early diagnosis and treatment. (C) 2016 SERAM. Published by Elsevier Espana, S.L.U. All rights reserved.
Autores: Rivera Ortega, Pilar; González Gutiérrez, Jéssica; Restituto Aranguíbel, Patricia; et al.
ISSN 1073-449X  Vol. 193  2016  págs. A3554
Autores: Sánchez Salcedo, Pablo Antonio; Wilson, D. O., ; De Torres Tajes, Juan Pablo; et al.
ISSN 1073-449X  Vol. 191  Nº 8  2015  págs. 924 - 931
Rationale: Lung cancer (LC) screening using low-dose chest computed tomography is now recommended in several guidelines using the National Lung Screening Trial (NLST) entry criteria (age, 55-74; ¿30 pack-years; tobacco cessation within the previous 15 yr for former smokers). Concerns exist about their lack of sensitivity. Objectives: To evaluate the performance of NLST criteria in two different LC screening studies from Europe and the United States, and to explore the effect of using emphysema as a complementary criterion. Methods: Participants from the Pamplona International Early Lung Action Detection Program (P-IELCAP; n = 3,061) and the Pittsburgh Lung Screening Study (PLuSS; n = 3,638) were considered. LC cumulative frequencies, incidence densities, and annual detection rates were calculated in three hypothetical cohorts, including subjects whometNLST criteria alone, those withcomputed tomography-detected emphysema, and those who met NLST criteria and/or had emphysema. Measurements and Main Results: Thirty-six percent and 59% of P-IELCAP and PLuSS participants, respectively, met NLST criteria. Among these, higher LC incidence densities and detection rates were observed. However, applying NLST criteria to our original cohorts would miss asmany as 39% of all LC. Annual screening of subjects meeting either NLST criteria or having emphysema detected most cancers (88% and 95% of incident LC of P-IELCAP and PLuSS, respectively) despite reducing the number of screened participants by as much as 52%. Conclusions: LC screening based solely on NLST criteria could miss a significant number of LC cases. Combining NLST criteria and emphysema to select screening candidates results in higher LC detection rates and a lower number of cancers missed.
Autores: Sánchez Salcedo, Pablo Antonio; Berto Botella, Juan Antonio; De Torres Tajes, Juan Pablo; et al.
ISSN 0300-2896  Vol. 51  Nº 4  2015  págs. 169 - 176
The experience in Spain's longest lung cancer screening program is comparable to what has been described in the rest of Europe, and confirms the feasibility and efficacy of lung cancer screening using LDCT.
Autores: Pérez de Ciriza Villacampa, Carmen; Moreno Rodríguez, María; Restituto Aranguíbel, Patricia; et al.
ISSN 0009-9120  Vol. 47  Nº 18  2014  págs. 272-8
This study shows that OPG may potentially be a biomarker for cardiovascular risk/damage in the MS and identifies adipose tissue as a potential source of OPG.
Autores: Zagaceta Guevara, Jorge Luis; Zulueta Francés, Javier; Bastarrika Alemáñ, Gorka; et al.
Revista: PLOS ONE
ISSN 1932-6203  Vol. 8  Nº 6  2013  págs. e65593
Autores: De Torres Tajes, Juan Pablo; Blanco Barrenechea, David; Alcaide Ocaña, Ana Belén; et al.
Revista: PLOS ONE
ISSN 1932-6203  Vol. 8  Nº 4  2013  págs. e60260
Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases
Autores: Rudyanto, Rina Dewi; Bastarrika Alemáñ, Gorka; De Biurrun Baquedano, Gabriel; et al.
ISSN 1361-8423  Vol. 17  Nº 8  2013  págs. 1095-1105
We present and evaluate an automatic and quantitative method for the complex task of characterizing individual nodule volumetric progression in a longitudinal mouse model of lung cancer. Fourteen A/J mice received an intraperitoneal injection of urethane. Respiratory-gated micro-CT images of the lungs were acquired at 8, 22, and 37 weeks after injection. A radiologist identified a total of 196, 585 and 636 nodules, respectively. The three micro-CT image volumes from every animal were then registered and the nodules automatically matched with an average accuracy of 99.5%. All nodules detected at week 8 were tracked all the way to week 37, and volumetrically segmented to measure their growth and doubling rates. 92.5% of all nodules were correctly segmented, ranging from the earliest stage to advanced stage, where nodule segmentation becomes more challenging due to complex anatomy and nodule overlap. Volume segmentation was validated using a foam lung phantom with embedded polyethylene microspheres. We also correlated growth rates with nodule phenotypes based on histology, to conclude that the growth rate of malignant tumors is significantly higher than that of benign lesions. In conclusion, we present a turnkey solution that combines longitudinal imaging with nodule matching and volumetric nodule segmentation resulting in a powerful tool for preclinical research.
Autores: Grochowicz, Lukasz Karol; Lavilla Royo, Francisco Javier; Olavide Goya, Isidro; et al.
ISSN 0890-5096  Vol. 27  Nº 7  2013  págs. 974.e1 - 974.e6
In the last 20 years, endovascular procedures have radically altered the treatment of diseases of the aorta. The objective of endovascular treatment of dissections is to close the entry point to redirect blood flow toward the true lumen, thereby achieving thrombosis of the false lumen. In extensive chronic dissections that have evolved with the formation of a large aneurysm, the dissection is maintained from the end of the endoprosthesis due to multiple orifices, or reentries, that communicate with the lumens. In addition, one of the primary limitations of this technique is when the visceral arteries have disease involvement. In this report we present a case where, despite having treated the entire length of the descending thoracic aorta, the dissection was maintained distally, leading to progression of the diameter of the aneurysm. After reviewing the literature, and to the best of our knowledge, we describe the first case in which renal autotransplant was performed to allow for subsequent exclusion of the aorta at the thoracoabdominal level using a fenestrated endoprosthesis for the celiac trunk and the superior mesenteric artery.
Autores: Herrero Santos, José Ignacio; Bastarrika Alemáñ, Gorka; D'Avola, Delia; et al.
ISSN 1425-9524  Vol. 18  2013  págs. 587 - 592
Background: The prognosis of non-cutaneous malignancies after liver transplantation is dismal, mainly because most cases are diagnosed at advanced stages. In the last decade, studies have shown the potential role of screening for lung cancer with low-radiation dose computed tomography. Material/Methods: Fifty-nine liver transplant recipients with a cumulative dose of smoking greater than 10 pack-years were enrolled in a lung cancer screening program using yearly low-radiation dose computed tomography. Results: Lung cancer was diagnosed in 7 patients (11.8%), 5 of which were in stage Ia at diagnosis. Patients with lung cancer were significantly older (median age 66 vs. 58 years), had a higher cumulative history of smoking, and had emphysema more frequently than patients without cancer. Conclusions: Screening for lung cancer with low-radiation dose computed tomography in liver transplant recipients results in the diagnosis of lung cancer in early stages.
Autores: Reyna Fortes, María del Carmen; Viudez Berral, Antonio; Lozano Escario, María Dolores; et al.
ISSN 1130-0108  Vol. 105  Nº 8  2013  págs. 500 - 501
Autores: Hernández-Estefanía, R.; Praschker, BL; Bastarrika Alemáñ, Gorka; et al.
ISSN 1010-7940  Vol. 41  Nº 1  2012  págs. 134 - 136
Left atrial appendage (LAA) plays a crucial role as a source of atrial thrombus in patients with atrial fibrillation (AF). Thus, the need to close LAA becomes evident in patients with AF who undergo concomitant mitral valve surgery. Unfortunately, it has been reported a high rate of unsuccessful LAA occlusion, regardless of the technique employed. We propose a safe and simple method for LAA occlusion consisting in invagination of the appendage into the left atrium, followed by two sutures (purse string suture around the base of the LAA and a reinforce running suture).
Autores: Arraiza Sarasa, María; Azcárate Agüero, Pedro María; Arias Fernández, Javier; et al.
ISSN 0033-8419  Vol. 54  Nº 5  2012  págs. 432-441
Autores: Wilson, RB; Schoepf, UJ; Lee, YS; et al.
ISSN 0883-5993  Vol. 27  Nº 2  2012  págs. W32 - 34
Autores: Dell'aquila, Angelo María; Mastrobuoni, Stefano; Bastarrika Alemáñ, Gorka; et al.
ISSN 1569-9293  Vol. 14  Nº 4  2012  págs. 457-462
Despite a more physiological morphology of atrial anastomosis in the bicaval technique with respect to standard biatrial anastomosis in orthotopic heart transplantation (OHT), the impact on the long-term outcome is still not clear. In this retrospective study, we sought to investigate the morphology and function of the atria through magnetic resonance imaging (MRI) and transthoracic echocardiography (TIE). Moreover, we aimed to analyse the accuracy of TIE with respect to MRI. Cox regression analysis of 216 consecutive patients receiving OHT between August 1987 and January 2010 identified only recipient age at the time of transplant to be an independent predictor of mortality (P = 0.048, odds ratio = 1.04). After a mean follow-up of 96.6 +/- 77.7 months, 108 patients were alive, of which 35 were found to be eligible for MRI assessment. In this analysis, left and right atrial volumes were found to be significantly larger in the standard group in comparison with the bicaval group (P = 0.001), and no significant difference between the two techniques was observed in left and right atrio-ventricular output. Moreover, a significantly reduced accuracy was observed (CCC < 0.3) when TIE results were compared with MRI assessment in evaluating atrial dimensions. Although left and right atrial volumes are significantly larger in the standard group in comparison with the bicaval group, we concluded that no significant difference in the atrial output and survival between the two techniques could be demonstrated.
Autores: Simón Yarza, María Isabel; Viteri Ramírez, Guillermo; Sáiz Mendiguren, Ramón; et al.
ISSN 0284-1851  Vol. 53  Nº 5  2012  págs. 536-540
Background: Epicardial adipose tissue (EAT) is an important indicator of cardiovascular risk. This parameter is generally assessed on ECG-gated computed tomography (CT) images. Purpose: To evaluate feasibility and reliability of EAT quantification on non-gated thoracic low-radiationdose CT examinations with respect to prospectively ECG-gated cardiac CT acquisition. Material and Methods: Sixty consecutive asymptomatic smokers (47 men; mean age 64 +/- 9.8 years) underwent low-dose CT of the chest and prospectively ECG-gated cardiac CT acquisitions (64-slice dual-source CT). The two examinations were reconstructed with the same range, field of view, slice thickness, and convolution algorithm. Two independent observers blindly quantified EAT volume using commercially available software. Data were compared with paired sample Student t-test, concordance correlation coefficients (CCC), and Bland-Altman plots. Results: No statistically significant difference was observed for EAT volume quantification with low-dose-CT (141.7 +/- 58.3 mL) with respect to ECG-gated CT (142.7 +/- 57.9 mL). Estimation of CCC showed almost perfect concordance between the two techniques for EAT-volume assessment (CCC, 0.99; mean difference, 0.98 +/- 5.1 mL). Inter-observer agreement for EAT volume estimation was CCC: 0.96 for low-dose-CT examinations and 0.95 for ECG-gated CT. Conclusion: Non-gated low-dose CT allows quantifying EAT with almost the same concordance and reliability as using dedicated prospectively ECG-gated cardiac CT acquisition protocols.
Autores: Arraiza Sarasa, María; Azcárate Agüero, Pedro María; De Cecco, C. N., ; et al.
ISSN 0720-048X  Vol. 81  Nº 11  2012  págs. 3282-3288
Objectives: To establish the accuracy and reliability of cardiac dual-source CT (DSCT) and two-dimensional contrast-enhanced echocardiography (CE-Echo) in estimating left ventricular (LV) parameters with respect to cardiac magnetic resonance imaging (CMR) as the reference standard. Methods: Twenty-five consecutive heart transplant recipients (20 male, mean age 62.7 +/- 10.4 years, mean time since transplantation 8.1 +/- 5.9 years) were prospectively recruited. Two blinded readers independently assessed LV ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV) for each patient after manual tracing of the endo-and epicardial contours in DSCT, CE-Echo and CMR cine images. Student's t-test for paired samples for differences, and Bland and Altman plots and Lin's concordance-correlation coefficients (CCC) for agreement were calculated. Results: There was no statistical difference between left ventricular parameters determined by DSCT and CMR. CE-Echo resulted in significant underestimation of left ventricular volumes (mean difference EDV: 15.94 +/- 14.19 ml and 17.1 +/- 17.06 ml, ESV: 8.5 +/- 9.3 and 7.32 +/- 9.14 ml with respect to DSCT and CMR), and overestimation of EF compared with the cross-sectional imaging modalities (3.78 +/- 8.47% and 2.14 +/- 8.35% with respect to DSCT and CMR). Concordance correlation coefficients for LV parameters using DSCT and CMR were higher (CCC >= 0.75) than CCC values observed between CE-Echo and DSCT- or CMR-derived data (CCC >= 0.54 and CCC >= 0.49, respectively). Interobserver agreement was higher for DSCT and CMR values (CCC >= 0.72 and CCC >= 0.87, respectively). Conclusion: In orthotopic heart transplantation cardiac DSCT allows accurate and reliable estimation of LV parameters compared with CMR, whereas CE-Echo seems to be insufficient to obtain precise measurements. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Autores: Takx, RA; Moscariello, A; Schoepf, UJ; et al.
ISSN 0720-048X  Vol. 81  Nº 4  2012  págs. e598 - 604
Autores: Nance, JW; Bastarrika Alemáñ, Gorka; Kang, DK; et al.
ISSN 0363-8715  Vol. 35  Nº 1  2011  págs. 119 - 125
Autores: Kang, DK; Thilo, C; Schoepf, UJ; et al.
ISSN 1936-878X  Vol. 8  Nº 4  2011  págs. 841 - 849
Autores: Thilo, C.; Hanley, M.; Bastarrika Alemáñ, Gorka; et al.
Revista: Cardiology Review
ISSN 1092-6607  Vol. 18  Nº 5  2011  págs. 219 - 229
Autores: Bastarrika Alemáñ, Gorka; Broncano Cabrero, Jordi; Arraiza Sarasa, María; et al.
Revista: European Radiology
ISSN 0938-7994  Vol. 21  Nº 9  2011  págs. 1887 - 1894
Autores: Mastrobuoni, S.; Dell'aquila, A.M., ; Arraiza Sarasa, María; et al.
ISSN 1873-734X  Vol. 40  Nº 1  2011  págs. 62 - 66
Autores: Bastarrika Alemáñ, Gorka; Simón Yarza, María Isabel; Gavira Gómez, Juan José
ISSN 1569-9293  Vol. 12  Nº 3  2011  págs. 490 - 491
We report a case of an unusual congenital triad consisting of absence of coronary sinus, persistent left superior vena cava and scimitar syndrome incidentally found in a CT-scan performed on a female complaining of exertional dyspnea
Autores: Blackmon, KN; Florin, C; Bogoni, L; et al.
Revista: European Radiology
ISSN 0938-7994  Vol. 21  Nº 6  2011  págs. 1214 - 1223
Autores: Nance, JW; Bamberg, F; Schoepf, UJ; et al.
ISSN 0033-8419  Vol. 260  Nº 2  2011  págs. 373 - 380
Autores: Seijo Maceiras, Luis Miguel; Campo Ezquibela, Aránzazu; De Torres Tajes, Juan Pablo; et al.
ISSN 1944-6586  Vol. 18  Nº 1  2011  págs. 7 - 14
Objective: The objective of our study was to investigate whether fluorodeoxyglucose (FDG) positron emission tomography scanning uptake impacts the yield of transbronchial needle aspiration (TBNA). Methods: We carried out a retrospective analysis of data from 140 consecutive patients (178 lymph nodes) undergoing positron emission tomography-computed tomography scanning and subsequent TBNA with rapid onsite cytologic evaluation of the specimen. Patient and lymph node characteristics, including nodal station, size, FDG uptake, number of passes with the needle, sample adequacy, and the final diagnosis were recorded. Results: The diagnostic yield of TBNA was 75%. Themean short axis lymph node diameter was 18.7+/-9 mm and mean maximum standardized uptake value (SUVmax) was 7.7+/-4. The diagnostic yield depended on the lymph node size [odds ratio (OR)=1.07 (1.00-1.14); P=0.04], clinical suspicion of malignancy [OR=5.13 (1.95-13.52); P=0.001], malignant diagnosis [OR=4.91 (1.71-14.09); P=0.003], and FDG uptake [for SUVmax cutoff of 3.0: OR=33.8 (9.2-124); P<0.001]. Only clinical suspicion of cancer [OR=6.2 (2.2-17.2); P=0.001] and FDG uptake [for SUVmax cutoff of 3.0: OR=33.8 (9.2-123.8); P<0.001] remained significant on multivariate analysis. Receiver operating characteristic curves combining 3 key variables (lymph node size, clinical suspicion of malignancy, and SUVmax) showed an area of 0.83 under the curve for a 2.5 SUVmax cutoff and 0.84 for a 3.0 cutoff. Conclusions: FDG uptake is the single most important variable impacting the TBNA yield. TBNA of lymph nodes with an SUVmax less than 3.0 is rarely diagnostic.
Autores: Ceresa, M; Bastarrika Alemáñ, Gorka; De Torres Tajes, Juan Pablo; et al.
Revista: Academic Radiology
ISSN 1076-6332  Vol. 18  Nº 11  2011  págs. 1382-1390
Autores: Artaechevarria Artieda, Xabier; Blanco Barrenechea, David; De Biurrun Baquedano, Gabriel; et al.
Revista: European Radiology
ISSN 0938-7994  Vol. 21  Nº 5  2011  págs. 954-962
Autores: De Torres Tajes, Juan Pablo; Bastarrika Alemáñ, Gorka; Zagaceta Guevara, J.L., ; et al.
Revista: CHEST
ISSN 0012-3692  Vol. 139  Nº 1  2011  págs. 36 - 42
Phenotypic characterization of patients with COPD may have potential prognostic and therapeutic implications. Available information on the relationship between emphysema and the clinical presentation in patients with COPD is limited to advanced stages of the disease. The objective of this study was to describe emphysema presence, severity, and distribution and its impact on clinical presentation of patients with mild to moderate COPD. METHODS: One hundred fifteen patients with COPD underwent clinical and chest CT scan evaluation for the presence, severity, and distribution of emphysema. Patients with and without emphysema and with different forms of emphysema distribution (upper/lower/core/peel) were compared. The impact of emphysema severity and distribution on clinical presentation was determined. RESULTS: Fifty percent of the patients had mild homogeneously distributed emphysema (1.84; 0.76%-4.77%). Upper and core zones had the more severe degree of emphysema. Patients with emphysema were older, more frequently men, and had lower FEV(1)%, higher total lung capacity percentage, and lower diffusing capacity of the lung for carbon monoxide. No differences were found between the clinical or physiologic parameters of the different emphysema distributions. CONCLUSIONS: In patients with mild to moderate COPD, although the presence of emphysema has an impact on physiologic presentation, its severity and distribution seem to have little impact on clinical presentation.
Autores: Kang, DK; Schoepf, UJ; Bastarrika Alemáñ, Gorka; et al.
ISSN 0887-2171  Vol. 31  Nº 4  2010  págs. 276 - 291
Autores: Lee, YS; Bastarrika Alemáñ, Gorka; Schoepf, UJ
ISSN 0883-5993  Vol. 25  Nº 4  2010  págs. 115 - 117
Anomalies of the course of the right coronary artery are relatively rare but are diagnosed with increasing frequency by noninvasive coronary computed tomography angiography. Although most findings of right coronary artery anomalies are inconsequential, there are certain variants that can result in catastrophic complications during surgical or interventional procedures if not recognized. We present a case of intra-atrial course of the right coronary artery noninvasively diagnosed by dual-source computed tomography coronary angiography
Autores: Bastarrika Alemáñ, Gorka; Zudaire Díaz-Tejeiro, Beatriz; Ferreira Caramalho, Mónica; et al.
Revista: Investigative Radiology
ISSN 0020-9996  Vol. 45  Nº 2  2010  págs. 72 - 76
Introduction: To compare left atrial performance with dual-source CT (DSCT) with respect to magnetic resonance imaging (MRI) in orthotopic heart transplant recipients. Methods: Twenty-nine consecutive heart transplant recipients (27 male,mean age 64.1 +/- 13 years; mean time from transplantation 122.8 +/- 69.7 months) referred for exclusion of cardiac allograft vasculopathy underwent cardiac DSCT and MRI. Standard biatrial technique was employed in 13 subjects whereas 16 were transplanted after the bicaval technique. Axial 5-mm slice-thickness DSCT datasets reconstructed in 5% steps of the cardiac cycle and axial 5-mm SSFP-MRI images were analyzed. Two blinded readers manually traced left atrial contours in random order to estimate end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF). Parameters were compared with a paired sample Student t test. Concordance correlation coefficient (CCC) was calculated to determine measurement agreement between techniques and observers. Results: Left atrial volumes were significantly higher with cardiac DSCT (EDV: 170.9 +/- 78.1 mL; ESV: 139.5 +/- 76.6 mL) than with MRI (EDV: 158.2 +/- 72.5 mL; ESV: 124.2 +/- 68.2 mL), whereas left atrial EF was lower with DSCT (EF: 20.8% +/- 7.5% vs. 23.6% +/- 7.7%) (P < 0.05). Measurement agreement between DSCT and MRI was excellent for all parameters (CCC >= 0.82). Individuals operated with the biatrial anastomosis technique presented significantly higher left atrial volumes and lower EF compared with subjects with bicaval anastomosis. Interobserver agreement was excellent for all parameters (CCC >= 0.80). Conclusion: Even if DSCT slightly overestimates left atrial volumes with respect to MRI, results remain clinically valid. Bicaval surgical technique offers improved left atrial performance compared with standard biatrial anastomosis. DSCT may be used as a reliable tool to estimate left atrial parameters in orthotopic heart transplant recipients.
Autores: Bastarrika Alemáñ, Gorka; Schoepf, UJ
ISSN 0883-5993  Vol. 25  Nº 3  2010  págs. 221 - 230
Autores: Artaechevarria Artieda, Xabier; Blanco Barrenechea, David; Pérez-Martín, D; et al.
Revista: European Radiology
ISSN 0938-7994  Vol. 20  Nº 11  2010  págs. 2600 - 2608
Objectives To evaluate the feasibility of using automatic quantitative analysis of breath hold gated micro-CT images to detect and monitor disease in a mouse model of chronic pulmonary inflammation, and to compare image-based measurements with pulmonary function tests and histomorphometry. Material and methods Forty-nine A/J mice were used, divided into control and inflammation groups. Chronic inflammation was induced by silica aspiration. Fourteen animals were imaged at baseline, and 4, 14, and 34 weeks after silica aspiration, using micro-CT synchronized with ventilator-induced breath holds. Lung input impedance was measured as well using forced oscillation techniques. Five additional animals from each group were killed after micro-CT for comparison with histomorphometry. Results At all time points, micro-CT measurements show statistically significant differences between the two groups, while first differences in functional test parameters appear at 14 weeks. Micro-CT measurements correlate well with histomorphometry and discriminate diseased and healthy groups better than functional tests. Conclusion Longitudinal studies using breath hold gated micro-CT are feasible on the silica-induced model of chronic pulmonary inflammation, and automatic measurements from micro-CT images correlate well with histomorphometry, being more sensitive than functional tests to detect lung damage in this model.
Autores: Schutt, DJ; Swindle, MM; Helke, KL; et al.
ISSN 0018-9294  Vol. 57  Nº 3  2010  págs. 746 - 753
Autores: Arnoldi, E.; Henzler, T.; Bastarrika Alemáñ, Gorka; et al.
Revista: Radiologic clinics of North America
ISSN 0033-8389  Vol. 48  Nº 4  2010  págs. 729 - 744
Autores: Levy Praschker, BG; Bastarrika Alemáñ, Gorka; Dell'Aquila, A; et al.
ISSN 1569-9293  Vol. 11  Nº 4  2010  págs. 499 - 500
Autores: Bastarrika Alemáñ, Gorka; Ramos-Duran, L.; Rosenblum, MA; et al.
Revista: Investigative Radiology
ISSN 0020-9996  Vol. 45  Nº 6  2010  págs. 306 - 313
Autores: Bastarrika Alemáñ, Gorka; Kang, DK; Abro, JA; et al.
Revista: Radiologia
ISSN 0033-8338  Vol. 52  Nº 5  2010  págs. 469 - 472
Autores: Caceres, J.; Ferreira Caramalho, Mónica; Broncano Cabrero, Jordi; et al.
Revista: American Journal Roentgenology
ISSN 0361-803X  Vol. 194  Nº 3  2010  págs. 599 - 603
Autores: Henzler, T.; Hanley, M.; Arnoldi, E.; et al.
ISSN 0883-5993  Vol. 25  Nº 3  2010  págs. 213 - 220
Autores: Alonso Burgos, Alberto; García Tutor, Emilio; Bastarrika Alemáñ, Gorka; et al.
ISSN 1748-6815  Vol. 63  Nº 2  2010  págs. 298 - 304
Autores: Bastarrika Alemáñ, Gorka; Ramos-Duran, L.; Schoepf, UJ; et al.
Revista: Journal of Cardiovascular computed tomography
ISSN 1934-5925  Vol. 4  Nº 2  2010  págs. 127 - 135
Autores: Bastarrika Alemáñ, Gorka; Broncano Cabrero, Jordi; Schoepf, UJ; et al.
Revista: Academic Radiology
ISSN 1076-6332  Vol. 17  Nº 6  2010  págs. 727 - 734
Autores: Seijo Maceiras, Luis Miguel; De Torres Tajes, Juan Pablo; Lozano Escario, María Dolores; et al.
Revista: CHEST
ISSN 0012-3692  Vol. 138  Nº 6  2010  págs. 1316 - 1321
Autores: Bastarrika Alemáñ, Gorka; Redondo Bellón, Pedro
ISSN 0361-803X  Vol. 194  2010  págs. W244-W245