Nuestros investigadores

María Cristina Azcona San Julián

Clínica Universidad de Navarra. Clínica Universidad de Navarra
Líneas de investigación
Obesidad, nutrigenómica, epigenética
Índice H
20, (Scopus, 10/05/2017)

Publicaciones científicas más recientes (desde 2010)

Autores: Marti A; Rendo-Urteaga, T.; et al.
ISSN 1399-543X  Vol. 19  Nº 2  2018  págs. 217 - 222
Background: Inflammation related molecules such as tumor necrosis factor-¿ (TNF-¿), interleukin 6 (IL-6), and cardiotrophin-1 (CT-1) are highly expressed in obese individuals and could partly explain some comorbidities associated to obesity. In obese children, lifestyle interventions are able to lower inflammation and reduce cardiovascular risk factors associated with obesity. The aim of the present work was to study changes in inflammation-related molecules serum and peripheral blood mononuclear cells (PBMC) transcript levels after a 10-week lifestyle intervention in obese children and asses their potential association with glucose metabolism. Methods: Twenty-three obese children (mean age 11.5¿years; 48% males) underwent a 10-week lifestyle not controlled intervention trial. Anthropometric and biochemical measurements were analyzed. Transcript analysis for CT-1, IL-6, and TNF-¿ in PBMC were performed by RT-PCR. Serum cytokine levels were also measured at baseline and after 10-weeks. Results: Participants achieved a significant reduction in body adiposity (0.34 decrease in body mass index-standard deviation), total cholesterol, and glucose levels after 10-weeks. A Significant decrease in serum TNF-¿ and C reactive protein (CRP) were observed. CT-1 transcript levels were significantly reduced (P¿=¿.005) after lifestyle intervention, and these changes were significantly correlated with changes in serum CT-1 levels (r¿=¿0.451; P¿=¿.031). In multiple regression analysis baseline CT-1 transcript levels were positively associated with final insulin (R2 = 0.506; P¿=¿.035) and HOMA-IR values (R2 = 0.473; P¿=¿.034). Conclusions: We reported that serum CRP, TNF-¿, as well as PBMC CT-1 transcript levels were reduced after lifestyle intervention in obese children. More studies are needed to clarify the role of inflammation-related molecules in glucose metabolism.
Autores: Morell-Azanza, L.; et al.
ISSN 1399-543X  Vol. 18  Nº 5  2017  págs. 392 - 398
Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P<.001). After the intervention, oxLDL significantly decreased in the HR group. Moreover, a positive correlation between changes in oxLDL and BMI-SDS (r=0.385, P=.015) was found after the weight loss program. Interestingly, multiple-adjusted regression models showed an association between changes in total cholesterol [B: 0.127, 95% confidence interval (CI): 0.06 to 0.20] and LDL-cholesterol (B: 0.173, 95% CI: 0.08 to 0.26) with changes in oxLDL. Conclusions: Higher baseline oxLDL levels were associated with a higher CMS in obese children. After the weight loss program, a decrease in oxLDL levels was found in HR subjects and the oxLDL levels were associated with BMI-SDS and cholesterol levels.
Autores: Aguinaga-Ontoso, I.; Alvarez - Alvarez, I.; et al.
ISSN 0301-0546  Vol. 45  Nº 3  2017  págs. 227 - 233
Background The objective of the study was to examine the relationship between asthma and overweight¿obesity in Spanish children and adolescents and to determine whether this relationship was affected by gender and atopy. Methods The study involves 8607 Spanish children and adolescents from the International Study of Asthma and Allergies in Childhood phase III. Unconditional logistic regression was used to obtain adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for the association between asthma symptoms and overweight¿obesity in the two groups. Afterwards, it was stratified by sex and rhinoconjunctivitis. Results The prevalence of overweight and obesity in 6¿7-year-old children was 18.6% and 5.2% respectively and in 13¿14 year-old teenagers was 11.4% and 1.1% respectively. Only the obese children, not the overweight children, of the 6¿7 year old group had a higher risk of any asthma symptoms (wheezing ever: OR 1.68 [1.15¿2.47], asthma ever: OR 2.29 [1.43¿3.68], current asthma 2.56 [1.54¿4.28], severe asthma 3.18 [1.50¿6.73], exercise-induced asthma 2.71 [1.45¿5.05]). The obese girls had an increased risk of suffering any asthma symptoms (wheezing ever: OR 1.73 [1.05¿2.91], asthma ever: OR 3.12 [1.67¿5.82], current asthma 3.20 [1.65¿6.19], severe asthma 4.83[1.94¿12.04], exercise-induced asthma 3.68 [1.67¿8.08]). The obese children without rhinoconjunctivitis had a higher risk of asthma symptoms. Conclusions Obesity and asthma symptoms were associated in 6¿7 year-old children but not in 13¿14 year-old teenagers. The association was stronger in non-atopic children and obese girls.
Autores: Moleres, A.; Gómez-Martinez, S.; et al.
ISSN 2047-6310  Vol. 12  Nº 3  2017  págs. 257 - 263
BACKGROUND: Shorter telomeres have been associated with elevated risk for age-related diseases. However, little is known about the biomarker role of telomere length (TL) for predicting inflammation and glucose alterations. OBJECTIVE: The objective of this research is to evaluate the association between TL, inflammatory markers and glucose levels after a 2-month weight-loss programme in obese adolescents. METHODS: Telomere length was measured using a quantitative polymerase chain reaction in 66 obese adolescents aged 12-17 years (51% men) from the EVASYON programme. The adolescents were genotyped for the polymorphism -174G/C (rs1800795) in the IL-6gene, and anthropometric and biochemical markers as well as inflammatory cytokines were analysed. RESULTS: Multiple-adjusted models showed that longer telomeres at baseline were associated with a higher reduction in glucose (B¿=¿-4.08, 95% confidence interval: -6.66 to -1.50) and IL-6 (B¿=¿-1.03, 95% confidence interval: -2.01 to -0.05) serum levels after 2¿months of the weight-loss treatment. The -174G/C polymorphism modulated the association between basal TL and changes in IL-6 (P interaction¿=¿0.029). Thus, subjects with the GG¿+¿GC genotype and with longer telomeres showed a higher decrease in IL-6 levels than CC homozygotes. CONCLUSION: Longer telomeres are associated with an improvement in glucose tolerance and inflammation after a weight-loss programme in obese adolescents. Moreover, the -174G/C polymorphism may influence the relationship between TL and IL-6 changes.
Autores: De-Miguel-Etayo, P.; Muro, C.; Santabárbara, J.; et al.
ISSN 0307-0565  Vol. 40  Nº 1  2016  págs. 84 - 87
The aims of this study were to identify the cognitive and behavioral predictors of dropping out and to estimate the attrition rate during different phases of an intervention program to treat overweight and obesity in adolescents. Overweight/obese adolescents (n=156, aged: 13-16 years; 71 male and 85 female subjects) were included in a multicomponent (diet, physical activity and psychological support) family-based group treatment program. At baseline and after 2 months (intensive phase) and 13 months (extensive phase) of follow-up, we measured adolescents' cognitive and behavioral dimensions, together with the parents' perception of their child's behavior. Of the 156 adolescents selected, 112 completed the full program (drop-out rate of 28.2%). The risk of dropping out during the extensive phase increased by 20% for each unit increase in the adolescent's social insecurity score (odds ratio=1.20, 95% confidence interval=1.07-1.34, P=0.002). The adolescents who had a high interoceptive awareness showed a significant decrease of 13.0% in the probability of dropping out (odds ratio=0.87, 95% confidence interval=0.77-0.99, P=0.040). Adolescents' social insecurity was the main predictor of drop-out in a multicomponent family-group-based obesity treatment program. To reduce attrition rates in these programs, the individual's social insecurity level needs to be reduced, whereas the family's awareness of eating-related behavior needs adjustment
Autores: Gómez, Sara; et al.
ISSN 1662-4025  Vol. 9  Nº Supl. 1  2016  págs. 103
Autores: González-Muniesa, P; et al.
ISSN 0007-1145  Vol. 113  Nº 2  2015  págs. 331 - 342
The present study analyses the gene expression profile of peripheral blood mononuclear cells (PBMC) from obese boys. The aims of the present study were to identify baseline differences between low responders (LR) and high responders (HR) after 10 weeks of a moderate energy-restricted dietary intervention, and to compare the gene expression profile between the baseline and the endpoint of the nutritional intervention. Spanish obese boys (age 10-14 years) were advised to follow a 10-week moderate energy-restricted diet. Participants were classified into two groups based on the association between the response to the nutritional intervention and the changes in BMI standard deviation score (BMI-SDS): HR group (n 6), who had a more decreased BMI-SDS; LR group (n 6), who either maintained or had an even increased BMI-SDS. The expression of 28 869 genes was analysed in PBMC from both groups at baseline and after the nutritional intervention, using the Affymetrix Human Gene 1.1 ST 24-Array plate microarray. At baseline, the HR group showed a lower expression of inflammation and immune response-related pathways, which suggests that the LR group could have a more developed pro-inflammatory phenotype. Concomitantly, LEPR and SIRPB1 genes were highly expressed in the LR group, indicating a tendency towards an impaired immune response and leptin resistance. Moreover, the moderate energy-restricted diet was able to down-regulate the inflammatory 'mitogen-activated protein kinase signalling pathway' in the HR group, as well as some inflammatory genes (AREG and TNFAIP3). The present study confirms that changes in the gene expression profile of PBMC in obese boys may help to understand the weight-loss response. However, further research is required to confirm these findings.
Autores: López, María de los Reyes; Azcona, María Cristina;
ISSN 1695-4033  Vol. 82  Nº 3  2015  págs. 131 - 138
Introducción Los cambios en el estilo de vida y la alimentación han conllevado un aumento progresivo de la prevalencia del sobrepeso-obesidad. Esta enfermedad puede conllevar importantes repercusiones físicas y psicosociales que deterioran la calidad de vida relacionada con la salud (CVRS). La adolescencia es una etapa de gran vulnerabilidad por el entorno y muy determinante en el desarrollo de la personalidad del individuo. El objetivo fue evaluar la influencia del estado ponderal en la CVRS de los adolescentes. Población y métodos Estudio transversal de adolescentes de 12 a 16 años. Evaluación de la CVRS mediante los cuestionarios CHIP-Adolescent Edition. Resultados Ochenta y nueve adolescentes, 60,7%, eran normoponderales y el 39,3% tenía sobrepeso-obesidad. Los participantes normoponderales tenían una edad media superior a los participantes con sobrepeso-obesidad, 14,2 frente a 13,6 años, respectivamente. No había otras diferencias entre las características sociodemográficas de ambos grupos. Los adolescentes con sobrepeso-obesidad reflejaron peor CVRS, concretamente refirieron menor resistencia, menor capacidad de actividad física, menor participación familiar y mayor influencia de sus iguales. Asimismo, las chicas reflejaron menor autoestima, satisfacción, resistencia y capacidad de actividad física que los chicos. Por otro lado, a medida que aumentaba la edad de los participantes, referían menor salud y seguridad en el hogar, mayor riesgo individual y mayor influencia de sus iguales. Conclusión El sobrepeso-obesidad repercute negativamente en la CVRS de los adolescentes. Consideramos importante evaluar los aspectos psicosociales desde la perspectiva del paciente para poder ofrecerle una atención personalizada y multidisciplinar.
Autores: Azcona, María Cristina; Catalan, Ana;
ISSN 2469-5769  Vol. 1  Nº 1  2015  págs. 1 - 6
Objective: To assess the effect of metformin on weight, BMI, body fat, and insulin sensitivity in obese children and adolescents. Methodology: The study was prospective, and included 21 patients with obesity (8 male, 13 female) with a mean age of 12.31 (3.87) years. Inclusion criteria were a fat mass percentage (FM%) of over 25% in males and over 30% in females, a BMI of greater than the 95th percentile, and a lack of response to nutritional and lifestyle changes over three months. Informed consent was obtained from children, parents and the treatment was approved by the hospital's Ethics Committee, and the Spanish health ministry. All subjects received treatment with metformin for six months and each month was instructed to follow nutritional and lifestyle changes. The oral glucose tolerance test (OGTT) was done for 95% of the patients. Results: A decrease in weight-SDS (p< 0.001), BMI-SDS (p< 0.001), FM% (p = 0.002), waist/hip ratio (p = 0.141), HOMA (p = 0.198 and plasma glucose level at 120 min. (p = 0.008) was observed after six months of metformin therapy in association with nutritional and lifestyle changes. At the onset of the study, plasma glucose level at 120 min. was above 140 mg/dL in 38% (n = 8) of patients, and the HOMA index was above 3.8 in 42% (n = 9). Altogether, 11 patients had insulin resistance. Mean dose of metformin was built up to a maximum of 1275 mg/day. Twenty-four percent of the subjects complained of dyspepsia or diarrhea or both. Conclusion: In this study, metformin, combined with diet and lifestyle changes, contributed to an improvement in BMI and to a loss of weight and body fat in children with obesity, whether or not that obesity was associated with insulin resistance.
Autores: De-Miguel-Etayo, P.; Moreno, Luis A.; Santabárbara, J.; et al.
ISSN 0212-1611  Vol. 32  Nº 6  2015  págs. 2525 - 2534
Introduction: the main objectives of weight-loss interventions are to decrease fat mass while maintaining fatfree mass. Objective: our aim was to address effectiveness body composition changes in overweight adolescents assessed by different body composition methods following an obesity intervention programme. Material and Methods: the life-style intervention was multi-disciplinary, with 13 months follow-up. Participants were 13-to-16 year-old overweight, or obese, Spanish adolescents. The adolescents (n = 156; 54.8% females) had body composition measured with anthropometry, dual-energy X-ray absorptiometry and air-displacement plethysmography. All measurements were made at baseline, and after 2- and 13-months. Repeated measures analysis of covariance to compare mean anthropometric changes over time and the Bonferroni correction were applied. Imputation of anthropometric measures was performed. Results: a high significant decrease in fat mass index was achieved in males after 2-and 13-months of intervention as measured by anthropometry (1.16 and 1.56 kg / m2, respectively), X-ray absorptiometry (1.51 and 1.91 kg / m2) and plethysmography (2.13 and 2.44 kg/m2). Moreover, a short and long-term maintenance of fat-and fat-free mass index was observed by X-ray absorptiometry in females (0.94 and 0.68 kg/m2). Conclusion: our multidisciplinary approach to lifestyle intervention has a favourable impact on body fat mass and fat-free mass index as well as waist-to-height ratio, over 13 months intervention in overweight and obese adolescents.
Autores: A. Marcos; et al.
Revista: PLOS ONE
ISSN 1932-6203  Vol. 9  Nº 2  2014  págs. e89828
Context: Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents. Objective: To evaluate the association between telomere length (TL) and adiposity markers in overweight/obese adolescents after an intensive program. We hypothesize that greater TL at baseline would predict a better response to a weight loss treatment. Design, Setting, Patients and Intervention: The EVASYON is a multidisciplinary treatment program for adolescents with overweight and obesity that is aimed at applying the intervention to all possibly involved areas of the individual, such as dietary habits, physical activity and cognitive and psychological profiles. Seventy-four participants (36 males, 38 females, 12-16 yr) were enrolled in the intervention program: 2 months of an energy-restricted diet and a follow-up period (6 months). Main Outcome: TL was measured by quantitative real-time polymerase chain reaction at baseline and after 2 months; meanwhile, anthropometric variables were also assessed after 6 months of follow-up. Results: TL lengthened in participants during the intensive period (+1.9±1.0, p<0.001) being greater in overweight/obese adolescents with the shortest telomeres at baseline (r = -0.962, p<0.001). Multivariable linear regression analysis showed that higher baseline TL significantly predicted a higher decrease in body weight (B = -1.53, p = 0.005; B = -2.25, p = 0.047) and in standard deviation score for body mass index (BMI-SDS) (B = -0.22, p = 0.010; B = -0.47, p = 0.005) after the intensive and extensive period treatment respectively, in boys. Conclusion: Our study shows that a weight loss intervention is accompanied by a significant increase in TL in overweight/obese adolescents. Moreover, we suggest that initial longer TL could be a potential predictor for a better weight loss response.
Autores: Álvarez Zallo, N; Guillén, Francisco; Aguinaga-Ontoso, I.; et al.
ISSN 0212-1611  Vol. 30  Nº 3  2014  págs. 519-525
La obesidad en niños esta relacionada con los síntomas de asma. Las niñas obesas presentan un mayor riesgo y mayor gravedad de síntomas de asma que los niños.
Autores: Puchau, María Blanca; Chueca, M.; et al.
ISSN 0340-6199  Vol. 173  Nº 5  2014  págs. 609 - 616
Dietary and serum total antioxidant capacity (TAC) are considered appropriate tools for investigating the potential health effects of dietary antioxidants consumed in mixed diets. The aim was to analyze the impact of a dietary intervention on macronutrient intakes and to evaluate the improvement on oxidative status after weight loss (WL) by measuring dietary and serum TAC, and urinary F2-isoprostane levels as markers of oxidative stress. Forty-four overweight/obese children (mean age 11.5 years) were enrolled to undergo a 10-week WL program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after intervention. Subjects were prescribed with a fixed full-day meal diet, calculated according to their basal metabolic rate and physical activity levels. A validated food-frequency questionnaire was used to retrospectively calculate TAC and daily nutrient intake. The HR subjects were able to reduce anthropometric indices and to improve lipid and glucose profile. They also significantly diminished fat intake (p¿=¿0.013). Moreover, baseline serum TAC values did significantly predict the reduction in urinary F2 isoprostane (B¿=¿-0.236 (-0.393 to -0.078); p¿=¿0.014) in the HR group after the WL program. Notably, changes in dietary TAC after the treatment were associated with a decrease in body weight after the 10-week intervention (B¿=¿-2.815 (-5.313 to -0.318), p¿=¿0.029) in the HR group. The -¿SerumTAC/¿DietaryTAC and the -¿F2Isoprostane/¿DietaryTAC ratios revealed that the relationships between oxidative markers and antioxidants dietary intake were more favorable in the HR than in the LR group. Conclusion: Our study showed that a 10-week WL program was able to reduce adiposity indices in obese children. Moreover, after the intervention changes in dietary TAC and WL were significantly associated. Our result suggests that specific food with a high TAC content (such as fruits, vegetables, and legumes) could be recommended to improve WL.
Autores: Milagro FI; Marcos, A.; et al.
ISSN 0212-1611  Vol. 30  Nº 1  2014  págs. 75 - 83
Background: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. Objective: In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents. Methods: The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme ( Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention. Results: Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to under - stand the weight loss response. Conclusion: Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents.
Autores: Azcona, María Cristina;
ISSN 1696-2818  Vol. 11  Nº 4  2013  págs. 181 - 186
Autores: Azcona, María Cristina; Alzina, Valentín;
ISSN 1575-0922  Vol. 60  Nº 7  2013  págs. 352 - 357
Introduction: Recent studies in Spain have shown an inadequate iodine intake in a significant proportion of pregnant women. Pregnancy increases thyroid hormone requirements, and adequate iodine intake is therefore needed. Material and Methods: One hundred and forty-seven women in their third trimester (week 37) of pregnancy provided a blood sample and a 24-hour urine sample to test serum and urine iodine levels and completed a food frequency questionnaire to assess iodine intake during pregnancy. Serum TSH levels were measured in the babies born to the 140 mothers in the postpartum group. Results: Only 10.9% of pregnant women consumed more than 250 ¿g iodine daily, and 24.4% of them consumed less than 100 ¿g daily. Mean free T4 levels were 9.37 pmol/L, and 74 women (54.41%) had levels below the hypothyroxinemia threshold. TSH levels were normal in 135 newborns (96.4%), while 5 (3.6%) had levels higher than 5 ¿U/mL.
Autores: López, María de los Reyes; Azcona, María Cristina;
ISSN 0325-0075  Vol. 111  Nº 6  2013  págs. 508-515
La concordancia entre padres e hijosen la percepción de la CVRS, según el estado ponderal de los niños, fue media-baja, pero sin diferencias significativas. La percepción de los padres fue significativamente de menor CVRS en los niños con sobrepeso-obesidad.
Autores: Campión, Francisco Javier; Milagro FI; et al.
ISSN 0892-6638  Vol. 27  Nº 6  2013  págs. 2504 - 2512
In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human¿s lifetime. The objective of this work was to explore baseline changes in DNA methylation that could be associated with a better weight loss response after a multidisciplinary intervention program in Spanish obese or overweight adolescents. Overweight or obese adolescents (n=107) undergoing 10 wk of a multidisciplinary intervention for weight loss were assigned as high or low responders to the treatment. A methylation microarray was performed to search for baseline epigenetic differences between the 2 groups (12 subjects/group), and MALDI-TOF mass spectrometry was used to validate (n=107) relevant CpG sites and surrounding regions. After validation, 5 regions located in or near AQP9, DUSP22, HIPK3, TNNT1, and TNNI3 genes showed differential methylation levels between high and low responders to the multidisciplinary weight loss intervention. Moreover, a calculated methylation score was significantly associated with changes in weight, BMI-SDS, and body fat mass loss after the treatment. In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents.
Autores: Chueca M; et al.
ISSN 0026-0495  Vol. 62  Nº 10  2013  págs. 1429 - 1436
OBJECTIVE: Cardiotrophin-1 (CT-1) shares some similarities with other cytokines, and participates in the control of energy metabolism. Higher circulating levels are observed in obese humans, but little information is gathered in weight loss (WL) programs. Therefore, we aimed to investigate the association of serum CT-1 levels with metabolic variables and the risk of developing metabolic syndrome (MetS) after a WL program in overweight/obese children. SUBJECTS AND METHODS: Forty-four overweight/obese children (mean age 11.5y; 50% males) undergoing a 10-week WL program were enrolled. Subjects were dichotomized at the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change, as high and low responders after intervention. RESULTS: CT-1 levels were significantly reduced (-48 fmol/mL, p=0.043) in the high responder group after the WL program. They had significantly lower body weight (-3.7kg, p<0.001), body fat mass (-8%, p<0.001), BMI-SDS (-0.78, p<0.001) and waist circumference (-5.4cm, p<0.001), and a significant improvement in lipid and glucose profiles (p<0.05). Interestingly, decreased CT-1 levels significantly predicted changes in total cholesterol (41%) and LDL-cholesterol (28%). Moreover, in our participants the lower the CT-1 levels, the higher the reduction in MetS risk components, after the 10-week intervention, (p-ANCOVA=0.040, p-trend=0.024). CONCLUSION: We showed, for the first time, a reduction in serum CT-1 levels after a WL program and this decrease in CT-1 was strongly associated with a reduction in cholesterol levels and in MetS risk factors in overweight/obese children. Our findings may suggest that CT-1 could be an indirect marker for the diagnosis of MetS in this population.
Autores: Chueca, M.; et al.
ISSN 1662-4025  Vol. 6  Nº Suppl. 1  2013  págs. 228 - 229
Autores: Campión, Francisco Javier; Milagro FI; et al.
ISSN 0250-6807  Vol. 63  Nº Suppl. 1  2013  págs. 375
Autores: Zulet, María de los Ángeles; et al.
ISSN 0022-3476  Vol. 161  Nº 3  2012  págs. 466-470
OBJECTIVE: To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents. STUDY DESIGN: Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes. RESULTS: At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS. CONCLUSIONS: The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.
Autores:  et al.
Revista: Nutricion Hospitalaria
ISSN 0212-1611  Vol. 27  Nº 1  2012  págs. 165 - 176
The aim of this article is to describe the dietary intervention design and the methods used to evaluate nutritional knowledge and behavior in the EVASYON study (Development, implementation and evaluation of the efficacy of a therapeutic programme for over
Autores: García, Lorena; Azcona, María Cristina;
Revista: Revista Pediatría Atención Primaria
ISSN 1139-7632  Vol. 14  Nº 53  2012  págs. 61 - 67
La síntesis de andrógenos en la mujer se produce en las glándulas suprarrenales, en el ovario y en los tejidos diana periféricos para la acción androgénica (piel, músculo y tejido adiposo). El exceso de producción androgénica (o hiperandrogenismo) en la infancia y adolescencia puede determinar alteraciones en estos tejidos diana, condicionando la aparición de hirsutismo, acné, trastornos menstruales o virilización, cuya intensidad y momento de aparición dependerán del origen del exceso de producción de andrógenos. La etiología del hiperandrogenismo variará según la edad. Así, en el periodo prepuberal, en ausencia de maduración gonadal la hiperproducción androgénica tendrá origen en la glándula suprarrenal en la mayoría de los casos, mientras que en el periodo peripuberal y postpuberal el ovario será el responsable.
Autores: Ochoa, María del Carmen; et al.
ISSN 0007-1145  Vol. 107  Nº 4  2012  págs. 533 - 538
The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been widely associated with childhood obesity in several European cohorts. This association appears to be dependent on dietary macronutrients. Therefore, the aim of the present study was to evaluate whether dietary fatty acid intake distribution could interact with this FTO genetic variation and obesity in a Spanish case-control study of children and adolescents. A total of 354 Spanish children and adolescents aged 6-18 years (49% males) were genotyped for the rs9939609 variant of the FTO gene. Anthropometric parameters were taken and energy intake was measured. We observed an interaction between the consumption of SFA (percentage of total energy) and PUFA: SFA ratio and obesity risk linked to the rs9939609 SNP of the FTO gene. In the study population of the present study, the risk allele carriers consuming more than 12.6% SFA (of total energy) had an increased obesity risk compared with TT carriers. In a similar way, A allele carriers with an intake ratio lower than 0.43 PUFA: SFA presented a higher obesity risk than TT subjects. In summary, the present study reports for the first time the influence of dietary fatty acid distribution on the effect of the rs9939609 polymorphism of the FTO gene on children and adolescents' obesity risk.
Autores: Azcona, María Cristina; Alzina, Valentín;
ISSN 0736-5748  Vol. 30  Nº 6  2012  págs. 435 - 438
Context Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. Objective The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring. Materials and methods The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities. Results 54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.
Autores: Patiño-Garcia, Ana; Azcona, María Cristina;
ISSN 1134-9824  Vol. 15  Nº 1  2012  págs. 46 - 51
Autores: Díez López I; Sarasua Miranda A.; Azcona, María Cristina; et al.
ISSN 1134-9824  Vol. 15  Nº 1  2012  págs. 52 - 57
Autores: Terán, A.; et al.
ISSN 0212-1611  Vol. 27  Nº 5  2012  págs. 28
Autores: Campión, Francisco Javier; Milagro FI; et al.
ISSN 1662-4025  Vol. 5  Nº Suppl. 1  2012  págs. 173
Autores: Chueca, M; et al.
Revista: Annals of Nutrition and Metabolism
ISSN 0250-6807  Vol. 58  Nº Supl. 3  2011  págs. 265 - 266
Autores: Toumba, Meropi; Albanese, Assunta; Azcona, María Cristina; et al.
ISSN 1663-2818  Vol. 74  Nº 3  2010  págs. 212 - 217
Background: The aim of this study was to determine the beneficial effects of long-term growth hormone (GH) treatment on final height (FH) in 26 children with Russell-Silver syndrome (RSS). Methods: Twenty-six patients (16 males) were diagnosed with RSS at a median age of 2.9 years according to clinical criteria. All patients were prepubertal at the commencement of treatment. They received treatment with biosynthetic human GH for 9.8 years (median) and all attained FH. Results: The median height at the commencement of treatment was -2.7 SDS and increased to -1.3 SDS (p = 0.001). However, FH did not reach target height (-0.90 SDS, p = 0.003). Predictors of FH outcome were: the height at the start of treatment (r(2) = 0.419, p &lt; 0.001) (inversely related) and the height gain at onset of puberty (r(2) = 0.257, p &lt; 0.001) (positively related). The overall prediction model accounted for 67.6% of height gain. Sitting height improved gradually during GH treatment (-3.3 to -1.0 SDS, p = 0.012), as did weight (-3.3 to -1.3 SDS, p &lt; 0.001) and BMI (-1.5 to -0.2 SDS, p &lt; 0.001). Conclusions: A significant improvement of growth in RSS children has been shown after 10 years of GH treatment with a FH of -1.3 SDS. The shorter the patient at the start of treatment is, the greater the increment in FH. A significant response is also shown at the onset of puberty. GH treatment may also have a beneficial effect on the spinal length of RSS children.